A5052144587- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- Synthesis and biological activity
- Cyclopropane Reaction Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Click Chemistry and Applications
- Fluorine in Organic Chemistry
- Oxidative Organic Chemistry Reactions
- Synthesis and Properties of Aromatic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Microbial Natural Products and Biosynthesis
- Crystallization and Solubility Studies
- Catalytic Alkyne Reactions
- X-ray Diffraction in Crystallography
- Chemical synthesis and alkaloids
- Synthesis and Catalytic Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reactions and Mechanisms
- Metal complexes synthesis and properties
- Axial and Atropisomeric Chirality Synthesis
- Chemical Reaction Mechanisms
Karlsruhe Institute of Technology
2013-2025
Karlsruhe University of Education
2020
Minia University
2011-2016
St Petersburg University
2011-2015
University of Kaiserslautern
2014
Queensland University of Technology
2014
John Innes Centre
2012
Bayer (Germany)
2008-2012
The University of Queensland
2012
University of Freiburg
2011
There is a dire need for new compounds to combat antibiotic resistance: metal complexes might provide the solution. 906 were evaluated against dangerous ESKAPE pathogens and found have higher hit-rate than organic molecules.
The current study has yielded promising results in the evaluation of a new ciprofloxacin-chalcone hybrid (CP derivative) for its anticancer activity as potential Topoisomerases (Topo) I and II inhibitors. vitro showed that CP derivative significantly suppressed growth HCT-116 LOX IMVI cells, with IC
Background: Novel norfloxacin derivatives were synthesized, characterized, and screened for their antibacterial activity against Gram-positive strain S. aureus ATCC 6538 Gram-negative strains; E. coli 25923, K. pneumoniae 10031, P. aeruginosa 27853 using the agar cup diffusion method. Results: The results revealed that compounds 6–17 exhibited more potent towards with MIC values of 0.21–3.61 µM than a 7.83 µM. most compound, 6, showed 37-fold potency norfloxacin. More importantly, compound 7...
Background: Previous studies have reported various biological activities of indeno-pyridazine and thiazole derivatives, including antiviral activity CoV-19 inhibition. In this paper, the authors aimed to design, synthesize, characterize a novel series indenopyridazinethiazoles, starting with 2-(4-cyano-3-oxo-2,3-dihydro-9H-indeno[2,1-c]pyridazin-9-ylidene)-hydrazine-1-car-bothioamide available laboratory reagents. Methods: The strategy involved synthesis indeno[2,1-c]pyridazincarbothioamide,...
While the accessible pores render an enormous variety of functionalities to bulk metal-organic frameworks (MOFs), outer surfaces exposed by these crystalline materials also offer unique characteristics not available when using conventional substrates. By grafting hydrocarbon chains well-defined MOF thin films (SURMOFs) prepared layer-by-layer methods, we were able fabricate superhydrophobic substrates with static water contact angles over 160°. A detailed theoretical modelling grafted on...
A series of new quinazoline/1,2,3-triazole hybrids were designed and synthesized. The compounds evaluated as antiproliferative agents targeting EGFR, BRAF V600E .
This work outlines the design, synthesis, and biological evaluation of a new series benzimidazole/1,2,3-triazole hybrids as apoptotic antiproliferative agents that inhibit EGFR pathway. The research assesses efficacy compounds 6a-i 10a-i against various cancer cell lines. emphasizing 6i 10e for their remarkable activity, with GI50 values 29 nM 25 nM, respectively. inhibitory effects most potent 6e, 6i, 10d, 10e, 10g on were assessed. Compounds exhibited greater potency than erlotinib...
The present study aims to create spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide derivatives with anticancer activities. in vitro evaluation showed that only the novel spiro-acenaphthylene tethered-[1,3,4]-thiadiazole (compound 1) exhibited significant efficacy as a selective inhibitor of tumor-associated isoforms carbonic anhydrase. Compound 1 demonstrated considerable against renal RXF393, colon HT29, and melanoma LOX IMVI cancer cell lines, IC50 values 7.01 ± 0.39, 24.3 1.29,...
Analytical data in chemistry and other disciplines is usually generated different formats lacks common metadata standards that are necessary for a FAIR handling of research data. In the work presented herein, we describe workflow uses non-standardized, some cases proprietary, from cyclic voltammetry measurements coming individual devices as an instructive example, to yield open, standardized annotated with rich metadata. The includes concepts, software infrastructure can be used support...
Background/Objectives: New indole/1,2,4-triazole hybrids were synthesized and tested for antiproliferative activity against the NCI 60 cell line as tubulin polymerization inhibitors. Methods: All final compounds, 6a-j 7a-j evaluated at a single concentration of 10 µM panel sixty cancer lines. Results: Compounds 7a-j, featuring NO-releasing oxime moiety, exhibited superior anticancer to their precursor ketones across all 6h, 7h, 7i, 7j chosen five-dose evaluations comprehensive array human...
