Cuticular nanostructures found in insects effectively manage light for polarization, structural color, or optical index matching within an ultrathin natural scale. These are mainly dedicated to incoming and recently inspired many imaging display applications. A bioluminescent organ, such as a firefly lantern, helps out-couple from the body highly efficient fashion delivering strong signals sexual communication. However, cuticular nanostructures, except light-producing reactions, have not...

Advent and fast spread of pandemic diseases draw worldwide attention to rapid, prompt, accurate molecular diagnostics with technical development ultrafast polymerase chain reaction (PCR). Microfluidic on-chip PCR platforms provide highly efficient small-volume bioassay for point-of-care diagnostic applications. Here we report ultrafast, real-time, nanoplasmonic rapid quantitative at level. The plasmofluidic chip comprises glass nanopillar arrays Au nanoislands gas-permeable microfluidic...

Emerging molecular diagnosis requires ultrafast polymerase chain reaction (PCR) on chip for rapid precise detection of infectious diseases in the point-of-care test. Here, we report nanoplasmonic on-chip PCR precision diagnostics. The pillar arrays (NPA) comprise gold nanoislands top and sidewall large-scale glass nanopillar arrays. pillars enhance light absorption a white light-emitting diode (LED) over whole visible range due to strong electromagnetic hotspots between nanoislands. As...

Abstract Biological wonders, found in insects such as antireflecting moth eyes, compound eyes a honey bee, firefly lanterns, and iridescent butterfly wings, inspire human beings for advanced light imaging illumination technologies. Dazzling advances of micro‐ nanofabrication technologies allow insect‐inspired structures, example, artificial with wide field view low aberration, bioinspired light‐emitting diode lenses, structural coloration templates, featuring miniaturization. Besides,...

Unlike monometallic materials, bimetallic plasmonic materials offer extensive benefits such as broadband tuning capability or high environmental stability. Here we report a broad range of plasmon resonance alloyed nanoislands by using solid-state dewetting gold and silver bilayer thin films. Thermal after successive thermal evaporation metal double-layer films readily forms AuAg-alloyed with precise composition ratio. The complete miscibility results in programmable wavelength visible range....

3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development 3D-PACT requires high-performance acoustic sensors a small size, detection bandwidth, sensitivity. In this work, we present new high-frequency system that uses micro-ring resonator (MRR) as the sensor. MRR sensor size 80 μm diameter, was fabricated using nanoimprint lithography technology. Using...

To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants Korea were screened for their antilipase activity prevention of obesity. Dried and powdered extracted three times with EtOH extracts obtained by removal the solvent in vacuo . Lipase was determined measuring hydrolysis p ‐nitrophenyl butyrate to ‐nitrophenol. Also, inhibitory effect measured on phosphodiesterase (PDE), another therapeutic target Of tested, Sorbus...

To identify effective herb to treat obesity, we screened 115 herbal extracts for inhibition of porcine pancreatic lipase (triacylg-ycerol acylhydrolase, EC 3.1.1.3) activity in vitro. Of the tested, Cudrania tricuspidata leaves exhibited most pronounced inhibitory effect on with an IC(50) value 9.91 μg/mL. Antilipid absorption effects C. were examined rats after oral administration lipid emulsions containing 50 or 250 mg tricuspidata/kg body weight. Plasma triacylglycerol levels 2 h...

Alloyed metals in nanoscale exhibit some intriguing features that are absent mono-metallic nanostructures. Here we report silver and gold alloyed nanoislands with high tunability of localized surface plasmon resonance (LSPR) wavelength the visible range for wafer-level plasmonic color filter arrays. The nanofabrication includes two simple steps concurrent thermal evaporation Ag Au grains solid-state dewetting as-deposited nanocomposite thin film. alloy ratio during precisely tunes LSPR...

Spectroscopic single-molecule localization microscopy allows multi-color super-resolution images with high spectral sensitivity. While its profile has been steadily growing, it is still under-utilized in biology labs, and the complexity of adoption for existing prohibitive. In this protocol, we provide essential information researchers to implement sSMLM a laboratory setting. We describe how assemble optically align illumination detection paths 3D dual-wedge prism-based instrument. detailed...

To investigate the effects of electro-acupuncture (EA) treatment on regions remote from application, we measured cellular, enzymatic, and transcriptional activities in various internal tissues healthy rats. The EA was applied to well-identified acupoint ST36 leg. After activity natural killer cells spleen, gene expression hypothalamus, antioxidative enzymes liver red blood cells. increased cell spleen by approximately 44%. It also induced genes related pain, including 5-Hydroxytryptamine...

Antireflective structures, inspired from moth eyes, are still reserved for practical use due to their large-area nanofabrication and mechanical stability. Here we report an antireflective optical lens with glass nanoholes. The nanoholes increase light transmission the effect, depending on geometric parameters such as fill factor height. of low effective refractive index achieved by using solid-state dewetting ultrathin silver film, reactive ion etching, wet etching. An film is transformed...

Aim. To investigate whether dyspepsia symptoms differ depending on the presence or absence of cold hypersensitivity in hands and feet (CHHF). Methods. In all, 6044 patients were recruited provided with a questionnaire about CHHF dyspepsia. Based their responses, subjects divided into group (persons who noted sensations; n = 1209) non-CHHF warm intermediate 1744). The groups compared terms usual digestion status, using chi-square tests logistic regression analyses to calculate propensity...

This study was performed to develop questionnaire of cold-heat pattern identification(PI) based on usual symptoms for general people, and we analyzed reliability the questionnaire. We reviewed PI advanced research selected twenty-three items through three time experts meeting. Three hundred fifty nine healthy subjects were joined in this study. As a results, Cronbach’s α 0.79 0.83. According factor analysis about fifteen-chosen questionnaires, each consisted two factors Convergence 56.46%...

By manipulating the spectral dispersion of detected photons, spectroscopic single-molecule localization microscopy (sSMLM) permits concurrent high-throughput single-molecular analysis and imaging. Despite its promising potential, using discrete optical components managing delicate balance between spatial compromise performance, including non-uniform dispersion, high transmission loss grating, alignment demands, reduced precision. We designed a dual-wedge prism (DWP)-based monolithic imaging...

A highly flexible elastomeric membrane with antireflective structures, which enhances light transmittance over the visible range, is successfully integrated into tunable deformable lens for endoscopic application.

A new flavonoid, 2,″4″-O-diacetylquercitrin (1), along with six known flavonoids (2–7) were isolated from the aerial parts of Melastoma sanguineum. The structure flavonoid was established by extensive spectroscopic studies and chemical evidence. inhibitory effects compounds (1–7) on advanced glycation end-products (AGEs) formation rat lens aldose reductase (RLAR) in vitro examined. Of tested compounds, compound 1 strongest inhibitor AGEs, an IC50 11.46±0.44 µm. In RLAR assay, all exhibited...