A5101422795- Fungal Biology and Applications
- Cancer, Lipids, and Metabolism
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Bioactivity Studies
- Bioactive Natural Diterpenoids Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Colorectal and Anal Carcinomas
- Bladder and Urothelial Cancer Treatments
- Cell death mechanisms and regulation
- Chromatography in Natural Products
- Case Reports on Hematomas
- Cancer, Hypoxia, and Metabolism
- Vascular Procedures and Complications
- Mycotoxins in Agriculture and Food
- Radiomics and Machine Learning in Medical Imaging
- Alkaloids: synthesis and pharmacology
- Cholesterol and Lipid Metabolism
- Autophagy in Disease and Therapy
- Phytochemistry and Biological Activities
- Colorectal Cancer Screening and Detection
- Crystallography and molecular interactions
- Healthcare and Venom Research
Binzhou People's Hospital
2025
Yangpu Hospital of Tongji University
2021-2024
Tongji University
2021-2024
University of Electronic Science and Technology of China
2023
Chinese Academy of Sciences
2013-2017
Institute of Microbiology
2013-2017
University of Chinese Academy of Sciences
2017
Abstract Background Colorectal cancer (CRC) is one of the most malignant tumors with high incidence, yet its molecular mechanism not fully understood, hindering development targeted therapy. Metabolic abnormalities are a hallmark cancer. Targeting dysregulated metabolic features has become an important direction for modern anticancer In this study, we aimed to identify new enzyme that promotes proliferation CRC and examine related mechanisms. Methods We performed RNA sequencing tissue...
The pro-apoptotic Bax and Bak proteins are considered central to apoptosis, yet apoptosis occurs in their absence. Here, we asked whether the mitochondrial protein VDAC1 mediates independently of Bax/Bak. Upon screening a fungal secondary metabolite library for compounds inducing Bax/Bak-deficient mouse embryonic fibroblasts, identified cyathin-R, new cyathane diterpenoid compound able activate absence Bax/Bak via promotion oligomerization that cytochrome c release....
Two new heterodimeric sesquiterpenes, sterhirsutins C (1) and D (2), along with eight sesquiterpenoid derivatives, E–-L (3–10), were isolated from the culture of Stereum hirsutum. The absolute configuration 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 2 possessed an unprecedented chemical skeleton 5/5/5/6/9/4 fused ring system. Compound 10 is first sesquiterpene coupled xanthine moiety. 1–10 showed cytotoxicity against K562 HCT116 cell lines. 9 induced autophagy...
Abstract The global burden of colorectal cancer (CRC) has rapidly increased in recent years. Dysregulated cholesterol homeostasis facilitated by extracellular matrix (ECM) remodeling transforms the tumor microenvironment. Collagen I, a major with ECM component is highly expressed tumors infiltrative growth. Although oxysterol binding protein (OSBP)-related proteins accommodate tumorigenesis, OSBPL2, which usually involved deafness, not associated CRC progression. Therefore, we aimed to...
Background While transarterial chemoembolization (TACE) has been performed using both the transfemoral approach (TFA) and transradial (TRA) to date, relative superiority of these techniques remains uncertain. This study aimed evaluate clinical efficacy, radiation exposure, safety associated with TRA- TFA-based TACE procedures in patients inoperable hepatocellular carcinoma (HCC). Methods compared outcomes consecutive HCC who were treated via TFA- or TRA-based between January 2020 August...
Five new hispidin derivatives, phaeolschidins A-E (1-5), as well two known natural products, pinillidine (6) and (7), were isolated from the fruiting bodies of Phaeolus schweinitzii collected in Tibetan Plateau. The structures compounds elucidated by spectroscopic methods. Phaeolschidins A-D (1-4) are bishispidins. Phaeolschidin E (5) is a class derivative which one pyrrolidin-2-one moiety was linked to C-3 hispidin. antioxidant activity 1-7 evaluated using three methods: DPPH scavenging...
Three highly modified indole alkaloids, versicoamides F–H (1–3), together with seven known alkaloids (4–10) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds determined by analysis NMR and MS spectroscopic data. absolute configurations 1 2 assigned single-crystal X-ray diffraction experiments. Compounds showed weak antiproliferative activity against H460 cell line. 1–3 represent a class natural product hybrids chemical skeletons.
Colon adenocarcinoma (COAD) is one of the most prevalent malignancies, with poor prognosis and lack effective treatment targets. Squalene synthase (FDFT1) an upstream enzyme squalene epoxidase (SQLE) in cholesterol biosynthesis. In a previous study, we revealed that SQLE promotes colon cancer cell proliferation vitro vivo. Here, investigate prognostic value FDFT1 stage I-III COAD explore potential underlying mechanisms. was significantly upregulated positively correlated differentiation...
Stool DNA (sDNA) methylation analysis is a promising, noninvasive approach for colorectal cancer screening; however, reliable biomarkers detecting early-stage colon (ECC) are lacking, particularly in the Chinese population.To identify novel stool-based assay that can improve effectiveness of ECC screening.A blinded case-control study was performed using archived stool samples from 125 patients, and control subjects with normal colonoscopy. The cohort randomly divided into training test sets...
Abstract Ganoboninones A‐F (I)‐(IV) possessing an interesting tetradecahydrobenzo[4,5]indeno[1,7a‐c]furan backbone are isolated along with three known compounds, ganoboninketals A‐C, from the fruiting bodies of medicinal mushroom Ganoderma boninense.