A5074249857- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Consumer Attitudes and Food Labeling
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Global Public Health Policies and Epidemiology
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Disease and Adiposity
- Coffee research and impacts
- Cardiovascular Health and Risk Factors
- Genetic Associations and Epidemiology
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Health and Lifestyle Studies
- Nutrition, Genetics, and Disease
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
EsSALUD
2024
Harvard University
2015-2024
Universidad Hispanoamerica
2015-2024
Universidade Federal de Goiás
2024
Brigham and Women's Hospital
2005-2016
Tufts University
1987-2016
Harvard Global Health Institute
2015
Universidad de Costa Rica
2004-2014
Boston University
2000-2013
Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud
2013
Experimental data suggest that long-chain n–3 polyunsaturated fatty acids found in fish have antiarrhythmic properties, and a randomized trial suggested dietary supplements of may reduce the risk sudden death among survivors myocardial infarction. Whether are also associated with those without history cardiovascular disease is unknown.
Decreased plasma low density lipoprotein (LDL) particle size has been associated with premature coronary artery disease (CAD). We examined LDL by 2-16% gradient gel electrophoresis in 275 men CAD (greater than 75% cross-sectional-area stenosis) and 822 controls. Seven major bands (with LDL-1 [d = 1.025-1.033 g/ml] being the largest LDL-7 1.050-1.063 g/ml, smallest]) were identified. Because most subjects had two or more adjacent bands, an score was calculated for each subject, relative area...
The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source caffeine, which metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for CYP1A2*1A allele "rapid" caffeine metabolizers, whereas carriers variant CYP1A2*1F "slow" metabolizers.To determine whether CYP1A2 genotype modifies consumption acute nonfatal MI.Cases (n = 2014) with first MI population-based controls living in Costa...
The presence of low molecular weight density lipoprotein (LDL) particles in plasma has been associated with premature coronary artery disease. In this study we have examined factors affecting LDL subfraction distribution as determined by 2% to 16% polyacrylamide-agarose gradient gel electrophoresis whole a normal, primarily middle-aged, population adult male and female participants (n = 280, ages 25 75 years) the Framingham Offspring Study. Seven major bands (LDL-1 LDL-7) were observed...
<h3>Importance</h3> The role of ω-3 polyunsaturated fatty acids for primary prevention coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. <h3>Objective</h3> To evaluate biomarkers seafood-derived eicosapentaenoic acid (EPA; 20:5ω-3), docosapentaenoic (DPA; 22:5ω-3), and docosahexaenoic (DHA; 22:6ω-3) plant-derived α-linolenic (ALA; 18:3ω-3) incident CHD. <h3>Data Sources</h3> A global consortium 19...
Carotenoids, micronutrients in fruits and vegetables, may reduce breast cancer risk. Most, but not all, past studies of circulating carotenoids have found an inverse association with at least one carotenoid, although the specific carotenoid has varied across studies. We conducted a pooled analysis eight cohort comprising more than 80% world's published prospective data on plasma or serum cancer, including 3055 case subjects 3956 matched control subjects. To account for laboratory differences...
Obesity and the associated pathologies including dyslipidemia, insulin resistance, type 2 diabetes, cardiovascular disease constitute a major threat to global human health. Yet, genetic factors that differentially predispose individuals this cluster of are unclear. The fatty acid-binding protein aP2 is cytoplasmic lipid chaperon expressed in adipocytes macrophages. Mice with deficiency partially resistant obesity-induced resistance have lower circulating triglycerides, exhibit marked...
Biomarkers could provide a more accurate measure of long-term intake than questionnaires. Adipose tissue is considered the best indicator essential fatty acid intake, but other tissues may prove equally valid. The authors evaluated ability fasting whole blood, relative to plasma and adipose tissue, reflect intake. Costa Rican men (n = 99) women 101) completed 135-item food frequency questionnaire provided blood samples from 1999 2001. Fatty acids were identified by using capillary gas...
Little is documented about the performance of food frequency questionnaire (FFQ) in US minority groups and populations developing countries. The authors applied a novel technique, method triads, to assess validity reproducibility FFQ among Hispanics. subjects were men (n = 78) women 42) living Costa Rica. Seven 24-hour dietary recalls two interviews (12 months apart) conducted between 1995 1998 estimate intake during past year. Plasma adipose tissue samples collected from all subjects....
High consumption of trans fat has been linked to the risk coronary heart disease (CHD). We assessed hypothesis that higher fatty acid contents in erythrocytes were associated with an elevated CHD a nested case-control study among US women.Blood samples collected from 32,826 participants Nurses' Health Study 1989 1990. During 6 years follow-up, 166 incident cases ascertained and matched 327 controls. Total content was significantly correlated dietary intake (correlation coefficient=0.44,...
Using 2-16% gradient gel electrophoresis, we examined low density lipoprotein (LDL) particle size in relation to plasma lipoproteins 1,168 women and 1,172 men from the Framingham Offspring Study. In addition, studied effect of dietary intake on LDL a subset population. Seven peaks were identified, with largest, 1, being found range 1.019-1.033 g/ml; 2 3 d = 1.033-1.038 4 LDL5 1.038-1.050 smallest, 6 7, 1.050-1.063 g/ml. Seventy-seven percent population had one major at least minor peak....
Abstract Background: Animal models suggest that n-3 fatty acids inhibit prostate cancer proliferation, whereas n-6 promote it, but epidemiologic studies do not uniformly support these findings. Methods: A nested case-control study was conducted among 14,916 apparently healthy men who provided blood samples in 1982. Blood acid levels were determined for 476 diagnosed with during a 13-year follow-up and their matched controls. Conditional logistic regression used to estimate the relative risks...
Background— Intake of long-chain n-3 fatty acids found in fish is low many countries worldwide. α-Linolenic acid could be a viable cardioprotective alternative to these countries. Methods and Results— Cases (n=1819) with first nonfatal acute myocardial infarction population-based controls living Costa Rica matched for age, sex, area residence were studied. Fatty assessed by gas chromatography adipose tissue samples validated food frequency questionnaire specifically designed this population....