A5077005137- Head and Neck Cancer Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Voice and Speech Disorders
- Neuroscience and Neuropharmacology Research
- Dysphagia Assessment and Management
- Cancer-related molecular mechanisms research
- Tracheal and airway disorders
- Medicinal Plants and Neuroprotection
- Tryptophan and brain disorders
- Esophageal and GI Pathology
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Microbial Natural Products and Biosynthesis
- Esophageal Cancer Research and Treatment
- Speech Recognition and Synthesis
- Plant and fungal interactions
- Single-cell and spatial transcriptomics
- Curcumin's Biomedical Applications
- Cervical Cancer and HPV Research
- Cerebral Venous Sinus Thrombosis
- Liver Disease Diagnosis and Treatment
- Menopause: Health Impacts and Treatments
- Genomics and Phylogenetic Studies
Catholic University of Korea
2015-2025
Kyung Hee University East-West Neo Medical Center
2015-2024
Yeouido St. Mary's Hospital
2022-2023
St. Paul's Hospital
2023
Translational Therapeutics (United States)
2021-2023
University of Pennsylvania
2017-2023
Seoul St. Mary's Hospital
2022
Bucheon St. Mary's Hospital
2020-2022
Pohang University of Science and Technology
2022
Soongsil University
2021
Background: Descriptive epidemiologists have repeatedly reported that males are more susceptible to head and neck cancers. However, most published data those of cross-sectional studies, no population-based cohort study has yet been published. The aim this was compare the prevalence cancers in healthy with females. Methods: A retrospective using Korean National Health Insurance Service database on 9,598,085 individuals who underwent regular health checkups from 1 January 31 December 2009. We...
Voice changes may be the earliest signs in laryngeal cancer. We investigated whether automated voice signal analysis can used to distinguish patients with cancer from healthy subjects. extracted features using software package for speech phonetics (PRAAT) and calculated Mel-frequency cepstral coefficients (MFCCs) samples of a vowel sound /a:/. The proposed method was tested six algorithms: support vector machine (SVM), extreme gradient boosting (XGBoost), light boosted (LGBM), artificial...
Intravenous administration of mesenchymal stem cells (MSCs) has served as a clinical intervention for inflammatory diseases. Once entered to blood circulation, MSCs are exposed harsh environment which sharply decreases cell viability due the fact that injected cells, being susceptible shear stress, subjected high velocities bloodstream and lack proper mechanical support keeping them in an attachment-deprived state. Here, we coated nanofilm onto viable by depositing poly-l-lysine hyaluronic...
Seok Lee, Hyun-Bum Kim, Eun-Sang Hwang, Eun-seok Sung-Soo Tae-Dong Jeon, Min-cheol Song, Ji-Seung Min-Chan Chung, Sungho Maeng and Ji-Ho Park. Exp Neurobiol 2018;27:189-99. https://doi.org/10.5607/en.2018.27.3.189
Curcumin is a major diarylheptanoid component of Curcuma longa with traditional usage for anxiety and depression. It has been known the anti-inflammatory, antistress, neurotropic effects. Here we examined curcumin effect in neural plasticity cell viability. 60-channel multielectrode array was applied on organotypic hippocampal slice cultures (OHSCs) to monitor 10 μ M long-term depression (LTD) through low-frequency stimulation (LFS) Schaffer collaterals commissural pathways. Cell viability...
Abstract Background Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of brain dysfunction. Methylglyoxal (MGO) formation, which is heightened in diabetes owing to hyperglycemia gut dysbiosis, may serve as a critical link between diseases. Despite the high prevalence MGO, precise mechanisms underlying MGO-induced depression remain unclear. Results We investigated effect MGO stress on like-behavior elucidate potential...
Introduction. Mucosal margins exhibit a mean shrinkage of 30–40% after resection oral and oropharyngeal cancers, an adequate in situ surgical margin frequently results pathological close margin. However, the impact on prognosis remains unclear. We investigated disease-free survival (DFS) overall (OS). Methods. retrospectively reviewed clinicopathological data 418 patients diagnosed with squamous cell carcinomas cavity or oropharynx who underwent initial surgery (with curative intent) at our...
Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by memory loss and cognitive decline. Among the suggested pathogenic mechanisms of AD, cholinergic hypothesis proposes that AD symptoms are result reduced synthesis acetylcholine (ACh). A non-selective antagonist muscarinic ACh receptor, scopolamine (SCOP) induced impairment in rodents. Umbelliferone (UMB) Apiaceae-family-derived 7-hydeoxycoumarin known for its antioxidant, anti-tumor, anticancer, anti-inflammatory,...
The treatment of laryngeal cancer requires clinical decision-making that balances survival outcomes with the preservation essential functions such as voice and swallowing. study, led by Clinical Practice Guideline Committee Korean Society Head Neck Surgery, aims to establish evidence-based recommendations guide optimal decisions for patients from surgeons' perspectives. A literature search was conducted in PubMed, Embase, Cochrane Library, KoreaMed databases a expert reviewed panel 39...
Abstract Voice change is often the first sign of laryngeal cancer, leading to diagnosis through hospital laryngoscopy. Screening for cancer solely based on voice could enhance early detection. However, identifying indicators specific challenging, especially when differentiating it from other ailments. This study presents an artificial intelligence model designed distinguish between healthy voices, and those conditions. We gathered samples individuals with vocal cord paralysis, benign mucosal...
Ethanol (EtOH) abuse induces significant mortality and morbidity worldwide because of detrimental effects on brain function. Defining the contribution astrocytes to this malfunction is imperative understanding overall EtOH due their role in homeostasis EtOH-seeking behaviors. Using a highly controllable vitro system, we identify chemical signaling mechanisms through which acute exposure modulatory feedback loop between neurons astrocytes. Neuronally-derived purinergic primed subpopulation...
Background Whether dynamic changes of metabolic syndrome (MetS) affects the subsequent laryngeal cancer occurrence remains unknown. Objective This study investigated effects MetS on incidence due to a lack knowledge regarding development in Korean population. Methods A total 6,757,048 individuals who received national health checkup 2009 and follow-up examination 2011 were analyzed followed up until 2018. status included following categories: MetS-chronic (n = 941,609), MetS-developed...
Abstract Abnormal voice may identify those at risk of post-stroke aspiration. This study was aimed to determine whether machine learning algorithms with recorded via a mobile device can accurately classify dysphagia tube feeding and aspiration pneumonia be used as digital biomarkers. Voice samples from patients referred for swallowing disturbance in university-affiliated hospital were collected prospectively using device. Subjects that required further classified high respiratory...
Astrocytes play a critical role in brain function, but their contribution during ethanol (EtOH) consumption remains largely understudied. In light of recent findings on the heterogeneity astrocyte physiology and gene expression, an approach with ability to identify subtypes capture this is necessary. Here, we combined measurements calcium signaling expression define EtOH-induced subtypes. absence demonstrated EtOH receptor, believed have effects function many receptors downstream biological...
ABSTRACT It was previously proposed that regio-specific hydroxylation of an immunosuppressive cyclosporine (CsA) at the 4th N -methyl leucine is mediated by cytochrome P450 hydroxylase (CYP) in rare actinomycete Sebekia benihana . This modification thought to be reason for hair growth-promoting side effect without activity CsA. Through S. genome sequencing and silico analysis, we identified complete complement (CYPome) , including 21 CYPs their electron transfer partners, consisting 7...
Artemisia princeps (AP) is a flowering perennial used as traditional medicine and dietary supplement across East Asia. No study has yet assessed its effects on synaptic plasticity in hippocampus much less model of ovarian hormone deficiency. We examined the influence chronic oral AP ethanol extract treatment ovariectomized rats induction long-term depression representative synapse (CA3-CA1) hippocampus. Ovariectomized demonstrated lower trabecular mean bone mineral densities than sham,...
ESP‐102, an extract from Angelica gigas, Saururus chinensis , and Schisandra has been used as herbal medicine dietary supplement in Korea. Despite the numerous bioactivities vitro vivo studies, its effects on neuronal networks remain elusive. To address effect, we examined synaptic plasticity organotypic hippocampal slice culture with multielectrode array. Our results showed increase excitatory postsynaptic potential (EPSP), indicating induction of long‐term potentiation (LTP), presence...