A5100687450- Advanced Glycation End Products research
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Alcohol Consumption and Health Effects
- Cynara cardunculus studies
- Phytochemistry and Bioactive Compounds
- Sensorless Control of Electric Motors
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Liver physiology and pathology
- Nanoplatforms for cancer theranostics
- Protein Kinase Regulation and GTPase Signaling
- Electric Motor Design and Analysis
- Dermatology and Skin Diseases
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- IL-33, ST2, and ILC Pathways
Gachon University
2016-2024
Chonnam National University Hwasun Hospital
2015-2020
Southern California Institute of Architecture
2016
Engineering Arts (United States)
2016
Sungkyunkwan University
2011-2015
Chonnam National University Hospital
2010-2015
Kangbuk Samsung Hospital
2015
Agruicultural Research Institute
2014
Springer Nature (Germany)
2014
Exelixis (United States)
2006-2013
Sulforaphane (SFN), a potent nuclear factor erythroid 2-related 2 (Nrf2) activator, is present in the species of Brassicaceae, especially broccoli sprouts. In this study, effects SFN against microglial activation and inflammation, potential mechanisms involved, were analyzed. As mitogen-activated protein kinase (MAPK) signaling plays key role we focused on regulating MAPK regulation inflammatory anti-inflammatory cascades lipopolysaccharide (LPS)-activated microglia. The immunomodulatory...
Oncogenic BRAF alleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibition of the activated mutant protein kinase may reverse tumor phenotype. Here, we report characterization SB-590885, a novel triarylimidazole selectively inhibits Raf kinases with more potency towards B-Raf than c-Raf. Crystallographic analysis revealed SB-590885 stabilizes oncogenic domain in an active configuration, which is distinct from previously reported mechanism action...
Oxidative stress during sepsis pathogenesis remains the most-important factor creating imbalance and dysregulation in immune-cell function, usually observed following initial infection. Hydrogen peroxide (H2O2), a potentially toxic reactive oxygen species (ROS), is excessively produced by pro-inflammatory immune cells phases of plays dominant role regulating pathways associated with systemic inflammatory activation. In present study, we constructed scavenger mannosylated polymeric albumin...
Abstract Methylglyoxal (MGO)-induced cellular apoptosis, oxidative stress, inflammation, and AGE formation are specific events that induce vascular endothelial cell (EC) toxicity in dysfunction (ED). MGO accumulates quickly various tissues plays a prominent role the pathogeneses of several diabetic complications. Unbalanced angiogenesis is gateway to development EC apoptosis autophagy work together regulate by interacting with different angiogenic factors. In addition understanding deep...
The aim of this study was to investigate the effects paeoniflorin (PF) and paeonol (PN), main active compounds Paeonia albiflora Pallas, on myocardial ischemia reperfusion (I/R)-induced injury in Sprague-Dawley rats vivo. Under anesthesia, were subjected 25 min by ligation left anterior descending coronary artery (LAD) followed 6 h (Western blot analysis) or 24 (hemodynamics infarct size) reperfusion. When size measured as percentage area at risk, both PF (25.0 % ± 7.0 %) PN (24.1 5.5...
A series of novel, highly potent, selective, and ATP-competitive mammalian target rapamycin (mTOR) inhibitors based on a benzoxazepine scaffold have been identified. Lead optimization resulted in the discovery with low nanomolar activity greater than 1000-fold selectivity over closely related PI3K kinases. Compound 28 (XL388) inhibited cellular phosphorylation mTOR complex 1 (p-p70S6K, pS6, p-4E-BP1) 2 (pAKT (S473)) substrates. Furthermore, this compound displayed good pharmacokinetics oral...
Abstract Background Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of brain dysfunction. Methylglyoxal (MGO) formation, which is heightened in diabetes owing to hyperglycemia gut dysbiosis, may serve as a critical link between diseases. Despite the high prevalence MGO, precise mechanisms underlying MGO-induced depression remain unclear. Results We investigated effect MGO stress on like-behavior elucidate potential...
Advanced hepatic fibrosis therapy using drug-delivering nanoparticles is a relatively unexplored area. Angiotensin type 1 (AT1) receptor blockers such as losartan can be delivered to stellate cells (HSC), blocking their activation and thereby reducing progression in the liver. In our study, we analyzed possibility of utilizing drug-loaded vehicles hyaluronic acid (HA) micelles carrying attenuate HSC activation. Losartan, which exhibits inherent lipophilicity, was loaded into hydrophobic core...
