A5088002858- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Porphyrin and Phthalocyanine Chemistry
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Photodynamic Therapy Research Studies
- Carbon dioxide utilization in catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Synthesis and Properties of Aromatic Compounds
- Nosocomial Infections in ICU
- Photochromic and Fluorescence Chemistry
- Bacterial biofilms and quorum sensing
- Catalytic C–H Functionalization Methods
- Antimicrobial Resistance in Staphylococcus
- Nanoplatforms for cancer theranostics
- Synthesis and biological activity
- Analytical Chemistry and Sensors
- Asymmetric Hydrogenation and Catalysis
- Legionella and Acanthamoeba research
- Nanomaterials for catalytic reactions
- Synthesis and Biological Evaluation
- Luminescence and Fluorescent Materials
- Ferrocene Chemistry and Applications
- Fluorine in Organic Chemistry
Jiangsu University
2022-2024
University of Warwick
2018-2022
First Affiliated Hospital of Gannan Medical University
2022
Coventry (United Kingdom)
2018-2020
There is a dire need for new compounds to combat antibiotic resistance: metal complexes might provide the solution. 906 were evaluated against dangerous ESKAPE pathogens and found have higher hit-rate than organic molecules.
We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron were characterized by NMR, ESI-MS, elemental analysis, X-ray crystallography. Several of these exhibit potent activity against Gram-negative bacteria Gram-positive (including methicillin-resistant Staphylococcus aureus (MRSA)) high antifungal potency toward C. albicans neoformans, with minimum inhibitory concentrations...
Half-sandwich Rh<sup>III</sup> anticancer complexes with activated Cp* rings not only undergo sequential CH<sub>3</sub> H–D exchange, but also react biological dienes, generating Rh<sup>I</sup> Diels–Alder adducts in aqueous media at ambient temperature.
Organo-ruthenium complexes catalyse formate reduction of NAD<sup>+</sup>, and enhances their antiproliferative activity in cancer cells.
There is a dire need for new classes of antimicrobial compounds to combat the growing threat widespread antibiotic resistance. With currently very scarce drug pipeline, consisting mostly derivatives known antibiotics, antibiotics are urgently required. Antibiotic notorious not having “drug-like” chemical structures. Metal complexes in clinical development treatment cancer, malaria and neurodegenerative diseases. However, only little attention has been paid their application as potential...
Sulfonyl ethylenediamine Ru( ii ) arene transfer hydrogenation catalysts can have high anticancer activity, but react rapidly with thiols, forming bridged dinuclear complexes.
Novel hybrid porphyrin(2.1.2.1)s and their boron copper complexes were synthesized using the "toy bricks" synthetic method. Crystal data, frontier molecular orbital calculations, electrostatic potential surface maps reveal that hybridization in porphyrin(2.1.2.1) donor–acceptor unit controls selective coordination of BF2.
Four structurally bent porphyrin(2.1.2.1) Pt(II) complexes have been obtained and verified well. Main absorbance of displayed a significant red-shift compared to that porphyrin(1.1.1.1) molecules. 1O2 study indicated electron-withdrawing group intramolecular charge transfer effect synergistically endowed with good singlet oxygen-sensitizing capacity under blue LED light irradiation. This work presents simple synthesis way develop new series efficient porphyrinoid oxygen photosensitizers for...
This research aimed to investigate the microbial spectrum of microorganisms that cause ventilator-associated pneumonia (VAP) among ICU patients in selected hospital, antimicrobial susceptibility, genetic diversity common isolates, and monitoring effect culture on cleaning sanitizing external ventilator circuits order reduce occurrence hospital infections. For this purpose, endotracheal aspirate (ETA) specimens were sampled from with clinically suspected VAP between August 2020 2021 then...
There is a dire need for new classes of antimicrobial compounds to combat the growing threat widespread antibiotic resistance. With currently very scarce drug pipeline, consisting mostly derivatives known antibiotics, antibiotics are urgently required. Antibiotic notorious not having “drug-like” chemical structures. Metal complexes in clinical development treatment cancer, malaria and neurodegenerative diseases. However, only little attention has been paid their application as potential...
There is a dire need for new classes of antimicrobial compounds to combat the growing threat widespread antibiotic resistance. With currently very scarce drug pipeline, consisting mostly derivatives known antibiotics, antibiotics are urgently required. Antibiotic notorious not having “drug-like” chemical structures. Metal complexes in clinical development treatment cancer, malaria and neurodegenerative diseases. However, only little attention has been paid their application as potential...