A5026361494- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Bone and Joint Diseases
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Gout, Hyperuricemia, Uric Acid
- Graphene and Nanomaterials Applications
- Electrochemical sensors and biosensors
- Click Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Nanoparticles: synthesis and applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Antimicrobial agents and applications
- Trace Elements in Health
- Polymer Surface Interaction Studies
University of Warwick
2022-2025
Chonnam National University
2017-2023
Bio-Medical Science (South Korea)
2022
Tufts University
2022
Oxidative stress during sepsis pathogenesis remains the most-important factor creating imbalance and dysregulation in immune-cell function, usually observed following initial infection. Hydrogen peroxide (H2O2), a potentially toxic reactive oxygen species (ROS), is excessively produced by pro-inflammatory immune cells phases of plays dominant role regulating pathways associated with systemic inflammatory activation. In present study, we constructed scavenger mannosylated polymeric albumin...
Combined cancer immunotherapy has demonstrated promising potential with an amplified antitumor response and immunosuppressive tumor microenvironment (TME) modulation. However, one of the main issues that cause treatment failure is poor diffusion insufficient penetration therapeutic immunomodulatory agents in solid tumors. Herein, a approach combines photothermal therapy (PTT) nitric oxide (NO) gas for extracellular matrix (ECM) degradation, along NLG919, indoleamine 2,3-dioxygenase (IDO)...
Excessive inflammatory response during sepsis causes irreversible damage to healthy tissues and results in multi-organ failure. During infection, bacterial endotoxin-triggered responses macrophages facilitate the recruitment of circulating leukocytes, including neutrophils monocytes. A key component that aggravates systemic is generation stable reactive oxygen species such as hydrogen peroxide (H2O2). In this study, we present a versatile strategy reduce activation tissue-resident prevent...
The deposition of monosodium urate (MSU) crystals induces the overexpression reactive oxygen species (ROS) and proinflammatory cytokines in residential macrophages, further promoting infiltration inflammatory leukocytes joints gouty arthritis. Herein, a peroxidase-mimicking nanoscavenger was developed by forming manganese dioxide over albumin nanoparticles loaded with an anti-inflammatory drug, indomethacin (BIM), to block secretion ROS COX2-induced MSU-induced arthritis model. In mouse...
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders interaction between tumor cells therefore limits applications PEGylated for therapeutic drug delivery. overcome this limitation, zwitterionic materials can be used to enhance systemic tumor-specific delivery hydrophobic agents such as IR-780 iodide dye photothermal therapy. Herein, we developed micellar using...
Triple-negative breast cancer (TNBC) features immunologically "cold" tumor microenvironments with limited cytotoxic T lymphocyte (CTL) infiltration. Although ablation therapies have demonstrated modulation of TNBC tumors to inflamed "hot" tumors, recruitment myeloid derived suppressor cells (MDSCs) at the post prevents infiltration CTLs and challenge antitumor potentials T-cell therapies. Here, a thermal immunotherapy strategy is developed prevent immune suppressive effects MDSCs during...
Human papilloma virus (HPV), one of the most common cancer-causing viruses, accounts for more than 90% human anal and cervical cancers. Clinical studies have focused on adjuvant therapy with vaccines to improve therapeutic outcomes in patients late-stage HPV-related In present study, a mannose receptor (CD206) targeting lithocholic acid-modified polyethylenimine (PEI) nano-adjuvant delivering toll-like 7/8 agonist, resiquimod (R848) (mLAPMi-R848), HPV E6- E7-expressing TC-1 tumor murine...
Antimicrobial-resistant pathogens have reached alarming levels, becoming one of the most pressing global health issues. Hence, new treatments are necessary for fight against antimicrobial resistance. Synthetic nanoengineered polymers (SNAPs) emerged as a promising alternative to peptides, overcoming some their limitations while keeping key features. Herein, library amphiphilic oxazoline-based SNAPs using cationic ring-opening polymerization (CROP) is designed. Amphipathic compounds with 70%...
Antimicrobial polymers, which have emerged as a promising alternative to antibiotics in the fight against antimicrobial resistance, are based on design of cationic host defence peptides (CHDPs). Being part mammalian innate immune system, CHDPs possess both and immunoregulatory effects manage bacterial infections. However, immunomodulatory polymers remain largely unexplored. Within this work, library 15 copolymers were synthesised by reversible addition-fragmentation chain transfer (RAFT)...
Tailoring combinatorial therapies along with real-time monitoring strategies has been the major focus of overcoming multidrug resistance in cancer. However, attempting to develop a multifunctional nanoplatform single construct leads compromising therapeutic outcomes. Herein, we developed simple, theranostic nanoassembly containing hyaluronic acid-stabilized redox-sensitive (HART) polyethylenimine polyplex composed doxorubicin (DOX) intercalated Bcl-2 shRNA encoded plasmid green-synthesized...
Malignant melanoma is a highly aggressive type of cancer that requires radical treatment strategies to inhibit the cell progression and metastasis. In recent years, preclinical research clinical trials on have been considerably focused adjuvant-based immunotherapy for enhancing immune response innate cells against cells. However, outcome these treatments inadequate due an improper delivery system activators reach target site. Hence, we developed vaccine formulation containing tumor lysate...
Gouty arthritis is characterized by chronic deposition of monosodium urate (MSU) crystals in the joints and other tissues, resulting production excess reactive oxygen species (ROS) proinflammatory cytokines that intensify synovial inflammation. This condition mainly associated with inflammatory M1 macrophage activation oxidative stress production. Hence, gout symptoms can often be resolved eliminating scavenging inflamed areas. Herein, we developed M1-macrophage-targeting biomineralized...
Malignant melanoma is a highly aggressive type of cancer that requires radical treatment strategies to inhibit the cell progression and metastasis. In recent years, preclinical research clinical trials on are considerably focused adjuvant-based immunotherapy for enhancing immune response innate cells against cells. However, outcome these treatments inadequate due improper delivery system activators reach target site. Hence, we developed vaccine formulation containing tumor lysate protein...
Combined cancer immunotherapy has demonstrated promising potential with an amplified antitumor response and immunosuppressive tumor microenvironment (TME) modulation. However, one of the main issues that cause treatment failure is poor diffusion insufficient penetration therapeutic immunomodulatory agents in solid tumors. Herein, a approach combines photothermal therapy (PTT) nitric oxide (NO) gas for extracellular matrix (ECM) degradation, along NLG919, indoleamine 2,3-dioxygenase (IDO)...