A5100451212- Mesenchymal stem cell research
- Renal Diseases and Glomerulopathies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Tissue Engineering and Regenerative Medicine
- Eosinophilic Disorders and Syndromes
- Neurogenesis and neuroplasticity mechanisms
- Vasculitis and related conditions
- Nerve injury and regeneration
- Chronic Myeloid Leukemia Treatments
- Parathyroid Disorders and Treatments
- Trace Elements in Health
- Cardiovascular Function and Risk Factors
- Electrospun Nanofibers in Biomedical Applications
- Pregnancy and Medication Impact
- Acute Kidney Injury Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heavy Metal Exposure and Toxicity
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Blood groups and transfusion
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
Second Affiliated Hospital of Jilin University
2011-2025
Hainan Medical University
2022-2025
Shanxi Medical University
2025
Shenzhen Institutes of Advanced Technology
2025
Chinese Academy of Sciences
2025
Second Affiliated Hospital of Harbin Medical University
2005-2024
Hainan Center for Disease Control & Prevention
2024
Anhui University of Science and Technology
2022-2024
Harbin Medical University
2006-2024
Beijing University of Technology
2024
Abstract Increasing evidence from human and laboratory studies showed the effect of zinc ( Zn ) on diabetic complications. Nuclear factor‐erythroid 2‐related factor 2 (Nrf2) plays important role in prevention oxidative damage. This study was to define whether statues (deficiency or supplement) affect Nrf2 expression function, also damage severity renal tubular HK 11) cells exposed high glucose HG with palmitate (Pal) kidney mice induced by multiple low‐dose streptozotocins. For deficiency...
Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, injection of factors these secrete could be effective, but conditioned medium (CM) remains controversial.In this study, we cultured mesenchymal (MSCs) and then transplanted them into ischemia-reperfusion (I/R) model. CM was also injected mice, histological changes, level cell proliferation, loss...
<b><i>Background:</i></b> M-type phospholipase A<sub>2</sub> receptor (PLA<sub>2</sub>R) has been identified as the major target antigen in idiopathic membranous nephropathy (IMN). However, role of glomerular PLA<sub>2</sub>R (gPLA<sub>2</sub>R) and associations serum anti-PLA<sub>2</sub>R antibody (sPLA<sub>2</sub>R-Ab) titre with diagnosis, treatment prognosis IMN need to be further...
Dental pulp stem cells (DPSCs) are considered as an ideal cell source for the treatment of neurological diseases. In this study, we evaluated therapeutic potency DPSCs and brain-derived neurotrophic factor (BDNF) in focal cerebral ischemia using animal models. Following middle artery occlusion (MCAO), rats were randomized into four groups: BDNF, DPSCs, DPSCs+BDNF controls injected with saline. transplanted BDNF was group via tail vein. The fate rat brains immunofluorescence,...
Abstract Background Mesenchymal stem cells (MSCs) exert anti-diabetic effects and improve long-term complications via secretory that regulate macrophage polarisation attenuate inflammation. Enhancing the efficacy of MSCs needs to be explored further. The in vitro culture microenvironment influences profile MSCs. Therefore, we hypothesised a diabetic would promote secretion cytokines responsible for polarisation, further attenuating systemic inflammation enhancing on type 2 diabetes (T2D)...
Abstract Salt-sensitive hypertension (SSHT) leads to kidney interstitial fibrosis. However, the potential mechanisms leading renal fibrosis have not been well investigated. In present study, Dahl salt-sensitive (DS) rats were divided into three groups: normal salt diet (DSN), high (DSH) and treated with hydrochlorothiazide (HCTZ) (DSH + HCTZ). A significant increase in systolic blood pressure (SBP) was observed 3 weeks after initiating diet, marked histological alterations DSH rats. showed...
Background/Aims: Ischemic stroke is a major cause of disability and mortality worldwide, while effective restorative treatments are limited at present. Stem cell transplantation holds therapeutic potential for ischemic vascular diseases may provide an opportunity neural regeneration. Dental pulp stem cells (DPSCs) origin from crest have neuro-ectodermal features including proliferation multilineage differentiation potentials. Methods: The rat model middle cerebral artery occlusion (MCAO) was...
Coal worker's pneumoconiosis (CWP) is a common occupational disease that coal miners are highly susceptible due to long-term exposure dust particles (CDP). CWP can induce the accumulation of immune cells surrounding bronchioles and alveoli in lungs, resulting pulmonary fibrosis compromised function. Using single-cell RNA sequencing (scRNA-Seq), our previous studies disclose CDP triggers heterogeneity transcriptional profiles mouse pneumoconiosis, while Vitamin D3 (VitD3) supplementation...
Introduction: A new and non-invasive technology of left ventricular pressure-strain loop (LV-PSL) has recently been used to provide information on myocardial work (MW) identify subtle modifications in cardiac function. This study aimed use LV-PSL for early identification changes LV structure MW patients with end-stage renal disease (ESRD). Methods： Seventy-two ESRD were divided into two groups based undergoing maintenance hemodialysis (MHD), namely the dialysis group (ESRD-D group)...
To identify the epidemiology and pathological types of kidney diseases their changes during past decade, in a population from Northeast China.We retrospectively analysed clinical renal data 4910 patients who received biopsies Second Hospital Jilin University 2008 to 2017.Males more than females (p < 0.001). The average age 0.001) percentage elderly increased over time. were primary glomerulonephritis (PGN, 73.2%), secondary (SGN, 23.7%), tubular-interstitial nephropathy (TIN, 2.8%),...
Human placenta-derived mesenchymal stem cells (pMSCs) are considered a good source for cell therapy. The purpose of this study was to observe whether the transplantation human pMSCs would affect treatment lupus nephritis (LN)-prone MRL/lpr mice. Multiple injections (at 16th, 18th, and 20th week age) 1 × 10 6 were administered. Urine collected evaluate proteinuria urine creatinine levels. Blood measurement serum antinuclear antibody (ANA) anti-double-stranded DNA (dsDNA) Renal tissues...
Cardiovascular complications remain a leading cause of mortality in patients with end-stage kidney disease undergoing dialysis. This study aimed to evaluate differences left atrial (LA) structure and function between hemodialysis peritoneal dialysis using four-dimensional automatic quantification (4D Auto LAQ) technology. included 125 disease, categorized into (n = 69) 56) groups. Conventional echocardiography 4D LAQ were used assess LA volume strain parameters. Differences groups analyzed....
Background: Epidemiological research and meta-analyses of published data have shown that biomass smoke (BS) is a risk factor for chronic obstructive pulmonary disease (COPD). However, the link between BS COPD lacks experimental confirmation. Objectives: To verify whether can induce pathologic changes systemic oxidative stress, which may be relevant to development emphysema bronchitis in rats. Methods: Rats were exposed BS, cigarette (CS), or clean air (sham) 14 weeks. During exposure, O2,...