A5020585022- Ion Transport and Channel Regulation
- Ethics in Clinical Research
- Receptor Mechanisms and Signaling
- Cancer Genomics and Diagnostics
- Nitric Oxide and Endothelin Effects
- Erythrocyte Function and Pathophysiology
- Biomedical Ethics and Regulation
- Renin-Angiotensin System Studies
- Potassium and Related Disorders
- Bipolar Disorder and Treatment
- Electrolyte and hormonal disorders
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Health Systems, Economic Evaluations, Quality of Life
- Molecular Biology Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Protein Kinase Regulation and GTPase Signaling
- Pancreatic function and diabetes
- Sodium Intake and Health
- Cholesterol and Lipid Metabolism
- Hormonal Regulation and Hypertension
- Biosimilars and Bioanalytical Methods
- Forensic and Genetic Research
- Membrane-based Ion Separation Techniques
Inserm
2011-2023
Université Paris Cité
2002-2023
Délégation Paris 5
2018-2023
Medical University of Graz
2021-2023
University of Milano-Bicocca
2022-2023
Beijing Academy of Social Sciences
2023
Chinese Academy of Sciences
2022
Assistance Publique – Hôpitaux de Paris
2002-2019
Sorbonne Université
2003-2019
Pitié-Salpêtrière Hospital
2016-2019
An abnormally low sodium-potassium net flux ratio in erythrocytes was recently described human essential hypertension. We have confirmed this finding 65 patients with hypertension who were compared 33 normotensive controls born of parents. In 23 other subjects documented secondary and parents, the found to be similar that controls. The erythrocyte test thus appears interest distinguishing between Severe renal failure itself reduces would therefore distort results test.
Biological resources (cells, tissues, bodily fluids or biomolecules) are considered essential raw material for the advancement of health-related biotechnology, research and development in life sciences, ultimately improving human health. Stored local biobanks, access to biological samples related medical data transnational is often limited, particular international science industry. The recently established pan-European Biobanking BioMolecular Research Infrastructure-European Infrastructure...
We described in this paper studies on the modes of operation cuabain-insensitive sodium transport systems red cells normotensive and hypertensive patients. have extensively investigated properties Na countertransport cotransport order to clarify whether they are two different proteins or one protein with operation. Several criteria discrimination between pathways described: They differ their affinity for Li, sensitivity several inhibitors, changes cell volume, chloride replacement by...
A group of experts aided development a cost-related tool for biobank access prices and tested it in three partnership models.
Net fluxes of sodium and potassium ions were determined in sodium-loaded, potassium-depleted erythrocytes from 370 white subjects, 194 whom had essential hypertension or been born to parents with hypertension. Findings compared those 86 controls who normotensive did not have a family history Compared all patients low ratio secondary deficit the sodium-potassium cotransport system. A similar abnormality was found subjects hypertension, prevalences deficient system such being 53.6% (52 out 97)...
In erythrocytes from essential hypertensive patients and some of their normotensive offspring, the Na + ,K co-transport system is unable to transport in an uphill direction against electrochemical gradient. Recent studies kinetic properties this have permitted us further characterize abnormal hypertension.Thirty-four were characterized by a two-to three-fold decrease maximal rate outward partial uncoupling as compared with 22 controls. On other hand, normal was found five secondary...
Adipose cells specialized in energy storage, contain large intracellular triglyceride-rich lipid droplets, are enriched with free cholesterol, and express sterol-regulated transcription factors such as liver X receptor (LXR). The recent identification of the LXR-dependent ATP binding cassette transporter A1 (ABCA1) pathway for cholesterol release from peripheral has led us to address question expression function ABCA1 adipocytes. In 3T3-L1 adipose cells, we observed a strong induction mRNA...
This study examines the role of insulin and angiotensin II in high-density lipoprotein (HDL) metabolism by focusing on regulation function scavenger receptor type-BI (SR-BI) adipose tissue.Insulin or injection wild-type mice induced a decrease circulating HDL it was associated with translocation SR-BI from intracellular sites to plasma membrane tissue. Refeeding upregulated selective cholesteryl esters uptake proteins through transcriptional posttranscriptional mechanisms. occurred along...
Abstract: Biobanks play an important role in biomedical research that aims to understand cellular and molecular mechanisms underlying the development of diseases, improve interventions for human health. Despite financial support from mixed public funding streams, long-term sustainability biobanks remains a major concern. Review literature demonstrates total cost-recovery strategies, as well commercialization results or derived products, may not represent best way reach maintain...
In this report we provide an overview of the kinds data academics need in order to conduct independent research into political online safety matters on social media platforms, and challenges they currently face. Additionally, put forward ideas regarding novel governance structures that would enable high-quality research, while protecting users’ rights privacy, United Kingdom.
Scavenger receptor class B, type I (SR-BI) mediates the selective uptake of lipids from high density lipoproteins and is expressed in several types tissues. However, to date little known about its role adipocytes. In this study, we investigated cellular distribution SR-BI 3T3-L1 adipocytes regulation by hormones increase lipid storage such as angiotensin II (Ang II) insulin. was mainly distributed cytoplasm determined laser-scanning confocal analysis immunofluorescence labeling or study an...
Outward Na+ - K+ cotransport in erythrocytes from essential hypertensive Caucasian subjects was found to be excessively low (Co -) compared normotensives +) carefully selected for their negative family history of hypertension. Since the frequency hypertension varies widely among different populations and is particularly high certain coloured peoples, we erythrocyte normotensive Paris (France) Abidjan (Ivory Coast) seen whether defective related blood pressure African group as well. Of 66...