A5082783833- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- SARS-CoV-2 detection and testing
- Plasmonic and Surface Plasmon Research
- Stellar, planetary, and galactic studies
- Electrochemical sensors and biosensors
- Schizophrenia research and treatment
- Astronomy and Astrophysical Research
- Digital Holography and Microscopy
- Viral gastroenteritis research and epidemiology
- Electrochemical Analysis and Applications
- SARS-CoV-2 and COVID-19 Research
- Fluid Dynamics and Thin Films
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- Neuroscience and Neural Engineering
- Clostridium difficile and Clostridium perfringens research
- Optical Coatings and Gratings
- Astronomical Observations and Instrumentation
- Escherichia coli research studies
- Neurological disorders and treatments
- Cell Image Analysis Techniques
- Microscopic Colitis
- IL-33, ST2, and ILC Pathways
Samsung Medical Center
2016-2025
Sungkyunkwan University
2017-2025
Samsung (South Korea)
2011-2024
Hongik University
2020-2023
Korea University
2023
Maria Fertility Hospital
2023
Texas A&M University
2023
Sogang University
1998-2020
The Ohio State University
2014-2020
Fudan University
2019
Worldwide outbreaks of infectious diseases necessitate the development rapid and accurate diagnostic methods. Colorimetric assays are a representative tool to simply identify target molecules in specimens through color changes an indicator (e.g., nanosized metallic particle, dye molecules). The detection method is used confirm presence biomarkers visually measure absorbance colored compounds at specific wavelength. In this study, we propose colorimetric assay based on extended form...
This work reports a facile wafer-level fabrication for nanogap-rich gold nanoislands highly sensitive surface enhanced Raman scattering (SERS) by repeating solid-state thermal dewetting of thin film. The method provides enlarged with small gap spacing, which increase the number electromagnetic hotspots and thus enhance extinction intensity as well tunability plasmon resonance wavelength. plasmonic from repeated substantially SERS enhancement factor over one order-of-magnitude higher than...
Synergistic integration of the Internet Things (IoT), cloud computing, and big data technologies in healthcare have led to notion "smart health." Smart health is an emerging concept that refers provision services for prevention, diagnosis, treatment, follow-up management at any time or place by connecting information healthcare. As a significant breakthrough smart development, IoT-enabled devices allow medical centers carry out preventive care, treatment more competently. This review focuses...
Advent and fast spread of pandemic diseases draw worldwide attention to rapid, prompt, accurate molecular diagnostics with technical development ultrafast polymerase chain reaction (PCR). Microfluidic on-chip PCR platforms provide highly efficient small-volume bioassay for point-of-care diagnostic applications. Here we report ultrafast, real-time, nanoplasmonic rapid quantitative at level. The plasmofluidic chip comprises glass nanopillar arrays Au nanoislands gas-permeable microfluidic...
A surface-enhanced Raman scattering-based lateral flow assay (SERS-LFA) technique has been developed for the rapid and accurate diagnosis of scrub typhus. Lateral kits detection O. tsutsugamushi IgG (scrub typhus biomarker) were fabricated, calibration curve various standard clinical sera concentrations obtained by measurements. The titer values determined fitting data to curve. To assess feasibility proposed method, SERS-LFA assays performed on 40 samples. results showed good agreement with...
The healthcare industry is in dire need of rapid microbial identification techniques for treating infections. Microbial infections are a major issue worldwide, as these widespread diseases often develop into deadly symptoms. While studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality infection, this effective difficult to practice. main obstacle treatments long turnaround time routine identification, which includes time-consuming sample growth....
Abstract We characterized 8 human hepatocellular‐carcinoma cell lines established from the primary tumors of Korean patients. All showed substrate adherence and one line anaplastic tumor also grew as floating aggregates. Most cultured cells maintained many morphological characteristics original which they were derived. Doubling times varied 34 to 72 hr. relatively high viability not contaminated with Mycoplasma or bacteria. aneuploidy proven be unique by DNA fingerprinting analysis....
Emerging molecular diagnosis requires ultrafast polymerase chain reaction (PCR) on chip for rapid precise detection of infectious diseases in the point-of-care test. Here, we report nanoplasmonic on-chip PCR precision diagnostics. The pillar arrays (NPA) comprise gold nanoislands top and sidewall large-scale glass nanopillar arrays. pillars enhance light absorption a white light-emitting diode (LED) over whole visible range due to strong electromagnetic hotspots between nanoislands. As...
