A5058562151- Bacterial biofilms and quorum sensing
- Cystic Fibrosis Research Advances
- Evolutionary Game Theory and Cooperation
- Evolution and Genetic Dynamics
- Antibiotic Resistance in Bacteria
- Bacterial Genetics and Biotechnology
- Yersinia bacterium, plague, ectoparasites research
- Vibrio bacteria research studies
- Plant and animal studies
- Inhalation and Respiratory Drug Delivery
- Gut microbiota and health
- Essential Oils and Antimicrobial Activity
- Evolutionary Psychology and Human Behavior
- Antimicrobial Peptides and Activities
- Antimicrobial Resistance in Staphylococcus
- Bee Products Chemical Analysis
- Environmental Toxicology and Ecotoxicology
- Antimicrobial agents and applications
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Animal Behavior and Reproduction
- Molecular Communication and Nanonetworks
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nosocomial Infections in ICU
University of Warwick
2016-2025
Coventry University
2016-2021
University of Nottingham
2012-2019
Université Paris 1 Panthéon-Sorbonne
2019
University of Pennsylvania
2019
Stony Brook University
2019
State University of New York
2019
Stony Brook School
2019
University of Exeter
2019
Freie Universität Berlin
2019
Summary 1. Meta‐analysis is a powerful and informative tool for basic applied research. It provides statistical framework synthesizing comparing the results of studies which have all tested particular hypothesis. has potential to be particularly useful ecologists evolutionary biologists, as individual experiments often rely on small sample sizes due constraints time manpower, therefore low power. 2. The rewards conducting meta‐analysis can significant. basis systematic review topic that...
There has been extensive theoretical debate over whether population viscosity (limited dispersal) can favour cooperation. While limited dispersal increases the probability of interactions occurring between relatives, which cooperation, it also lead to an increase in competition relatives and this reduce or completely negate selection for Despite much attention, there is a lack empirical research investigating these issues. We cultured Pseudomonas aeruginosa bacteria medium with different...
Efficient host exploitation by parasites is frequently likely to depend on cooperative behaviour. Under these conditions, mixed-strain infections are predicted show lower virulence (host mortality) than single-clone infections, due competition favouring non-contributing social 'cheats' whose presence will reduce within-host growth. We tested this hypothesis using the production of iron-scavenging siderophores pathogenic bacterium Pseudomonas aeruginosa in an insect host. found that infection...
Abstract The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which Pseudomonas aeruginosa is capable of sustaining chronic infections, are highly resistant to multiple antibiotics. Here, we investigate the phenotypic and genotypic diversity 44 morphologically identical P. isolates taken from single CF patient sputum sample. Comprehensive analysis revealed large variances trade-offs growth, virulence factors quorum sensing (QS) signals. Whole genome 22 high levels...
We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron were characterized by NMR, ESI-MS, elemental analysis, X-ray crystallography. Several of these exhibit potent activity against Gram-negative bacteria Gram-positive (including methicillin-resistant Staphylococcus aureus (MRSA)) high antifungal potency toward C. albicans neoformans, with minimum inhibitory concentrations...
Plant-derived compounds and other natural substances are a rich potential source of that kill or attenuate pathogens resistant to current antibiotics. Medieval societies used range these treat conditions clearly recognizable the modern eye as microbial infections, there has been much debate over likely efficacy treatments. Our interdisciplinary team, comprising researchers from both sciences humanities, identified reconstructed remedy for Staphylococcus aureus infection 10th century...
ABSTRACT Research into chronic infection by bacterial pathogens, such as Pseudomonas aeruginosa , uses various in vitro and live host models. While these have increased our understanding of pathogen growth, virulence, evolution, each model has certain limitations. In models cannot recapitulate the complex spatial structure organs, while experiments on hosts are limited terms sample size duration for ethical reasons; mammal also require specialized facilities which costly to run. To address...
biofilm infections in the cystic fibrosis (CF) lung are highly resistant to current antimicrobial treatments and associated with increased mortality rates. The existing models for such not able reliably mimic clinical biofilms observed. We aimed further optimise an
Bacteria produce a wide variety of exoproducts that favourably modify their environment and increase fitness. These are often termed 'public goods' because they costly for individuals to can be exploited by non-producers (cheats). The outcome conflict over public goods is dependent upon the prevailing phenotype in competition. Many bacterial species use quorum sensing (QS) signalling molecules regulate production goods. QS, therefore, determines cooperative individuals, influences In...
Biparental care of offspring is a widespread social behavior, and various ecological, life-history, demographic factors have been proposed to explain its evolution maintenance. Raising generally requires several types (e.g., feeding, brooding, defense), males females often specialize in providing different care. However, theoretical models assume that single variable hence unit by the mother interchangeable with father. We hypothesize ability one parent provide all may be limited nonadditive...
A recent workshop titled "Developing Models to Study Polymicrobial Infections," sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored development of new models study polymicrobial infections associated with airways persons cystic fibrosis (CF). The gathered 35+ investigators over two virtual sessions. Here, we present findings this workshop, summarize some challenges involved developing such models, and suggest three frameworks tackle complex problem. proposed here, believe,...
Activity tests for synthetic antimicrobial compounds are often limited to the minimal inhibitory concentration assay using standard media and bacterial strains. In this study, a family of acrylamide copolymers that act as mimics peptides were synthesized shown have disruptive effect on membranes structural integrity through microscopy techniques membrane polarization experiments. The polymers tested their properties mimic clinically relevant conditions. Additionally, activity was compared in...
The synthesis of a polysaccharide from simpler carbohydrates both by the agency Bacillus mesentericus Trevisan and subtilis Cohn has been studied. action is apparently specific in that they only bring about formation containing terminal fructo-furanose residue their molecule. A similar can be carried out using corresponding enzyme preparation mesentericus.
Social networks – diagrams which reflect the social structure of animal groups are increasingly viewed as useful tools in behavioural ecology and evolutionary biology. Network may be especially relevant to study cooperation, because action mechanisms affect cost:benefit ratio cooperating (e.g. reciprocity, punishment, image scoring) is likely mediated by relative position actor recipient network. proximity could thus cooperation a similar manner biological relatedness. To test this...
A key aim in microbiology is to determine the genetic and phenotypic bases of bacterial virulence, persistence antimicrobial resistance chronic biofilm infections. This requires tractable, high-throughput models that reflect physical chemical environment encountered specific infection contexts. Such will increase predictive power microbiological experiments provide platforms for enhanced testing novel antibacterial or antivirulence therapies. We present an optimized ex vivo model cystic...
Growth environment greatly alters many facets of pathogen physiology, including pathogenesis and antimicrobial tolerance. The importance host-mimicking environments for attaining an accurate picture behaviour is widely recognised. Whilst this recognition has translated into the extensive development artificial cystic fibrosis (CF) sputum medium, attempts to mimic growth in other respiratory disease states have been completely neglected. composition airway surface liquid (ASL) different...