Siloxycarbenes induced via the visible light irradiation of acylsilanes undergo highly efficient “photo-click” chemistry reactions with electron deficient ketones. This process requires no reagents other than light, proceeds high efficiency and is tolerant a wide range functional groups. Pyruvate esters, thioesters, amides, nitriles phosphonates were all suitable electrophiles including those tethered to complex drug or biomolecule scaffolds. The was achieved on larger scale using both batch...
Abstract Phthalocyanine (PC)‐based metal–organic frameworks (MOFs) hold substantial promise for applications in energy storage, sensing, and catalysis due to their robust stability enhanced electron transfer capabilities. However, synthesizing phthalocyanine linkers with precise geometries presents a significant challenge, which limits prevalence the field. Traditional methods typically employ readily synthesized tetratopic PC realizing PC‐based MOFs. In response, study an innovative...
The dual targeting of EGFR and HER2 is an established anticancer strategy. A novel series including two distinct scaffolds, (chalcone-based compounds, 4a-n) B (pyrazoline-based 5a-n), was developed synthesized. antiproliferative efficacy 4a-n 5a-n examined against a panel four cancer cell lines. findings indicated that pyrazoline derivatives exhibited more than chalcone compounds 4a-n. Compounds 4n, 5d, 5g were identified as the most effective derivatives. These further investigated...
Introduction: Carbonic anhydrase IX (CA IX) is a tumor-associated enzyme involved in cancer progression and survival. Targeting CA with selective inhibitors like SLC-0111 has shown therapeutic potential. This study aimed to develop novel 4-pyridyl analog ( Pyr ) of enhanced anticancer activity. Methods: was synthesized using tail-based design characterized by NMR. Its cytotoxicity tested against normal cell lines. inhibition, cycle effects, apoptosis induction, protein expression changes...
Organelle targeting is an important area of research for studying organelle function and morphology, signaling, organelle-targeted drug delivery. Here, we report the development dual cycloalkyne reagents that can undergo click reactions with azides directly in choice (mitochondria endoplasmic reticulum (ER))—Mito-ER systems. The design Mito-ER systems based on benzothiophene-fused azacyclononyne BT9N, featuring a mito-targeting (thiophene) mitochondria-maintaining (thiourea) functional...
A series of Cu(I) complexes having 1,2,4-triazole as bridging ligand and aminophosphanes chelating [NP]-donors were successfully isolated spectroscopically characterized. The structure the derivatives was ascertained through...
Organelle targeting is an important area of research for studying organelle function and morphology, signaling, organelle-targeted drug delivery. Here, we report the development dual cycloalkyne reagents that can undergo click reactions with azides directly in choice (mitochondria endoplasmic reticulum (ER))—Mito-ER systems. The design Mito-ER systems based on benzothiophene-fused azacyclononyne BT9N, featuring a mito-targeting (thiophene) mitochondria-maintaining (thiourea) functional...
Chiral molecules are integral to various biological and artificial systems, influencing processes from chemical production optical activities. In this study, we explore the potential of chiral vinyl[2.2]paracyclophane (vinyl-PCP) as a monomer for synthesis homopolymers copolymers with styrene. We achieved polymerization through anionic, cationic, radical methods. The resulting polymers demonstrated significant properties, even in small fractions monomer. Further, developed polymerizable...
Tubulin polymerization inhibitors have emerged as interesting anticancer therapies. We present the design, synthesis, and structural elucidation of novel thiazole-based derivatives to identify tubulin with potent antiproliferative efficacy strong inhibition polymerization. The compounds consist two scaffolds. Scaffold A 10a-e scaffold B 13a-e. structures newly synthesized 13a-e were validated using 1H NMR, 13C elemental analysis. most effective antitubulin derivative was 10a, exhibiting an...
Abstract [2.2]Paracyclophane (PCP) has emerged as a versatile building block in polymer science owing to its unique bicyclic structure, rigidity, and inherent chirality. To promote this the broader public highlight versatility, paper provides concise overview of recent advancements PCP‐based polymers, including their synthesis, structural features, diverse applications. Functionalized PCP side chain backbone polymers exhibit remarkable properties, π‐stacking, tunable optoelectronic activity,...
Abstract Hyperphosphorescent organic light‐emitting diodes (HP‐OLEDs) represent an attractive solution to persistent efficiency roll‐off and device stability issues, combining phosphorescent sensitizers with fluorescent terminal emitters achieve efficient, narrowband emission. This review discusses advances in HP‐OLEDs where the emitter is a multiresonance thermally activated delayed fluorescence compound. Recent breakthroughs performance, including examples demonstrating both high maximum...