A5100351253- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Chemokine receptors and signaling
- Allergic Rhinitis and Sensitization
- Phase Equilibria and Thermodynamics
- Cancer, Stress, Anesthesia, and Immune Response
- Astrophysics and Star Formation Studies
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Astro and Planetary Science
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
- Dermatology and Skin Diseases
Seoul National University
2017-2024
Upon encountering allergens, CD4 + T cells differentiate into IL-4-producing Th2 in lymph nodes, which later transform polyfunctional producing IL-5 and IL-13 inflamed tissues. However, the precise mechanism underlying their polyfunctionality remains elusive. In this study, we elucidate pivotal role of NRF2 murine models allergic asthma human cells. We found that an increase reactive oxygen species (ROS) immune infiltrating lungs is necessary for development eosinophilic vivo. Deletion ROS...
Liver X receptor (LXR) is a critical regulator of cholesterol homeostasis that inhibits T cell (TCR)-induced proliferation by altering intracellular sterol metabolism. However, the mechanisms which LXR regulates helper subset differentiation remain unclear. Here, we demonstrate crucial negative follicular (Tfh) cells in vivo. Both mixed bone marrow chimera and antigen-specific adoptive cotransfer studies show specific increase Tfh among LXRβ-deficient CD4 + population response to...
Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, presence of similar non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we find a negative association between psoriasis fatty acid metabolism, as well Th2 signature. Homeostatic expression liver X receptor (LXR) peroxisome proliferator-activated gamma (PPARγ) is essential maintaining metabolism conferring resistance to mice. Perturbation signal...
Ketamine is widely used in animals and humans as a systemic anesthetic. Although several immune-modulatory functions of ketamine have been reported, the effects on differentiation Th17 cell are unknown. We found that significantly diminished frequency IL-17-producers among CD4+ T cells stimulated under Th17-skewing conditions. Mechanistic studies showed had little effect production Th17-inducing cytokines by dendritic proliferation response to anti-CD3; however it hampered IL-21 expression...
<title>Abstract</title> High-mass stars, born in massive dense cores (MDCs), play a major role the cosmic ecosystem. Yet, little is known about how MDCs assemble their mass beyond ∼0.1 pc and transport into smaller denser seeds of stellar embryos (∼100 au) finally onto HighMass Young Stellar Objects (HMYSOs), which key to understand high-mass star formation processes. Leveraging multi-scale observations at 40–2500 au resolutions toward an MDC with least one HMYSO associated, we discovered...