A5012328392- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Thermography and Photoacoustic Techniques
- Luminescence and Fluorescent Materials
- Optical Imaging and Spectroscopy Techniques
- Cell Image Analysis Techniques
- Molecular Sensors and Ion Detection
- Single-cell and spatial transcriptomics
- Venous Thromboembolism Diagnosis and Management
- Layered Double Hydroxides Synthesis and Applications
- Biotin and Related Studies
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Thermal Regulation in Medicine
- Synthesis and Properties of Aromatic Compounds
- Climate variability and models
- Click Chemistry and Applications
- RNA Research and Splicing
- Coastal wetland ecosystem dynamics
- Advanced Materials and Mechanics
- Bladder and Urothelial Cancer Treatments
- Adsorption and biosorption for pollutant removal
- Supramolecular Chemistry and Complexes
- Cellular Mechanics and Interactions
Duke University
2018-2024
Southeast University
2022-2024
Nantong University
2023-2024
Yangpu Hospital of Tongji University
2024
Tongji University
2023-2024
Shanghai Ninth People's Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
University of Illinois Urbana-Champaign
2004-2024
Jiangsu Normal University
2024
Southeast University
2024
The development of chiral optical active materials with switchable circularly polarized luminescence (CPL) signals remains a challenge. Here an azoarene-based molecular switch, (S, R, S)-switch 1 and (R, R)-switch 2, are designed prepared (R)-binaphthyl azo group as photosensitive moiety two (S)- or fluorescent molecules opposite the same handedness moieties. Both switches exhibit reversible trans/cis isomerization when irradiated by 365 nm UV light 520 green in solvent liquid crystal (LC)...
Abstract Polymer-based circularly polarized luminescence (CPL) materials with the advantage of diversified structure, easy fabrication, high thermal stability, and tunable properties have garnered considerable attention. However, adequate precise tuning over CPL in polymer-based remains challenging due to difficulty regulating chiral structures. Herein, visualized full-color is achieved by doping red, green, blue quantum dots (QDs) into reconfigurable phase liquid crystal elastomers...
Abstract Unlike amyloid aggregates, amorphous protein aggregates with no defined structures have been challenging to target and detect in a complex cellular milieu. In this study, we rationally designed sensors of aggregation from aggregation‐induced‐emission probes (AIEgens). Utilizing dicyanoisophorone as model AIEgen scaffold, first sensitized the fluorescence AIEgens nonpolar viscous environment mimicking interior aggregated proteins. We identified generally applicable moiety...
Protein aggregation is a biological phenomenon in which aberrantly processed or mutant proteins misfold and assemble into variety of insoluble aggregates. Decades studies have delineated the structure, interaction, activity either their natively folded structures aggregates such as amyloid fibrils. However, intermediate species exist between these two extreme states protein folding landscape. Herein, we collectively term misfolded oligomers, including soluble oligomers preamyloid that are...
Hypoxia, a low tissue oxygenation condition caused by insufficient oxygen supply, leads to potentially irreversible damage, such as brain infarction during stroke. Intravascular has long been used photoacoustic imaging, among other imaging modalities, study hypoxia. However, intravascular describes only the supply via microcirculation, which does not directly reflect amount of free available for metabolism in interstitial fluid. Therefore, fully understand hypoxia, it is highly desirable...
Abstract Covalent chemical reactions to modify aggregated proteins are rare. Here, we reported covalent Michael addition can generally occur upon protein aggregation. Such reactivity was initially discovered by a bioinspired fluorescent color‐switch probe mimicking the photo‐conversion mechanism of Kaede protein. This dark with folded but turned on red fluorescence (620 nm) when it non‐covalently bound misfolded proteins. Supported biochemical and mass spectrometry results, chemoselectively...
Abstract Circularly polarized luminescent (CPL) materials have garnered tremendous attention owing to their expanded optical properties beyond emission wavelength and intensity. Among these, the emerging circularly organic ultralong room‐temperature phosphorescence (CP‐OURTP) materialsdemonstrating elegant distinct features are of significant importance for extended lifetime, which represent a novel frontier in research with promising scientific technological applications across diverse...
Invasion and metastasis are the main causes of unfavourable prognosis in patients diagnosed with bladder cancer. The efficacy immunotherapy cancer remains suboptimal due to presence an immunosuppressive microenvironment. novel protein family sequence similarity 171B (FAM171B) has been identified, but its precise role mechanism remain unclear.
Significance The ability to noninvasively detect and track disease biomarkers via photoacoustic imaging (a light-in, sound-out technique) can potentially substitute invasive medical procedures such as a liver biopsy. While achieving this goal have profound impact on management, it is an immense challenge that requires novel chemical tools are sensitive, selective, safe. Here, we report probe designed for Cu(I), which becomes dysregulated in many states. In addition demonstrating vivo...
Photoacoustic tomography (PAT), a hybrid imaging modality that acoustically detects the optical absorption contrast, is promising technology for hemodynamic functions in deep tissues far beyond traditional microscopy. However, most clinically compatible PAT often suffers from poor image fidelity, mostly due to limited detection view of linear ultrasound transducer array. can be improved by employing highly-absorbing contrast agents such as droplets and nanoparticles, which, however, have low...
Recent studies indicate that cavitation may play a vital role in laser lithotripsy. However, the underlying bubble dynamics and associated damage mechanisms are largely unknown. In this study, we use ultra-high-speed shadowgraph imaging, hydrophone measurements, three-dimensional passive mapping (3D-PCM), phantom test to investigate transient of vapor bubbles induced by holmium:yttrium aluminum garnet their correlation with solid damage. We vary standoff distance (SD) between fiber tip...
Abstract The global burden of colorectal cancer (CRC) has rapidly increased in recent years. Dysregulated cholesterol homeostasis facilitated by extracellular matrix (ECM) remodeling transforms the tumor microenvironment. Collagen I, a major with ECM component is highly expressed tumors infiltrative growth. Although oxysterol binding protein (OSBP)-related proteins accommodate tumorigenesis, OSBPL2, which usually involved deafness, not associated CRC progression. Therefore, we aimed to...
3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development 3D-PACT requires high-performance acoustic sensors a small size, detection bandwidth, sensitivity. In this work, we present new high-frequency system that uses micro-ring resonator (MRR) as the sensor. MRR sensor size 80 μm diameter, was fabricated using nanoimprint lithography technology. Using...
The increased activity of the mTOR pathway in bladder cancer has been extensively studied, but no satisfactory inhibitor found cancer. role AZD8055, a second-generation inhibitor, not reported Herein, we investigated effects AZD8055 on cells and their interaction with macrophages vivo vitro. In four cell lines, phosphorylation mTOR, AKT S6K1 was suppressed by AZD8055. inhibited proliferation induced G1 cell-cycle arrest apoptosis concentration-dependent manner. also inhibits migration...