A5088380641- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Aquaculture disease management and microbiota
- Genomics and Phylogenetic Studies
- Yersinia bacterium, plague, ectoparasites research
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
Seoul National University
2020-2024
Korea Research Institute of Bioscience and Biotechnology
2023
Commensal bacteria are critically involved in the establishment of tolerance against inflammatory challenges, molecular mechanisms which just being uncovered. All kingdoms life produce aminoacyl-tRNA synthetases (ARSs). Thus far, non-translational roles ARSs have largely been reported eukaryotes. Here, we report that threonyl-tRNA synthetase (AmTARS) gut-associated bacterium Akkermansia muciniphila is secreted and functions to monitor modulate immune homeostasis. Secreted AmTARS triggers M2...
Many pathogenic bacteria form biofilms to survive under environmental stresses and host immune defenses. Differential expression (DE) analysis of the genes in biofilm planktonic cells a single condition, however, has limitations identify essential for formation. Independent component (ICA), machine learning algorithm, was adopted comprehensively Vibrio vulnificus, fulminating human pathogen, this study. ICA analyzed large-scale transcriptome data V. vulnificus various conditions then...
Instead of conventional serotyping and virulence gene combination methods, methods have been developed to evaluate the pathogenic potential newly emerging pathogens. Among them, machine learning (ML)-based method using whole-genome sequencing (WGS) data are getting attention because recent advances in ML algorithms technologies. Here, we various models predict pathogenicity Shiga toxin-producing Escherichia coli (STEC) isolates their WGS data. The input dataset for was generated distinct...
A multifunctional autoprocessing repeats-in-toxin (MARTX) toxin plays an essential role in the virulence of many pathogens, including a fulminating human pathogen Vibrio vulnificus H-NS and HlyU repress derepress expression MARTX gene rtxA V. vulnificus, respectively. However, little is known about other regulatory proteins environmental signals involved regulation. In this study, we found that leucine-responsive protein (Lrp) activates by binding directly specifically to promoter, P Phased...
Biofilms provide bacteria with protection from environmental stresses and host immune defenses. The pathogenic marine bacterium Vibrio vulnificus forms biofilms colonizes niches such as oysters. cabABC operon encodes an extracellular matrix protein CabA the corresponding type I secretion system, which are essential for biofilm rugose colony development of V. vulnificus. In this study, molecular biological analyses revealed roles three transcriptional regulators BrpR, BrpT, BrpS in regulatory...
Vibrio vulnificus , a fulminating human pathogen, forms biofilms to enhance its survival in nature and pathogenicity during host infection. BrpR is the transcriptional regulator governing robust biofilm rugose colony formation V. but little known about both direct regulon of role regulation downstream genes. In this study, transcript analyses revealed that highly expressed thus strongly regulates gene stationary elevated cyclic di-GMP conditions. Transcriptome discovered genes, whose...
Many pathogenic bacteria form biofilms that are resistant to not only host immune defenses but also antibiotics, posing a need for the development of strategies control biofilms. In this study, prevent biofilm formation fulminating foodborne pathogen Vibrio vulnificus , chemical libraries were extensively screened identify small molecule inhibiting activity BrpR, transcriptional regulator genes. Accordingly, BrpR inhibitor BFstatin [N1-(2-chloro-5-fluorophenyl)-N3-propylmalonamide], with...