A5100712655- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Immune cells in cancer
- Oral microbiology and periodontitis research
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Neonatal Respiratory Health Research
- Antibiotic Resistance in Bacteria
- Nutrition, Health and Food Behavior
- Respiratory viral infections research
- Plant Virus Research Studies
- Pediatric health and respiratory diseases
- Powdery Mildew Fungal Diseases
- Single-cell and spatial transcriptomics
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Immune responses and vaccinations
- Phagocytosis and Immune Regulation
- Antioxidant Activity and Oxidative Stress
- T-cell and B-cell Immunology
- Sleep and related disorders
- Plant Pathogens and Fungal Diseases
- Influenza Virus Research Studies
- Phytochemicals and Antioxidant Activities
Pohang University of Science and Technology
2023-2024
Korea Research Institute of Bioscience and Biotechnology
2020-2022
Chonnam National University
2022
Korea University Medical Center
2015
Konyang University
2012-2014
Konyang University Hospital
2014
Hallym University
2007
Toll-like receptors (TLRs) orchestrate a repertoire of immune responses in macrophages against various pathogens. Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans are two important periodontal In the present study, we investigated TLR signaling regulating cytokine production response to F. A. actinomycetemcomitans. TLR2 TLR4 redundant cytokines (interleukin-6 [IL-6] tumor necrosis factor alpha [TNF-α]) nucleatum- actinomycetemcomitans-infected macrophages. The by infection...
Abstract Adipose tissue (AT) adapts to overnutrition in a complex process, wherein specialized immune cells remove and replace dysfunctional stressed adipocytes with new fat cells. Among recruited AT, lipid-associated macrophages (LAMs) have emerged as key players obesity diseases involving lipid stress inflammation. Here, we show that LAMs selectively express transmembrane 4 L six family member 19 (TM4SF19), lysosomal protein represses acidification through its interaction Vacuolar-ATPase....
Nod-like receptors are a family of innate immune that link cytosolic sensing microbial and danger stimuli to the activation responses. Two receptor members, Nod1 Nod2, recognize bacterial peptidoglycan activate responses via nuclear factor-κB (NF-κB) mitogen-activated protein kinase (MAPK). The function Nod2 has been largely studied in macrophages, but role these other cells remains unclear. In this study, we examined neutrophils. Mice were injected intraperitoneally with thioglycollate,...
Interleukin-10 plays important, yet contrasting, roles in host protection against bacterial infections and the septic response. To determine role of IL-10 defense Acinetobacter baumannii infection, wild-type (WT) IL-10-deficient mice were infected intranasally with bacteria. exhibited increased mortality, severe pathology, excess production proinflammatory cytokines chemokines lungs, burdens bronchoalveolar lavage (BAL) fluids lung homogenates after A. compared to WT mice. Intranasal...
Oxidative modification of LDL is causally involved in the development atherosclerosis and occurs vivo blood as well within vascular wall. The present study attempted to explore whether polyphenolic flavonoids influence monocyte-endothelium interaction lectin-like oxidised receptor 1 (LOX-1) expression early atherosclerosis. flavones luteolin apigenin inhibited THP-1 cell adhesion onto LDL-activated human umbilical vein endothelial cells (HUVEC), while flavanols ( − )epigallocatechin gallate...
Repeated pandemics caused by the influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV) have resulted in serious problems global public health, emphasizing need for broad-spectrum antiviral therapeutics against infections. Here, we show protective effects of long-acting recombinant human interleukin-7 fused with hybrid Fc (rhIL-7-hyFc) major viruses, including virus, SARS-CoV-2, syncytial virus. Administration rhIL-7-hyFc a therapeutic or prophylactic regimen induces...
Prevotella nigrescens is an oral pathogen that frequently observed in the subgingival plaque of periodontitis patients.Interleukin-1β (IL-1β) known to be involved immunopathology periodontal diseases and has been implicated destruction bone.In this study, we investigated mechanism IL-1β production by P. murine bone marrow-derived dendritic cells (BMDCs).Our results showed a host receptor, Toll-like receptor 2 (TLR2), but not TLR4 required for pro-IL-1β induction nucleotide-binding...
Abstract Adipose tissue macrophages are critical players in obesity-induced inflammation and metabolic dysfunction. Here, we identify transmembrane 4 L six family member 19 (TM4SF19) as a gene upregulated adipose obese states. We demonstrate that TM4SF19 is lysosomal membrane protein inhibits vacuolar H+-ATPase activity by interacting with its subunit ATP6V0B. In vitro gain- loss-of-function assays indicate reduces acidification impairs the clearance of dead fat cells. Single-nucleus RNA...