A quantitative correlation between plasmon resonance and surface enhanced Raman scattering (SERS) signals is revealed by using a novel active plasmonic method, that is, deformable nanoplasmonic membrane. single SERS peak has the maximum gain at corresponding wavelength, which extinction product of an excitation wavelengths. As service to our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be re-organized for online...
High-throughput small-molecule assays play essential roles in biomedical diagnosis, drug discovery, environmental analysis, and physiological function research. Nanoplasmonics holds a great potential for the label-free detection of small molecules at extremely low concentrations. Here, we report development nanoplasmonic paper (NP-paper) rapid separation ultrasensitive mixed molecules. NP-paper employs nanogap-rich silver nanoislands on cellulose fibers, which were simply fabricated wafer...
The COVID-19 outbreak has caused public and global health crises. However, the lack of on-site fast, reliable, sensitive, low-cost reverse transcription polymerase chain reaction (RT-PCR) testing limits early detection, timely isolation, epidemic prevention control. Here, authors report a rapid mobile efficient diagnostics infectious diseases via on-chip -RT-quantitative PCR (RT-qPCR): MEDIC-PCR. First, use roll-to-roll printing process to accomplish carbon-black-based disposable chips that...
A 3,4-ethylenedioxythiophene derivative bearing a viologen unit has been synthesized and electropolymerized to form the corresponding polymer (see Figure). Electrochemical spectroelectrochemical studies showed that characteristics of both PEDOT viologen, possesses high electrochromic contrast due cooperative action viologen.
The surface-enhanced Raman scattering enhancement (SERS) of small molecules spatially entrapped near hot spots by using nanofluidic channels with localized surface plasmon resonance is reported. Small are introduced into the interstitial nanogaps between a silver film over nanospheres and polydimethylsiloxane, which serve as 'nanofluidic channels.' concurrence nanofluid stagnation points greatly enhances SERS signals.
The cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPDH, EC 1.2.1.12, GapC) plays an important role in glycolysis by providing the cell with ATP and NADH. Interestingly, despite its glycolytic function cytosol, GAPDH was reported to possess additional non-glycolytic activities, correlating nuclear, or cytoskeletal localization animal cells. In transiently transformed mesophyll protoplasts from Arabidopsis thaliana colocalization interaction of enzymes mitochondria actin cytoskeleton...
The myosin-V family of molecular motors is known to be under sophisticated regulation, but our knowledge the roles and regulation myosin-Vs in cytokinesis limited. Here, we report that Myo51 affects contractile ring assembly stability during fission yeast cytokinesis, regulated by two novel coiled-coil proteins, Rng8 Rng9. Both rng8Δ rng9Δ cells display similar defects as myo51Δ cytokinesis. Rng9 are required for Myo51’s localizations cytoplasmic puncta, actin cables, ring. puncta contain...
Unlike monometallic materials, bimetallic plasmonic materials offer extensive benefits such as broadband tuning capability or high environmental stability. Here we report a broad range of plasmon resonance alloyed nanoislands by using solid-state dewetting gold and silver bilayer thin films. Thermal after successive thermal evaporation metal double-layer films readily forms AuAg-alloyed with precise composition ratio. The complete miscibility results in programmable wavelength visible range....
Several studies have investigated the use of invasive and non-invasive stimulation methods to enhance nerve regeneration, varying degrees effectiveness been reported. However, due different parameters in these studies, a fair comparison between is not possible. The present study compared using similar parameters. Eighteen Sprague Dawley rats were classified into three groups: iES group stimulated with fully implantable device, tES transcutaneous electrical (TENS), injury (no stimulation)....
We construct a multiplex surface-enhanced Raman scattering (SERS) platform based on plasmonic paper substrate and double-labeled probe for the detection of multiple fluorescent dyes at high sensitivity in single-wavelength light source system. Plasmonic paper, made silver nanodots three-dimensional cellulose fibers, enables highly sensitive SERS biosensing localized surface plasmon resonance (LSPR). The proposed method identification quantification range ranging from picomolar to millimolar...
We investigated the neurocognitive deficits in schizophrenic patients with and without obsessive-compulsive disorder (OCD).We grouped 27 as either or non-obsessive-compulsive based on presence of OCD. The two groups completed Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Positive Negative Symptom (PANSS), Hamilton Depression Scale. intelligence quotient (IQ) was tested using Korean Wechsler Adult Intelligence memory (MQ) Korean-Auditory Verbal Learning Korean-Complex Figure Test. executive...