A5022435899- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalytic Cross-Coupling Reactions
- Crystallography and molecular interactions
- Asymmetric Hydrogenation and Catalysis
- Organoboron and organosilicon chemistry
- Synthesis and characterization of novel inorganic/organometallic compounds
- Catalytic C–H Functionalization Methods
- Organometallic Complex Synthesis and Catalysis
- Electrochemical Analysis and Applications
- Electrocatalysts for Energy Conversion
- Synthetic Organic Chemistry Methods
- Click Chemistry and Applications
- CO2 Reduction Techniques and Catalysts
- Metal complexes synthesis and properties
- Supramolecular Chemistry and Complexes
- Cyclopropane Reaction Mechanisms
- Organophosphorus compounds synthesis
- Radical Photochemical Reactions
- Coordination Chemistry and Organometallics
- Carbon dioxide utilization in catalysis
- Molecular Sensors and Ion Detection
- Nanomaterials for catalytic reactions
- Boron Compounds in Chemistry
University of York
2004-2024
University of Leeds
2014-2023
Curtin University
2019
University of Edinburgh
2016
Durham University
2007-2010
Stellenbosch University
2006
University of Bristol
2005
DSM (Netherlands)
2003-2004
There is a dire need for new compounds to combat antibiotic resistance: metal complexes might provide the solution. 906 were evaluated against dangerous ESKAPE pathogens and found have higher hit-rate than organic molecules.
This tutorial bridges an important knowledge gap by providing easily accessible introduction that enables synthetic chemists to explore electrochemistry.
Abstract Monodentate phosphoramidites based on BINOL or substituted are excellent ligands for the rhodium‐catalysed asymmetric hydrogenation of olefins. Very high enantioselectivities were obtained with MonoPhos ( 7a ) simplest member this class, a ligand that is prepared in single step from and HMPT. Turnover numbers up to 6000 have been dehydroamino acid derivatives. Enantioselectivities acids solvent dependent; non‐protic solvents they range 95–99%. Itaconic its dimethyl ester could be...
Site-selective dihalogenated heteroarene cross-coupling with organometallic reagents usually occurs at the halogen proximal to heteroatom, enabled by intrinsic relative electrophilicity, particularly in strongly polarized systems. An archetypical example is Suzuki-Miyaura (SMCC) of 2,4-dibromopyridine organoboron species, which typically exhibit C2-arylation site-selectivity using mononuclear Pd (pre)catalysts. Given that speciation, aggregation, known lead formation catalytically competent...
Silver–N-heterocyclic carbene complexes derived from natural xanthine products have been prepared. Chemosensitivity studies indicate a correlation between cytotoxicity, ligand sterics and hydrophilicity.
A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate show enhanced over monodentate macrocyclic ligands.
Improved synthesis through the use of alternating polarity.
Libraries of lanthanide complexes supported by nitrogen and oxygen containing ligands have been synthesised using a high-throughput approach. The were employed in the ring-opening polymerisation epsilon-caprolactone, some cases giving polycaprolactone controlled molecular weight narrow polydispersity. libraries, based on twenty-one eight reagents, developed order to determine best combination metal ligand. They prepared via transamination reactions [Ln[N(SiMe(3))(2)](3)] with tetradentate...
An electrochemical flow-cell has been developed for the highly efficient and selective generation of organometallic Cu<sup>I</sup>–N-heterocyclic carbene complexes under neutral ambient conditions.
A library of pyridyl- and picolyl-substituted imidazolium salts have been synthesized coordinated to copper, via transmetalation from silver(I)–N-heterocyclic carbenes (NHCs), prepare several copper(I)– copper(II)–NHC complexes. The copper(I)–NHCs are complexes the type Cu(NHC)Br, with solid-state structures revealing a variety coordination environments around copper centers. stability copper(II) is particularly unusual, given absence "hard" anionic tethering group appended ligands. has...
The cationic cages nido-[C2Bu(t)2P2E]+ (E = As, Sb), which are isolobal to the cyclopentadienyl cation, adopt square based pyramidal structures with heavy pnictogen atom at apex; NMR and computational methods have been used probe dynamic behaviour of complexes.
Reaction of two equivalents n-BuLi with sterically demanding amine-bis(phenol) compounds, H2O2NN′R (Me2NCH2CH2N{CH2-3,5-R2-C6H2OH}2; R = t-Bu or t-Pe (tert-pentyl)) yields isolable lithium complexes, Li2(O2NN′R), in good yields. Upon reaction one equivalent LnCl3(THF)x, the salts afford rare earth amine-phenolate chloride complexes yields, Ln(O2NN′R)Cl(THF); Ln Y, Yb, Ho, Gd, Sm, Pr. Crystals Y(O2NN′t-Bu)Cl(THF), 1, and Sm(O2NN′t-Bu)Cl(DME), 2, suitable for single crystal X-ray...
