A5102856991- Gut microbiota and health
- Probiotics and Fermented Foods
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Higher Education Research Studies
- Education and Learning Interventions
- Virus-based gene therapy research
- Educational Systems and Policies
- Viral Infections and Immunology Research
- GDF15 and Related Biomarkers
- Helminth infection and control
- Customer Service Quality and Loyalty
- Biochemical Analysis and Sensing Techniques
- RNA modifications and cancer
- Diverse Approaches in Healthcare and Education Studies
- Innovations in Educational Methods
- Advanced Biosensing Techniques and Applications
- Animal Virus Infections Studies
- Healthcare Education and Workforce Issues
- Recreation, Leisure, Wilderness Management
- Microbial Community Ecology and Physiology
- Biochemical effects in animals
- RNA and protein synthesis mechanisms
Washington University in St. Louis
2025
Seoul National University
2016-2024
Government of the Republic of Korea
2020
University of Florida
2014
University of Minnesota
2007
Abstract Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort used for external validation. Subjects classified into three subgroups according to histological spectra or fibrosis severity. Significant alterations diversity observed severity non-obese, not obese, subjects....
Commensal bacteria are critically involved in the establishment of tolerance against inflammatory challenges, molecular mechanisms which just being uncovered. All kingdoms life produce aminoacyl-tRNA synthetases (ARSs). Thus far, non-translational roles ARSs have largely been reported eukaryotes. Here, we report that threonyl-tRNA synthetase (AmTARS) gut-associated bacterium Akkermansia muciniphila is secreted and functions to monitor modulate immune homeostasis. Secreted AmTARS triggers M2...
Weight loss and exercise intervention have been reported to increase the interaction between Bacteroides spp Akkermansiamuciniphila (Am), although underlying mechanisms consequences of remain unknown.Using a healthy Korean twin cohort (n = 582), we analyzed taxonomic associations with host body mass index. B vulgatus strains were isolated from mice human subjects investigate strain-specific effect SNUG 40005 (Bvul) on obesity. The Am enrichment by Bvul administration investigated multiple...
<italic>L. acidophilus</italic>treatment can modulate immune responses, control the micro-RNA levels and restore gut microbiota of mice with DSS-induced colitis. Therefore,<italic>L. could be useful to inflammatory bowel diseases.
Phytochemicals provide environmentally friendly and relatively inexpensive natural products, which could potentially benefit public health by controlling human norovirus (HuNoV) infection. In this study, 18 different phytochemicals were evaluated for antiviral effects against using murine (MNV) as a model biology. Among these phytochemicals, curcumin (CCM) was the most potent anti-noroviral phytochemical, followed resveratrol (RVT). cell culture infection model, exposure to CCM or RVT 3 days...
Nonalcoholic fatty liver disease (NAFLD) is associated with high carbohydrate (HC) intake. We investigated whether the relationship between intake and NAFLD mediated by interactions gut microbial modulation, impaired insulin response, hepatic de novo lipogenesis (DNL). Stool samples were collected from 204 Korean subjects biopsy-proven (n = 129) without 75). The microbiome profiles analyzed using 16S rRNA amplicon sequencing. Study grouped activity score (NAS) percentage energy dietary...
This study examined the relationship of student use campus recreation facilities (CRFs) with retention and graduation rates at a large, public, Midwestern Carnegie doctoral-extensive university. Tinto's interactionalist theory departure provided conceptual framework. An extensive review literature on between academic performance facility identified set critical explanatory predictors. Although anecdotal evidence studies perceptions support contention that CRFs promotes social integration,...
Olfactory receptors are ectopically expressed in extra-nasal tissues. The gut is constantly exposed to high levels of odorants where ectopic olfactory may play critical roles. Activation receptor 544 (Olfr544) by azelaic acid (AzA), an Olfr544 ligand, reduces adiposity mice fed a high-fat diet (HFD) regulating fuel preference fats. Herein, we investigated the novel function gut. In GLUTag cells, AzA induces cAMP-PKA-CREB signaling axis and increases secretion GLP-1, enteroendocrine hormone...