Resveratrol-enriched rice (RR) was developed using genetic engineering to combine the properties of resveratrol and rice. To evaluate effect RR on pruritic skin inflammation in atopic dermatitis (AD)-like lesions, we used dinitrochlorobenzene (DNCB)-induced NC/Nga mice an vitro 3D model. Normal (NR), resveratrol, were topically applied dorsal skin, following which index scratching frequency calculated. Histological examination performed by hematoxylin eosin immunohistochemistry staining...
Isorhapontigenin (ISO), a tetrahydroxylated stilbenoid, is an analog of resveratrol (Rsv). The various biological activities Rsv and its derivatives have been previously reported in the context both cancer inflammation. However, anti-cancer effect ISO against breast has not well established, despite being orally bioavailable dietary polyphenol. In this study, we determine effects using MCF7, T47D, MDA-MB-231 cell lines. We observed that induces death, cycle arrest, oxidative stress,...
Advanced glycation end products (AGEs) are produced through the binding of glycated protein or lipid with sugar, and they known to be involved in pathogenesis both age-dependent independent neurological complications. Among dicarbonyl compounds, methylglyoxal (MGO), which is from glucose breakdown, a key precursor AGE formation neurotoxicity. Several studies have shown toxic effects bovine serum albumin (BSA)-AGE (prepared glucose, sucrose fructose) vitro vivo. In fact, MGO-derived AGEs...
Lespedeza cuneata G.Don (LCE), which belongs to the genus (Leguminosae), is a traditional oriental medicine known prevent diabetes and cardiovascular diseases. However, no scientific studies about effectiveness of LCE, their responsible bioactive constituents, its mechanisms against endothelial dysfunction have been performed.This study was performed investigate role LCE chemical components in ameliorating dysfunction.The production nitric oxide (NO) evaluated after treatment HUVECs. Cell...
Lespedeza bicolor (LB) is often used in traditional medicine to remove toxins, replenish energy stores, and regulate various symptoms of diabetes. This study aimed explore the use LB as a therapeutic prevent diabetic nephropathy methylglyoxal (MGO)-treated models vitro vivo. Western blotting, immunostaining, biochemical assays were obtain several experimental readouts renal epithelial cells (LLC-PK1) BALB/c mice. These include: production reactive oxygen species (ROS), formation advanced...
Methylglyoxal (MGO) is a highly reactive metabolite of glucose. Elevated levels MGO induce the generation oxygen species (ROS) and cause cell death in endothelial cells. Vascular damage by ROS has been implicated progression diabetic vascular complications, cardiovascular diseases, atherosclerosis. In this study, protective effect isosamidin, isolated from Peucedanum japonicum roots, on MGO-induced apoptosis was investigated using human umbilical vein cells (HUVECs). Among 20 compounds P....
Methylglyoxal (MGO) is a highly reactive dicarbonyl compound that causes endothelial dysfunction and plays important roles in the development of diabetic complications. Peanuts are rich energy, minerals, antioxidants. Here, we report potential beneficial effects peanuts, particularly phenolic contents, against MGO-mediated cytotoxicity. Firstly, optimized extraction conditions for maximum yield phenolics from peanuts by examining different processing methods solvents. To estimate contents...
Pyrus ussuriensis Maxim. has been reported to treat the fever, cough, asthma, and chronic skin disease in Korean Medicine. However, there is no scientific evidence for use of Leaves (PUL) extract or its mechanism action atopic dermatitis (AD). This study was performed find potential therapeutic effects PUL on progression AD using vitro vivo experimental models.We examined production nitric oxide (NO) RAW 264.7, Interleukin 6 (IL-6) 1β (IL-1β) tumor necrosis factor α (TNF-α) -induced HaCaT...
Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation sylvestre led to isolation five new pregnane glycosides, gymsylosides A–E (1–5) and four known oleanane saponins, 3β-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3β-O-β-D-xylopyranosyl-(1→6)-β-D- glucopyranosyl-(1→6)-β-D-glucopyranosyl (8), alternoside XIX (9). Their...
This paper proposes the field weakening method of IPMSM(Interior Permanent Magnet Synchronous Machine) for electric vehicle (EV) application. The using lookup-table generally used in automotive application has merits fast dynamics, however containable data is limited especially on DC-link voltage. On other hands, a voltage feedback control advantages current at variable speed and automatically. However, dynamics determined by gain controller. In this paper, achieved suitable combination...