A5100460558- Trace Elements in Health
- Prostate Cancer Treatment and Research
- Sperm and Testicular Function
- Adipokines, Inflammation, and Metabolic Diseases
- Selenium in Biological Systems
- Nutritional Studies and Diet
- Heavy Metal Exposure and Toxicity
- Fatty Acid Research and Health
- Iron Metabolism and Disorders
- Prostate Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Renal Diseases and Glomerulopathies
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Chronic Kidney Disease and Diabetes
- Acute Myeloid Leukemia Research
- Phagocytosis and Immune Regulation
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Natural Compounds in Disease Treatment
- Cancer, Hypoxia, and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Liver Disease Diagnosis and Treatment
- Glutathione Transferases and Polymorphisms
- Gout, Hyperuricemia, Uric Acid
Chongqing Medical University
2016-2025
Children's Hospital of Chongqing Medical University
2023-2025
Chongqing Maternal and Child Health Hospital
2023-2025
Hospital of Hebei Province
2024-2025
Southern Medical University
2014-2024
West China Hospital of Sichuan University
2022-2024
Sichuan University
2022-2024
Nanfang Hospital
2018-2024
National Institutes of Health
2024
St. Jude Children's Research Hospital
2024
Experimental data suggest that long-chain n–3 polyunsaturated fatty acids found in fish have antiarrhythmic properties, and a randomized trial suggested dietary supplements of may reduce the risk sudden death among survivors myocardial infarction. Whether are also associated with those without history cardiovascular disease is unknown.
Asthenozoospermia (ASZ) accounts for about 20-40% of male infertility, and genetic factors, contributing to 30-40% the causes ASZ, still need further exploration. Radial spokes (RSs), a T-shaped macromolecular complex, connect peripheral doublet microtubules (DMTs) central pair (CP), forming CP-RS-DMT structure regulate beat frequency amplitude sperm flagella. To date, many components RSs their functions in human flagella remain unclear. We recruited cohort 323 infertile males with ASZ...
A polymorphism in the gene for alcohol dehydrogenase type 3 (ADH3 ) alters rate of metabolism. We investigated relation among ADH3 polymorphism, level consumption, and risk myocardial infarction a nested case–control study based on data from prospective Physicians' Health Study.
We assessed the relationship between sleep duration, snoring and colorectal cancer risk. Prospective cohort studies. United States. A total of 30,121 men aged 41 to 79 years in Health Professionals Follow-up Study 76,368 women 40 73 Nurses' Study. None. queried information on duration 1986/87. Cox proportional hazards regression models were used estimate multivariable hazard ratios (HRs, 95% CIs). documented 1,973 incident cases (709 1,264 women) over a 22-year follow-up period. Compared an...
Pediatric intracranial ependymomas are a heterogeneous group of neoplasms with unpredictable clinical and biologic behavior. As part ongoing studies to identify potential therapeutic markers, we analyzed the role human telomere reverse transcriptase (hTERT; catalytic subunit telomerase) expression as prognostic marker for this disease.Primary that were resected at our institution between 1986 2004 identified through pathology oncology databases. A tissue array was constructed from patient...
Abstract The role of selenium in prostate cancer (PCa) risk remains controversial, but many epidemiologic studies suggest an inverse association with more aggressive disease. A recently discovered selenoprotein, SEP15, which is highly expressed the prostate, may play a either independently or by modifying effects selenium. We genotyped four common single-nucleotide polymorphisms capturing variation (frequency >5%; R2 > 0.8) within as well rs5859 3′ untranslated region,...
The beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) on psoriasis have been reported in rats, mice and humans, but the specific mechanisms involved not well defined. present study utilized fat-1 mouse, a transgenic model that can endogenously convert n-6 FAs into PUFAs, to directly determine if outcomes were correlated with PUFAs. Wild-type (WT) mice, which treated daily imiquimod (IMQ) cream or control shaved right ear dorsal skin, fed same diet. severity inflammation skin was...
Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, injection of factors these secrete could be effective, but conditioned medium (CM) remains controversial.In this study, we cultured mesenchymal (MSCs) and then transplanted them into ischemia-reperfusion (I/R) model. CM was also injected mice, histological changes, level cell proliferation, loss...
Abstract Preeclampsia (PE) is considered as a disease of placental origin. However, the specific mechanism abnormalities remains elusive. This study identified thrombospondin‐1 (THBS1) downregulated in preeclamptic placentae and negatively correlated with blood pressure. Functional studies show that THBS1 knockdown inhibits proliferation, migration, invasion increases cycle arrest apoptosis rate HTR8/SVneo cells. Importantly, silencing induces necroptosis cells, accompanied by release...
The association of baseline fatty acid composition in plasma cholesterol esters with 6-year incidence hypertension was examined middle-aged Minneapolis participants the Atherosclerosis Risk Communities (ARIC) Study (1987–1995). Compared those who were never hypertensive (n = 1, 975), incident hypertensives 413) had statistically significantly higher levels palmitic (16: 0) and palmitoleic 1n7) acids but lower linoleic (18: 2n6) polyunsaturated/saturated ratio (P/S ratio). Among...
Mice lacking TYRO3, AXL and MER (TAM) receptor tyrosine kinases (RTKs) are male sterile. The mechanism of TAM RTKs in regulating fertility remains unknown. In this study, we analyzed more detail the testicular phenotype triple mutant (TAM(-/-)) mice with an effort to understand mechanism. We demonstrate that three cooperatively regulate fertility, appears be important than TYRO3. TAM(-/-) testes showed a progressive loss germ cells from elongated spermatids spermatogonia. Young adult...