A5023128005- Microbial Natural Products and Biosynthesis
- Diverse Approaches in Healthcare and Education Studies
- Diverse Topics in Contemporary Research
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Health and Wellbeing Research
- Healthcare Education and Workforce Issues
- Simulation-Based Education in Healthcare
- Education and Learning Interventions
- Fungal Biology and Applications
- Innovations in Medical Education
- Genomics and Phylogenetic Studies
- Marine and Coastal Research
- Medical Malpractice and Liability Issues
- Psychosocial Factors Impacting Youth
- Education, Safety, and Science Studies
- Steroid Chemistry and Biochemistry
- Synthetic Organic Chemistry Methods
- Listeria monocytogenes in Food Safety
- Microbial Metabolism and Applications
- Peptidase Inhibition and Analysis
- EEG and Brain-Computer Interfaces
- Trauma and Emergency Care Studies
- Chinese history and philosophy
- Ginseng Biological Effects and Applications
Kyungpook National University
2020-2025
Wonkwang University
2024-2025
Konkuk University
2023-2024
Korea University
2024
Ajou University
2016-2024
Sunchon National University
2023
Hanyang University
2023
Inha University
2008-2021
Yonsei University
2009-2021
Myongji University
2020-2021
Emerging evidence supports artificial intelligence-enhanced electrocardiogram (AI-ECG) for detecting acute myocardial infarction (AMI), but real-world validation is needed. The aim of this study was to evaluate the performance AI-ECG in AMI emergency department (ED). Rule-Out Myocardial Infarction using Artificial intelligence Electrocardiogram analysis (ROMIAE) a prospective cohort conducted Republic Korea from March 2022 October 2023, involving 18 university-level teaching hospitals. Adult...
Lipocalin-2 (Lcn2) is preferentially expressed in hepatocellular carcinoma (HCC). However, the functional role of Lcn2 HCC progression still poorly understood, particularly with respect to its involvement invasion and metastasis. The purpose this study was investigate whether associated epithelial-mesenchymal transition (EMT) elucidate underlying signaling pathway(s). well-differentiated versus liver cirrhosis tissues, expression positively correlated stage HCC. characteristics EMT were...
Cholangiocarcinoma (CC) is an intrahepatic bile duct carcinoma with a high mortality rate and poor prognosis. Sarcomatous change/epithelial mesenchymal transition (EMT) of CC frequently leads to aggressive spread metastasis. The aim this study was identify the genetic alterations gene expression pattern that might be associated sarcomatous change in CC. Previously, we established 4 human cell lines (SCK, JCK1, Cho-CK, Choi-CK). In present study, characterized typical sarcomatoid phenotype...
Abstract Background The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression genes related sarcomatous transdifferentiation. Methods Genes that were differentially expressed between cell lines or tissues cultured normal biliary epithelial (NBE) cells identified using DNA microarray technology. Expressions validated in human cells. Results Using unsupervised hierarchical clustering analysis...
Opa interacting protein 5 (OIP5) is upregulated in some types of human cancers, but the biological implications its upregulation have not yet been clarified hepatocellular carcinoma (HCC). In this study, signaling pathway downstream OIP5 was analyzed by proteome kinase profiling. A putative microRNA targeting identified using a miRNA PCR array. Tumorigenicity and metastatic ability were examined an orthotopic animal model. expression strongly detected early advanced tumors via gene profiling...
Abstract Purpose: The poor survival rate of hepatocellular carcinoma (HCC) is in part due to the inability diagnose patients at an early stage. Therefore, aim this study was search for candidate serum marker HCC and test their ability distinguish a from benign liver disease. Experimental Design: Genome-wide analysis by microarray 40 done between paired nontumor tissues. Expression cystatin B (CSTB) examined mRNA expression immunohistochemistry. CSTB levels were measured using sandwich ELISA...
Eph receptor 2 (EphA2) overexpression is frequently accompanied by the loss of its cognate ligand during tumor progression. However, molecular mechanism this ligand-independent promotion EphA2 remains unclear in highly malignant and fatal cholangiocarcinoma (CC). We examined biological role growth metastasis CC tissues cells according to degree differentiation we explored downstream signaling pathways EphA2. Growth factor-mediated itself leads activation mammalian target rapamycin complex 1...
