A5101729627- Pharmacological Effects of Natural Compounds
- Advancements in Transdermal Drug Delivery
- Phytochemistry and Bioactivity Studies
- Ginseng Biological Effects and Applications
- Acne and Rosacea Treatments and Effects
- Dermatology and Skin Diseases
- Phytochemistry and biological activity of medicinal plants
- Atherosclerosis and Cardiovascular Diseases
- melanin and skin pigmentation
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Drug Solubulity and Delivery Systems
- Bee Products Chemical Analysis
- Radiopharmaceutical Chemistry and Applications
- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Cardiovascular Disease and Adiposity
- Polysaccharides and Plant Cell Walls
Southern Medical University
2018-2025
Huazhong University of Science and Technology
2023-2025
TCM-Intigrated Cancer Center of Southern Medical University
2025
Tsinghua–Berkeley Shenzhen Institute
2024
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
University of Applied Sciences and Arts of Southern Switzerland
2024
Key Laboratory of Guangdong Province
2024
Nanjing Medical University
2017-2024
AGH University of Krakow
2024
Abstract Background Coronary inflammation plays crucial role in type 2 diabetes mellitus (T2DM) induced cardiovascular complications. Both glucose-lowering drug interventions (GLDIS) and glycemic control (GC) status potentially correlate coronary inflammation, as indicated by changes pericoronary adipose tissue (PCAT) attenuation, thus influence risk. This study evaluated the impact of GLDIS GC on PCAT attenuation T2DM patients. Methods retrospective collected clinical data computed...
This study was sought to investigate the chemical composition and antibacterial antiulcerative colitis (UC) effects of essential oil from Pruni Semen (PSEO). A GC-MS assay showed that major compounds in PSEO were products amygdalin hydrolysis, which possessed great anti-inflammatory potential. In vitro experiments demonstrated treatment inhibited activity four kinds intestinal pathogens probably by disrupting cell wall. Further vivo studies administration significantly improved physiological...
Abstract Sigal peptides have garnered remarkable efficacy in rejuvenating photoaged skin and delaying senescence. Nevertheless, their low solubility poor permeability bring about a formidable challenge transdermal delivery. To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) oxymatrine (OMT) with eminent biocompatibility is first prepared. The components ratios inherent forming mechanisms of GA‐OMT (GAO) are optimized by molecular dynamics...
Increasing evidence has highlighted the pivotal role that intimal macrophage (iMΦ) plays in pathophysiology of atherosclerotic plaques, which represents an attractive target for atherosclerosis treatment. In this work, to address insufficient specificity conventional reconstituted high-density lipoprotein (rHDL) iMΦ and its limited cholesterol efflux ability, we designed a hyaluronan (HA)-anchored core-shell rHDL. This nanoparticle achieved efficient iMΦ-targeted drug delivery via...
Licorice flavonoid (LF) is the main component of Glycyrrhizae Radix et Rhizoma, a "medicine food homology" herbal medicine, which has anti-digestive ulcer activity, but mechanism in anti-gastric (GU) remains to be elucidated. In this study, we manifested that LF increased viability human gastric mucosal epithelial (GES-1) cells, attenuated ethanol (EtOH)-induced manifestations, reduced histological injury, suppressed inflammation, and restored barrier GU rats. After therapy, EtOH-induced gut...
An atorvastatin calcium (AT)-loaded dextran sulfate (DXS)-coated core-shell reconstituted high density lipoprotein (rHDL), termed AT-DXS-LP-rHDL, was developed for targeted drug delivery to macrophages and suppression of inflammation via the affinity DXS with scavenge receptor class AI (SR-AI) as well depletion intracellular cholesterol by apolipoprotein A-I (apoA-I)-mediated efflux. These nanoparticles comprising an AT-loaded negatively charged poly(lactide-co-glycolide) (PLGA) core a...
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release permeation from Carbomer 940 (CP) hydrogels with different enhancers, evaluate the relationship between quantitative enhancement efficacy structures of enhancers. An in vitro an experiment solution using porcine skin were performed. We found that Gla-CP hydrogel showed a higher drug retention amount than LicA-CP due solubility medium better miscibility Gla LicA. Enhancers molecular...
Acne vulgaris is one of the most common inflammatory dermatoses in dermatological practice and can affect any gender or ethnic group. Although previous studies, we had found that licorice flavonoids (LCF) play an anti-acne role by inhibiting PI3K-Akt signaling pathways mitochondrial activity, mechanism LCF regulating skin metabolism, serum metabolism microbes still unclear. Here, performed a full spectrum analysis metabolites using UHPLC-Triple TOF-MS. The results showed could treat acne...
Abstract Licorice flavonoids (LCFs) have been widely used in food care and medical treatment due to their significant antioxidant activities. However, the molecular mechanism of activity remains unclear. Therefore, network pharmacology, ADMET, density functional theory (DFT), docking, dynamics (MD) simulation were employed explore effects LCF. The pharmacology ADMET studies showed that active molecules kumatakenin (p K a = 6.18), licoflavonol 6.86), topazolin 6.21) LCF are key components...
Mangrove-derived actinomycetes represent a rich source of novel bioactive natural products in drug discovery. In this study, four new polyene macrolide antibiotics antifungalmycin B-E (
A biofunctional polymer–lipid hybrid high-density lipoprotein-mimicking nanoparticle (HNP) loading anti-miR155 was constructed for combined antiatherogenic effects on macrophages. The HNP consisted of an core condensed by acid-labile polyethylenimine (acid-labile PEI) polymers and a lipid bilayer coat that decorated with apolipoprotein A-1, termed PEI/HNP. PEI synthesized low-molecular-weight glutaraldehyde to reduce the cytotoxicity facilitate nucleic acids escaping from acidic...