Non-alcoholic fatty liver disease (NAFLD) is closely associated with type 2 diabetes mellitus (T2D), and these two metabolic diseases demonstrate bidirectional influences. The identification of microbiome profiles that are specific to injury or impaired glucose metabolism may assist understanding the role gut microbiota in relationship between NAFLD T2D. Here, we studied a biopsy-proven Asian cohort (n = 329; 187 participants NAFLD, 101 T2D, 41 neither) identified Enterobacter, Romboutsia,...
Abstract Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe inflammation in Kupffer cells (KCs) despite the increased influx of lipopolysaccharide (LPS), suggesting presence a veiled tolerance mechanism. In addition to LPS, liver is affected by several gut-derived neurotransmitters through portal blood, effects catecholamines on KCs have not been clearly explored alcohol-associated disease (ALD). Hence, we investigated regulatory roles catecholamine...
Background Fasciola hepatica , a globally distributed helminth, causes fasciolosis, disease with significant health and economic impacts. Variability in triclabendazole (TCBZ) efficacy emerging resistance are remaining challenges. Evidence suggests that the gut microbiome influences host-helminth interactions is associated anthelmintic effects, but its association human F. infection TCBZ not well understood. Methods In this study, we investigated relationship between through metagenomic...
The cocktails of antibiotics are utilized to study the functions microbiota. There have been studies on alteration not only microbiota composition but also host's metabolism or immunity. However, bacterial species associated with these altered physiologic markers still unclear. Therefore, we supplied mice drinking water containing ampicillin (AMP), vancomycin (VAN), neomycin (NEO), metronidazole (MET) observe effect each antibiotic helper T cells and inflammation-related gene expression...
Development of more sophisticated implantable brain-machine interface (BMI) will require both interpretation the neurophysiological data being measured and subsequent determination signals to be delivered back brain. Computational models are heart machine BMI therefore an essential tool in these processes. One approach is utilize brain biomimetic (BMMs) develop instantiate algorithms. These then must connected as hybrid systems order BMM with vivo acquisition devices prosthetic devices. The...
Abstract Influenza virus infection is an important public-health concern because of its high transmissibility and potential for severe complications. To mitigate the severity complications influenza, probiotics containing Lactobacillus are used generally recognized as safe. We evaluated anti-influenza effect Limosilactobacillus reuteri ( L. ) KBL346, isolated from fecel sample healthy South Koreans, in mice. BALB/c mice were orally administered live heat-inactivated KBL346. After with...
그 동안 교육부의 각종 창업 관련 사업과 예산 확대, 대학 차원에서의 창업교육 다양화 및 활성화를 위한 노력이 이루어져 왔다. 그러나 기존의 학생 창업에 관한 연구는 대학의 특성들, 즉 기관 특성과 조직 역량 특성, 창업교육과 같은 비교과 교육과정의 과정적 특성에 효과 분석에 소홀하였다. 이러한 문제의식에 기반하여 본 창업과 관련한 특성 변인, 창업교육이라는 대학교육의 변인의 효과성을 분석함으로써 창업성과의 증대 방안을 탐색하고자 하였다. 연구의 목적을 해결하기 위해 활용한 분석 자료는 ‘에듀데이터 서비스 시스템’ 데이터와 ‘대학정보공시’ 데이터이며, 방법은 순차적 회귀분석이다. 분석결과, 학생창업자수에 영향을 미치는 변인은 규모, SCI급 논문수로 나타났고, 창업전담교원수, 창업동아리 참여인원은 학생창업자수의 차이를 만들어내는 데 기여하지 못하는 것으로 나타났다. 결과에 기초하여 대학생의 창업성과 증대를 정책적 시사점을 제공하면 다음과 같다. 첫째, 대학은 창업지원역량을...