A5074686762- Immune Cell Function and Interaction
- Vibrio bacteria research studies
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Aquaculture disease management and microbiota
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Head and Neck Cancer Studies
- Optical Coatings and Gratings
- Ginseng Biological Effects and Applications
- Antibiotic Resistance in Bacteria
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Mast cells and histamine
- Advanced Measurement and Metrology Techniques
- Sports Performance and Training
- Education and Learning Interventions
- Chemokine receptors and signaling
- Phagocytosis and Immune Regulation
- Cytokine Signaling Pathways and Interactions
- Pineapple and bromelain studies
Rutgers New Jersey Medical School
2025
Rutgers, The State University of New Jersey
2025
Seoul National University
2015-2024
Samsung (South Korea)
2023
Gwangju Institute of Science and Technology
2020
Korea University
1998-2016
Food & Nutrition
2014
Samsung Medical Center
2014
Sungkyunkwan University
2014
Chungbuk National University
2014
The survival rate for head and neck squamous cell carcinoma remains poor despite therapeutic advances over the last two decades. For patients with disease confined to neck, there are major biologically distinct patterns of treatment failures after definitive therapy: recurrence primary development second tumors. Understanding biological basis failure therapy is needed guide adjuvant strategies prevent To determine whether expression p53 protein has prognostic significance and/or associated...
Expression of ectonucleotidase CD39 contributes to the suppressive activity Foxp3+ regulatory T cells (Tregs) by hydrolyzing immunogenic ATP into AMP. The molecular mechanism that drives expression on Tregs remains elusive. We found tumor-infiltrating (Ti-Tregs) failed up-regulate in mice lacking EBI3 subunit IL-27 or IL-27Ra. Mixed bone marrow chimera and vitro studies showed signaling directly Ti-Tregs a STAT1-dependent, but STAT3- T-bet-independent, manner. stimulated with enhanced...
Despite the clinically proven efficacies of immune checkpoint blockades, including anti-cytotoxic T lymphocyte-associated protein 4 antibody (αCTLA-4), low response rate and immune-related adverse events (irAEs) in cancer patients represent major drawbacks therapy. These αCTLA-4 therapy are mainly due to suboptimal activation tumor-specific cytotoxic lymphocytes (CTLs) systemic nonspecific cells. To overcome such drawbacks, is delivered by dendritic cell-derived nanovesicles presenting tumor...
Abstract Adipose tissue (AT) adapts to overnutrition in a complex process, wherein specialized immune cells remove and replace dysfunctional stressed adipocytes with new fat cells. Among recruited AT, lipid-associated macrophages (LAMs) have emerged as key players obesity diseases involving lipid stress inflammation. Here, we show that LAMs selectively express transmembrane 4 L six family member 19 (TM4SF19), lysosomal protein represses acidification through its interaction Vacuolar-ATPase....
Upon encountering allergens, CD4 + T cells differentiate into IL-4-producing Th2 in lymph nodes, which later transform polyfunctional producing IL-5 and IL-13 inflamed tissues. However, the precise mechanism underlying their polyfunctionality remains elusive. In this study, we elucidate pivotal role of NRF2 murine models allergic asthma human cells. We found that an increase reactive oxygen species (ROS) immune infiltrating lungs is necessary for development eosinophilic vivo. Deletion ROS...
Background Multiple types of immune cells producing IL-17 are found in the tumor microenvironment. However, their roles progression and exhaustion CD8 + tumor-infiltrating lymphocytes (TILs) remain unclear. Methods To determine role type 17 immunity tumor, we investigated growth B16F10 melanoma TILs Il17a −/− mice, Cre R26 DTA RORγt inhibitor-treated or respective control mice. Adoptive transfer tumor-specific IL-17-producing T was performed B16F10-bearing congenic Anti-CD4 anti-Ly6G...
S-Allylcysteine (SAC), produced in large amounts during the aging process of garlic via enzymatic hydrolysis, is known as a key compound responsible for multiple pharmacological activities aged black garlic. This study investigated effects enzyme- and high hydrostatic pressure (HHP)-assisted extraction on content bioactive compounds, including SAC, juice (BGJ) evaluated antidiabetic SAC-enriched BGJ streptozotocin (STZ)-treated mice. The increased contents total polyphenols, flavonoids...
