A5101460783- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Food Quality and Safety Studies
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Fermentation and Sensory Analysis
- Allelopathy and phytotoxic interactions
- Dysphagia Assessment and Management
- Plant Physiology and Cultivation Studies
- Voice and Speech Disorders
- Soybean genetics and cultivation
- Pesticide Residue Analysis and Safety
- Lung Cancer Treatments and Mutations
- Renal Diseases and Glomerulopathies
- Seaweed-derived Bioactive Compounds
- Meta-analysis and systematic reviews
- Ferroptosis and cancer prognosis
- Dialysis and Renal Disease Management
- Immune cells in cancer
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Horticultural and Viticultural Research
- Phytochemicals and Antioxidant Activities
Korea Basic Science Institute
2010-2024
Pusan National University
2024
Sungkyunkwan University
2010-2023
Jeju National University
2023
Bucheon St. Mary's Hospital
2023
Catholic University of Korea
2023
Daegu Catholic University Medical Center
2022
Youngsan University
2013
The geographical origin of beef is increasing interest to consumers and producers due "mad cow" disease the implementation Free Trade Agreement (FTA). In this study, 1H NMR spectroscopy coupled with multivariate statistical analyses was used differentiate samples. Principal component analysis (PCA) orthogonal projection latent structure−discriminant (OPLS-DA) showed significant separation between extracts originating from four countries: Australia, Korea, New Zealand, United States. major...
Curcuma, a genus of rhizomatous herbaceous species, has been used as spice, traditional medicine, and natural dye. In this study, the metabolite profile Curcuma extracts was determined using gas chromatography-time flight mass spectrometry (GC/TOF MS) ultrahigh-performance liquid chromatography–quadrupole time-of-flight (UPLC/Q-TOF to characterize differences between aromatica longa grown on Jeju-do or Jin-do islands, South Korea. Previous studies have performed primary profiling species in...
Proton pump inhibitors (PPIs) are commonly used drugs to relieve gastrointestinal tract symptoms, but their acid-inhibitory action negatively affects the bioavailability and clinical outcomes of orally administered concomitant drugs.To identify patients with advanced breast cancer who concomitantly use PPIs palbociclib.This retrospective cohort study nationwide claims data between November 1, 2016, July 31, 2021, in South Korea. Patients receiving palbociclib 2017, 2020, were identified....
Curcuma is used to treat skin diseases and colic inflammatory disorders, in insect repellants antimicrobial antidiabetic medications. Two species (C. aromatica C. longa) grown Jeju-do Jin-do were this study. Methanolic extracts analyzed by (1)H NMR spectroscopy, metabolite profiling coupled with multivariate analysis was applied characterize the differences between or origin. PCA showed significantly greater than origins, metabolites responsible for identified. The concentrations of sugars...
Abstract Active thermogenesis in the brown adipose tissue (BAT) facilitating utilization of lipids and glucose is critical for maintaining body temperature reducing metabolic diseases, whereas inactive BAT accumulates adipocytes (BAs), leading to whitening. Although cellular crosstalk between endothelial cells (ECs) essential transport fatty acid BAs, angiocrine roles ECs mediating this remain poorly understood. Using single-nucleus RNA sequencing knock-out male mice, we demonstrate that...
TFE3-rearranged renal cell cancer (tRCC) is a rare form of RCC that involves chromosomal translocation the Xp11.2 TFE3 gene. Despite its early onset and poor prognosis, molecular mechanisms pathogenesis tRCC remain elusive. This study aimed to identify novel therapeutic targets for patients with primary recurrent tRCC. We collected 19 TFE3-positive tissues were diagnosed by immunohistochemistry subjected them genetic characterization examine their genomic transcriptomic features....
Arctium lappa L. (Asteraceae), also known as burdock, has a long history of cultivation dietary vegetable worldwide. Stress in plants disrupts metabolic homeostasis and requires adjustment pathways. Exposure to heavy metals is one the most prevalent environmental stresses encountered by plants. In this study, metabolite profiling based on 1H NMR GC–MS was used obtain holistic view response burdock roots copper stress. The principal component analysis model generated from data showed...
Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance-based metabolomic profiling and identified 26 metabolites in urine samples. collected samples from 201, 77, 47, 36 136 patients IgAN, membranous nephropathy, minimal change disease, lupus nephritis healthy controls, respectively. determined whether level associated the prognosis IgAN through Cox regression...
Excess exposure to ionizing radiation generates reactive oxygen species and increases the cellular inflammatory response by modifying various metabolic pathways. However, an investigation of perturbations organ‐specific responses based on amount during acute phase has not been conducted. In this study, high‐resolution magic‐angle‐spinning (HR‐MAS) NMR solution NMR‐based profiling were used investigate dose‐dependent changes in multiple organs tissues – including jejunum, spleen, liver,...