Studies on gut microbiome changes in neonatal Korean indigenous calves with diarrhea are rare. In this study, 14 normal and 11 were selected from up to 30 days of age classified into three groups at 10-day intervals (1-10, 11-20, 21-30 days). Feces 25 collected, the diversity, similarity, structure, correlation analyzed. Firmicutes, Bacteroidetes, Proteobacteria predominant taxonomic composition regardless presence diarrhea. However, increased Bacteroidetes Actinobacteria decreased addition,...
The effects of citrus flavonoids on P-glycoprotein (P-gp)-mediated drug efflux were examined in human intestinal Caco-2 cells. cellular accumulation rhodamine-123 was measured using 10 for preliminary screening. Among the tested, diosmin significantly increased In bidirectional transport digoxin, apical-to-basal (A-to-B) but decreased basal-to-apical (B-to-A) both concentration- and time-dependent manners. digoxin ratio (B−A/A−B) estimated to be 2.3 at a concentration 50 μM diosmin, which...
Schisandra fruits (Schisandraceae) are often used in traditional medicine and can be taken concomitantly with conventional medicine. In this study, the effects of dibenzocyclooctadiene lignans from Schizandra chinensis on P-gp-mediated efflux were examined to investigate a possible interaction P-gp substrates. The cellular accumulation rhodamine-123 Caco-2 cells was measured 12 lignans. Most compounds resulted slight or moderate increases rhodamin-123 uptake, indicating their inhibitory...
Abstract Like humans, weight control in overweight dogs is associated with a longer life expectancy and healthier life. Dietary supplements are one of the best strategies for controlling obesity obesity-associated diseases. This study was conducted to assess potential black ginseng (BG) silkworm (SW) as diet-induced beagle dogs. To investigate changes that occur administered supplements, different obesity-related parameters, such body condition score (BCS), blood fatty acid profile,...
Rufomycin and ilamycin are synonymous for the same class of cyclopeptides, currently encompassing 33 structurally characterized isolates 9 semisynthetic derivatives. Elucidation new structures prioritized consolidation names established four diastereoisomeric rufomycins with a 2-piperidinone, named 4-7, including full 1H/13C NMR assignments. The characteristic HSQC cross-peak CH-5, hemiaminal carbon in amino acid #5, allows assignment stereocenters C-4 C-5 within this ring. Semisynthetic...
Oxidative stress is the main cause of cardiac injury during ischemia/reperfusion but molecular mechanism for this process unclear. In study, it was found that hypoxia induces apoptosis in rat embryonic heart-derived H9c2 cells leading to induction GADD153, which an apoptosis-related gene. Therefore, study addressed role GADD153 hypoxia-induced apoptosis. The stable or inducible overexpression sensitized apoptotic cell death. results suggest transactivation domain might be responsible...
Abstract A sensitive and rapid method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) combined with solid‐phase extraction (SPE) has been developed validated for the quantitative determination of enalapril its active metabolite enalaprilat in human plasma. After addition internal standard to plasma, samples were extracted by 96‐well SPE cartridge. The extracts analyzed HPLC detection analyte multiple reaction monitoring (MRM) mode. This simultaneous was accurate...
Cholangiocarcinoma (CC) is a chemoresistant intrahepatic bile duct carcinoma with poor prognosis. The aims of this study were to identify molecular pathways that enhance sesquiterpene lactone parthenolide (PTL)-induced anticancer effects on CC cells. PTL apoptosis and hemoxygenase-1 (HO-1) induction examined in cell lines. enhancement PTL-mediated by modulation HO-1 expression the mechanisms involved also an vitro system. Low concentrations (5 10 µM) led Nrf2-dependent induction, which...
A novel and simple method for detecting five glucosinolates (glucoalyssin, gluconapin, glucobrassicanapin, glucobrassicin, 4-methoxyglucobrassicin) in kimchi was developed using liquid chromatography-electrospray tandem mass spectrometry (LC-MS/MS). The chromatographic peaks of the were successfully identified by comparing their retention times, spectra. mobile phase composed (acetonitrile) B (water). As glucosinolate, relative quantities found through sinigrin, different compounds that have...