A5063162977- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasonics and Acoustic Wave Propagation
- Liver Disease Diagnosis and Treatment
- Elasticity and Material Modeling
- Electrical and Bioimpedance Tomography
- Flow Measurement and Analysis
- Luminescence Properties of Advanced Materials
- Advanced MRI Techniques and Applications
- Perovskite Materials and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Health and Disease Prevention
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- AI in cancer detection
- Tendon Structure and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Optical Coherence Tomography Applications
- Body Composition Measurement Techniques
- Liver Diseases and Immunity
- Shoulder Injury and Treatment
- Nerve Injury and Rehabilitation
- Spectroscopy Techniques in Biomedical and Chemical Research
Mayo Clinic
2016-2025
Mayo Clinic in Arizona
2016-2025
WinnMed
2007-2024
Northwest A&F University
2020-2024
Mayo Clinic in Florida
2013-2024
China National Nuclear Corporation
2022-2024
Chengdu Medical College
2022-2024
University of Illinois Urbana-Champaign
2019-2023
Texas A&M University
2023
Illinois College
2023
Characterization of tissue elasticity (stiffness) and viscosity has important medical applications because these properties are closely related to pathological changes. Quantitative measurement is more suitable than qualitative (i.e., mapping with a relative scale) viscoelasticity for diagnosis diffuse diseases where abnormality not confined local region there no normal background provide contrast. Shearwave dispersion ultrasound vibrometry (SDUV) uses shear wave propagation speed measured...
The propagation speed of shear waves is related to frequency and the complex stiffness (shear elasticity viscosity) medium. A method presented solve for viscosity a homogeneous medium by measuring wave dispersion. Harmonic radiation force, introduced modulating energy density incident ultrasound, used generate cylindrical various frequencies in measured from phase shift detected over distance propagated. Measurements at multiple are fit with theoretical model Experiments gelatin phantoms...
To investigate the value of viscosity measured with ultrasonographic (US) elastography in liver fibrosis staging and to determine whether use a viscoelastic model estimate elasticity can improve its accuracy staging.The study, which was performed from February 2010 March 2011, compliant HIPAA approved by institutional review board. Written informed consent obtained each subject. Ten healthy volunteers (eight women two men aged 27-55 years) 35 patients disease (17 18 19-74 were studied using...
Super-resolution ultrasound microvessel imaging with contrast microbubbles has recently been proposed by multiple studies, demonstrating outstanding resolution high potential for clinical applications. This paper aims at addressing the noise issue in vivo human super-resolution ultrafast plane-wave imaging. The rich spatiotemporal information provided presents features that allow microbubble signals to be separated from background noise. In addition, high-frame-rate recording of data enables...
Robust clutter filtering is essential for ultrasound small vessel imaging. Eigen-based techniques have recently shown great improvement in rejection over conventional filters animals. However, vivo human imaging, eigen-based can be challenging due to the complex spatially-varying tissue and noise characteristics. To address this challenge, we present a novel block-wise adaptive singular value decomposition (SVD) based technique. The proposed method divides global plane wave data into...
Fast and accurate tissue elasticity imaging is essential in studying dynamic mechanical properties. Various ultrasound shear techniques have been developed the last two decades. However, to reconstruct a full field-of-view 2-D map, multiple data acquisitions are typically required. In this paper, novel technique, comb-push elastography (CUSE), introduced which only one rapid acquisition (less than 35 ms) needed wave speed map (40 × 38 mm). Multiple unfocused beams arranged comb pattern...
Abstract Super-resolution ultrasound localization microscopy (ULM), based on and tracking of individual microbubbles (MBs), offers unprecedented microvascular imaging resolution at clinically relevant penetration depths. However, ULM is currently limited by the requirement dilute MB concentrations to ensure spatially sparse events for accurate tracking. The corresponding long acquisition times (tens seconds or several minutes) accumulate sufficient isolated full reconstruction...
An interlaboratory study of shear wave speed (SWS) estimation was performed. Commercial elastography systems from Fibroscan, Philips, Siemens and Supersonic Imagine, as well several custom laboratory systems, were involved. Fifteen sites included in the study. CIRS manufactured donated 11 pairs phantoms designed for purposes this investigation. Dynamic mechanical tests equivalent phantom materials also The results demonstrate that there is very good agreement among SWS but are sources bias...
Objective The diagnosis of autoimmune pancreatitis (AIP) is challenging. Sonographic and cross-sectional imaging findings AIP closely mimic pancreatic ductal adenocarcinoma (PDAC) techniques for tissue sampling are suboptimal. These limitations often result in delayed or failed diagnosis, which negatively impact patient management outcomes. This study aimed to create an endoscopic ultrasound (EUS)-based convolutional neural network (CNN) model trained differentiate from PDAC, chronic (CP)...
Contrast microbubble (MB)-based super-resolution ultrasound microvessel imaging (SR-UMI) overcomes the compromise in conventional between spatial resolution and penetration depth has been successfully applied to a wide range of clinical applications. However, translation SR-UMI remains challenging due limited number MBs detected within given accumulation time. Here, we propose Kalman filter-based method for robust MB tracking improved blood flow speed measurement with reduced numbers MBs. An...
Abstract Non-invasive detection of microvascular alterations in deep tissues vivo provides critical information for clinical diagnosis and evaluation a broad-spectrum pathologies. Recently, the emergence super-resolution ultrasound localization microscopy (ULM) offers new possibilities imaging microvasculature at capillary level. Currently, utility ULM on scanners is hindered by technical limitations, such as long data acquisition time, high microbubble (MB) concentration, compromised...
Two-dimensional shear-wave elastography presents 2-D quantitative shear elasticity maps of tissue, which are clinically useful for both focal lesion detection and diffuse disease diagnosis. Realization on conventional ultrasound scanners, however, is challenging because the low tracking pulse-repetition-frequency (PRF) these systems. Although some clinical research platforms support software beamforming plane-wave imaging with high PRF, majority current systems do not have capability, a...
Ultrasound and magnetic resonance elastography techniques are used to assess mechanical properties of soft tissues. Tissue stiffness is related various pathologies such as fibrosis, loss compliance, cancer. One way perform measuring shear wave velocity propagating waves in tissue induced by intrinsic motion or an external source vibration, relating the elasticity. All tissues inherently viscoelastic ignoring viscosity biases velocity-based estimates elasticity ignores a potentially important...
Abstract Ultrasound localization microscopy (ULM) permits the reconstruction of super-resolved microvascular images at clinically relevant penetration depths, which can be potentially leveraged to provide non-invasive quantitative measures tissue hemodynamics and hypoxic status. We demonstrate that ULM microbubble data processing methods, applied acquired with a Verasonics Vantage 256 system, imaging surrogate biomarker oxygenation This technique was evaluate structure, vascular perfusion,...
A method using pulse echo ultrasound and the Kalman filter is developed for detecting submicron harmonic motion induced by ultrasonic radiation force. The estimates amplitude phase of at desired locations within a tissue region with high sensitivity. generated force expressed as extremely small oscillatory Doppler frequency shifts in fast time (A-line) echoes, which are difficult to estimate. In slow (repetitive echoes) also presented shifts, from can be estimated least mean squared error...
Ultrasound tissue harmonic imaging is widely used to improve ultrasound B-mode quality thanks its effectiveness in suppressing artifacts associated with reverberation, phase aberration, and clutter noise. In shear wave elastography (SWE), because the motion signal extracted from signal, these noise sources can significantly deteriorate tracking process consequently result noisy biased detection. This situation exacerbated vivo SWE applications such as heart, liver, kidney. paper, therefore,...