[Purpose] This study examined the differences in muscle activation between flat and normal feet one-leg standing position which delivers greatest load to lower extremity. [Subjects] was conducted with 23 adults, 12 feet, ages ranging from 21 30 years old, who had no neurological history or gait problems. [Methods] The leg used for one dominant of subjects. experimenter instructed subjects raise non-dominant their eyes open, maintained a posture leg's knee flexed at 90° hip joint 45° six...
Abstract Background Allergic asthma, one of the most common types is thought to be highly susceptible respiratory viral infections; however, its pathological mechanism needs elucidated. Recent studies have found impaired T-cell function in asthmatic mice. Therefore, we aimed investigate way by which asthma induction affects exhaustion lungs and assess relationship between influenza infection. Methods Chronic allergic mice were induced intranasal injection ovalbumin for 6 weeks features T...
Marine algae are photosynthetic eukaryotic organisms that widely used as sources of food, cosmetics, and drugs. However, their biological immunological effects on immune cells have not been fully elucidated. To unravel activity broaden application, we generated antigen-presenting (APCs), including dendritic (DCs) macrophages, from mouse bone marrow treated them with six different marine extracts (MAEs). We evaluated cell viability, activation marker expression, pro-inflammatory cytokine...
ABSTRACT Polybrominated diphenyl ethers (PBDEs) are commonly used to retard the combustion of materials such as foam padding, textiles, or plastics, and numerous studies have confirmed accumulation thereof in environment fish, mammals, humans. In this study, we metabolomics conduct an environmental risk assessment PBDE‐209. We profiled urinary metabolites control PBDE‐treated rats (exposed PBDE‐209) using nuclear magnetic resonance (NMR) mass spectrometry (MS). Global metabolic profiling...
Abnormal tumor cell metabolism is a consequence of alterations in signaling pathways that provide critical selective advantage to cancer cells. However, systematic characterization the metabolic and altered stem-like cells (CSCs) currently lacking. Using nuclear magnetic resonance mass spectrometry, we profiled whole-cell metabolites pair parental (P-231) (S-231), then integrated with whole transcriptome profiles. We identified elevated NAAD+ S-231 along coordinated increased expression...
Bariatric surgery alleviates obesity and ameliorates glucose tolerance. Using metabolomic proteomic profiles, we evaluated metabolic changes in serum liver tissue after duodenal-jejunal bypass (DJB) rats fed a normal chow diet. We found that the levels of vitamin B12 sera DJB rates were decreased. In rats, betaine-homocysteine S-methyltransferase decreased, whereas serine, cystathionine, cysteine, glutathione, cystathionine β-synthase, glutathione S-transferase, aldehyde dehydrogenase...
An inter-laboratory study was performed to evaluate the performance of a method developed for quantification enrofloxacin in chicken meat. Liquid-liquid extraction combined with clean-up procedure based on solid-phase followed by liquid chromatography-tandem mass spectrometric used three individual laboratories. All investigated results calibration curves and limits were within acceptable range regulatory testing enrofloxacin. The laboratories received blind certified reference material...
The ability to maintain systemic metabolic homeostasis through various mechanisms represents a crucial strength of kidneys in the study syndrome or aging. Moreover, age-associated kidney failure has been widely accepted. However, efforts demonstrate aging-dependent renal rewiring have limited. In present study, we investigated aging-related determinants by integrating metabolomic and transcriptomic data sets from young (3 months,
The voice has been thought to be associated with emotions, but conducting large-scale research on this relationship some limitations. To overcome these limitations, questionnaires have utilized as a tool.A population-based cross-sectional study was done. A total of 15,977 participants completed regarding self-recognition disorder (SRVD), and mental health status.1053(6.6 %) answered that they had SRVD. In the multivariate Cox proportional hazard model, psychological stress (Hazard ratio (HR)...
Introduction Rheumatoid arthritis (RA) generally requires lifelong treatment; however, its medication complexity might affect non-adherence. Pharmacist-led telehealth services were as effective face-to-face and reduced potential side effects in outpatients with chronic diseases. This study aims to analyse the effect of a telepharmacy service customised mobile device comparison usual pharmacist on humanistic clinical outcomes patients RA. Methods analysis The is designed prospective,...
Recent studies show that shifts in energy metabolism activated microglia are linked to their functions and immune responses the ischemic brain. We previously reported an antagonist of bone morphogenetic protein, noggin, enhanced myelination brain during chronic phase, conditioned media (CM) from BV2 treated with noggin after ischemia/reperfusion (I/R) increased expression myelin basic protein (MBP) oligodendrocytes (MO3.13). To determine whether induced changes cell metabolism, metabolite...