Abstract The preparation of a series imidazolium salts bearing N‐allyl substituents, and range substituents on the second nitrogen atom that have varying electronic steric properties, is reported. ligands been coordinated to copper(I) centre resulting copper(I)–NHC (NHC=N‐heterocyclic carbene) complexes thoroughly examined, both in solution solid‐state. solid‐state structures are highly diverse exhibit unusual geometries cuprophilic interactions. first structurally characterised complex...
A mechanistic investigation of Ullmann–Goldberg reactions using common bases led to the identification pathways for catalyst deactivation. The solid form inorganic phase was found have critical influence on mechanism reaction.
An electrochemical approach for the preparation of copper(I) N-heterocyclic carbene complexes has been developed to include a diverse range ligand precursors. Importantly, method is effective precursor that contains several acidic protons and which traditional methods formation are not suitable.
A small, sterically rigid tris(imidazolium) cyclophane reacts with Ag2O to give an Ag(I) carbene complex in which one of the imidazolium moieties remains protonated.
It is a matter of size: N-Heterocyclic carbenes can remove proton from ortho-carborane to form two-cage anion or attack the electropositive boron yield stable 1:2 carborane–carbene adduct. Which end product formed depends on steric bulk alkyl groups attached nitrogen atoms carbene. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited typeset. They made available submitted by authors. Please note: The...
A novel N-heterocyclic carbene 1,3-alternate calix[4]arene complex bearing four palladium(II) centers per ligand has been prepared. Electrochemical synthetic methods were used to prepare the corresponding copper(I) complex, followed by transmetalation onto palladium(II). The activity of palladium was probed in Suzuki–Miyaura cross-coupling reaction. An inverse correlation between concentration and observed, with results indicating that calix[4]arenes cone conformation may reduce aggregation...
Four brand new hybrid ligands combining an N-heterocyclic carbene tethered with two isomeric nido-dicarbaundecaborane dianions, a neutral closo-dicarbadodecaborane or anion are described. Versatile coordination of the to Rh(I) is demonstrated, in which both NHC and carborane moieties covalently coordinate metal centre.
A series of 12 silver(I)–N-heterocyclic carbene (NHC) complexes were prepared featuring five- (both saturated and unsaturated backbone), six-, seven-membered ring ligand scaffolds. The N-substituents the NHCs diisopropylphenyl in all cases, while anion was varied between bromide, acetate, triflate. evaluated as catalysts spirocyclization 1-(1H-indol-3-yl)-4-phenylbut-3-yn-2-one to give a spirocyclic indolenine product. To our knowledge, it is first time that systematic study has been...
Pure amine-bis(phenol) ligands are readily accessible in high yield, often >90%, when the Mannich condensation reactions performed “on water” or poly(ethyleneglycol) (PEG). Microwave-assisted synthesis dramatically reduces time and energy required to prepare these molecules, typically from 24 h 5 min. The approach seems be widely applicable (7 amines phenols were tested yield a diverse set of bis(phenol) ligands). Significant improvements observed for derived di-tert-amyl di-tert-butyl...
The synthesis of a series ruthenium(II) based anion sensors the type [Ru(eta(6)-C(6)H(4)MeCHMe(2))Cl(L)(2)][BF(4)] (2) is reported in which ligand L represents substituted pyridinylmethyl-amine derivatives. carbazole L(3) exhibits fluorescent intraligand charge-transfer (ILCT) state that quenched by ligand-to-metal charge transfer (LMCT) upon coordination to ruthenium 1:1 complex [Ru(eta(6)-C(6)H(4)MeCHMe(2))Cl(2)(L(3))] (1 c). 1:2 2 c fluorescent, however, and acts as sensor because mixing...
A series of tripodal imidazole frameworks (TIFs) are reported based on a tripodal, cavity-containing tris(imidazole) derivative. In the case [Co(3)Cl(6)(1)(2)]·n(solvent) (TIF-1) which possesses doubly interpenetrated framework structure, material exhibits rigid, permanent porosity and selectively absorbs CO(2). The non-interpenetrated [Co(1)(2)(H(2)O)(2)]Cl(2)·4H(2)O (TIF-2) also gases vapours fully reversibly exhibiting reversible phase change in process considerable conditioning...