Disruption of colonic homeostasis caused by aberrant M1/M2 macrophage polarization and dysbiosis contributes to inflammatory bowel disease (IBD) pathogenesis. However, the molecular factors mediating are not well characterized. Here, we found that Ninjurin1 (Ninj1) limits colon inflammation regulating microbiota composition under homeostatic conditions during colitis development. Ninj1 deletion in mice induced hypersusceptibility colitis, with increased prevalence colitogenic Prevotellaceae...
For successful infection of their hosts, pathogenic bacteria recognize host-derived signals that induce the expression virulence factors in a spatiotemporal manner. The fulminating food-borne pathogen Vibrio vulnificus produces cytolysin/hemolysin protein encoded by vvhBA operon, which is factor preferentially expressed upon exposure to murine blood and macrophages. Fe-S cluster containing transcriptional regulator IscR activates operon response nitrosative stress iron starvation, during...
Liver X receptor (LXR) is a critical regulator of cholesterol homeostasis that inhibits T cell (TCR)-induced proliferation by altering intracellular sterol metabolism. However, the mechanisms which LXR regulates helper subset differentiation remain unclear. Here, we demonstrate crucial negative follicular (Tfh) cells in vivo. Both mixed bone marrow chimera and antigen-specific adoptive cotransfer studies show specific increase Tfh among LXRβ-deficient CD4 + population response to...
Tetrasubstituted carbon containing two different halogen substituents was constructed in a single-step operation by utilizing the carbene-like reactivity of dioxaphospholene through tandem reaction electrophilic and nucleophilic halogenating reagents. It crucial to devise non-dealkylatable phosphoramidite, which enabled efficient formation geminal chlorofluorides from various 1,2-diketones with (PhSO2)2NF n-Bu4NCl. In addition, selective functionalization chlorine substituent demonstrated,...
Among diverse helper T-cell subsets, Th17 cells appear to be pathogenic in autoimmune diseases, and thus, targeting could beneficial for the treatment of diseases humans. Ginsenoside Rg3 is one most potent components Korean Red Ginseng (KRG; Panax ginseng Meyer) ameliorating inflammatory responses. However, role Th17-mediated autoimmunity unclear. We found that significantly inhibited differentiation from naïve precursors a dendritic cell (DC)–T co-culture system. While minimally affected...
Abstract Pathogenic conversion of Th17 cells into multifunctional helper T or Th1 contributes to the pathogenesis autoimmune diseases; however, mechanism regulating plasticity remains unclear. Here, we found that expressed latent TGF-β1 in a manner dependent on autocrine TGF-β1. By employing IL-17-producing cell-specific Tgfb1 conditional knockout and fate-mapping systems, demonstrated TGF-β1-deficient are relatively susceptible becoming IFN-γ producers through IL-12Rβ2 IL-27Rα upregulation....
Enteropathogenic bacteria have evolved multiple TCSs to recognize and appropriately respond host environments. CAMP is one of the inherent barriers that pathogens encounter during course infection.
Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are possess anti-inflammatory activities. How they impact helper T cell-mediated responses not fully explored. In this study, we attempted evaluate the effect extract (KRGE) Rg3 on Th1 cell responses. Using well-characterized in vitro differentiation systems, examined effects KRGE or enhanced Th1-inducing...
Transforming growth factor beta 1 (TGF-β1) is an immunosuppresive cytokine that plays essential role in immune homeostasis. It well known regulatory T (Treg) cells express TGF-β1; however, the of autocrine TGF-β1 development, function, and stability Treg remains poorly understood. We found cell-derived was not required for development thymic mice, but played a expression latency-associated peptide optimal suppression naïve cell proliferation vitro. Moreover, frequency significantly reduced...
A multifunctional autoprocessing repeats-in-toxin (MARTX) toxin plays an essential role in the virulence of many pathogens, including a fulminating human pathogen Vibrio vulnificus H-NS and HlyU repress derepress expression MARTX gene rtxA V. vulnificus, respectively. However, little is known about other regulatory proteins environmental signals involved regulation. In this study, we found that leucine-responsive protein (Lrp) activates by binding directly specifically to promoter, P Phased...
The transcriptional activator AphB has been implicated in acid resistance and pathogenesis the food borne pathogens Vibrio vulnificus cholerae.To date, full-length crystal structure of V. cholerae determined characterized by a tetrameric assembly consisting DNA binding domain regulatory (RD).Although acidic pH low oxygen tension might be involved activation AphB, it remains unknown which ligand or stimulus activates at molecular level.In this study, we determine RD from under aerobic...