A5005659905- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Genetic and Kidney Cyst Diseases
- Renal and Vascular Pathologies
- Renal and related cancers
- Acute Kidney Injury Research
- Organ Transplantation Techniques and Outcomes
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Grief, Bereavement, and Mental Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Transplantation: Methods and Outcomes
- Genetic Syndromes and Imprinting
- Pediatric Urology and Nephrology Studies
- Neurological Complications and Syndromes
- Iron Metabolism and Disorders
- Atrial Fibrillation Management and Outcomes
- Alcohol Consumption and Health Effects
- Folate and B Vitamins Research
- Pharmacological Effects and Toxicity Studies
Keimyung University
2014-2025
Keimyung University Dongsan Medical Center
2020-2024
Seoul National University Hospital
2018-2023
Samsung Medical Center
2023
Seoul National University
2018-2020
Significance Statement Poor sleep is known to be related kidney function impairment. Using the UK Biobank cohort, including individuals self-reporting regular patterns of short, intermediate, or long duration, authors found that short duration was associated with higher prevalence CKD. In genetic analysis, risk score for but not significantly a CKD stages 3–5, suggesting causal effects on Two-sample Mendelian randomization using independent meta-analysis results from CKDGen Consortium...
Population-scale evidence for the association between dynamic changes in metabolic syndrome (MetS) status and alterations risk major adverse cardiovascular events (MACE) is lacking.To investigate whether recovery from or development of MetS a population associated with an altered MACE.Nationwide cohort study.An analysis based on National Health Insurance Database Korea.A total 27 161 051 persons who received national health screenings 2009 to 2014 were screened. Those history MACE excluded....
The aim of this study was to investigate the causal effects between atrial fibrillation (AF) and kidney function.We performed a bidirectional summary-level Mendelian randomization (MR) analysis implementing results from large-scale genome-wide association for estimated glomerular filtration rate (eGFR) by CKDGen (N = 765 348) AF 588 190) identify genetic instruments. inverse variance weighted method main MR used. For replication, an allele score-based individual-level data within UK Biobank...
Although the lungs are major targets for COVID-19 invasion, other organs—such as kidneys—are also affected. However, renal complications of not yet well explored. This study aimed to identify incidence acute kidney injury (AKI) in patients with and evaluate its impact on patient outcomes. retrospective included 704 who were hospitalized at two hospitals Daegu, Korea from February 19 March 31, 2020. AKI was defined according serum creatinine criteria Kidney Disease: Improving Global Outcomes...
The fatality of novel coronavirus disease 2019 (COVID-19) is precipitously increased in patients with underlying comorbidities or elderly people. Kidney transplant (KT) recipients are one the vulnerable populations for infection. COVID-19 infection KT might be a complicated and awkward situation, but there has been lack reports concerning this group. Herein, we demonstrated two distinct cases different clinical progress. first case was 36-year-old man who underwent 3 years ago. He diagnosed...
Cancer risk and epidemiology in pre-dialysis chronic kidney disease (CKD) warrant further investigation a large-scale cohort.We performed nationwide population-based study using the national health insurance database of Korea. We screened records from 18,936,885 individuals who received examination ≥ 2 times 2009 to 2016. Pre-dialysis CKD was identified based on serum creatinine dipstick albuminuria results. Individuals with preexisting cancer history, renal replacement therapy, or transient...
Metabolic syndrome (MetS) is linked to various chronic comorbidities, including kidney disease (CKD). However, few large studies have addressed whether recovery from MetS associated with reduction in the risks of such comorbidities.This nationwide population-based study Korea screened 10,664,268 people who received national health screening ≥ 3 times between 2012 and 2016. Those a history major cardiovascular events or preexisting CKD were excluded. We classified groups into four, according...
An investigation into the causality of effects physical activity and specific sedentary activities on kidney function in general population is warranted.In this observational cohort study, first, clinical associations prevalence stages 3-5 chronic disease (CKD) estimated glomerular filtration rate (eGFR) with activity, determined by self-report or objective wrist-band accelerometer results, (watching television, using a computer driving) were investigated 329 758 UK Biobank participants. To...
Phthalates are chemical risk factors of chronic kidney disease (CKD); however, little is known about temporal trends phthalate exposure and associated health risks among CKD patients. Such information even scarce for alternative plasticizers. patients were recruited from 2011 to 2020 in Korea (
Continuous renal replacement therapy (CRRT) is an important treatment modality for severe acute kidney injury. As such, the epidemiology of CRRT in Korea needs further investigation.We conducted a nationwide, population-based study analyzing claims data from National Health Insurance Service Korea. All index intensive care unit admission cases government-designated tertiary referral hospitals 2005 to 2016 were included. Patients with history or who under 20 years old not considered. In...
The association of lipid parameters with cardiovascular outcomes and the impact kidney function on this have not been thoroughly evaluated in chronic disease (CKD) patients diabetes. We reviewed National Health Insurance Database Korea, containing data 10,505,818 subjects who received routine check-ups 2009. analyzed profile major adverse events (MACEs) risk all-cause mortality a nationally representative cohort 51,757 lipid-lowering medication-naïve had CKD Advanced eGFR <30 mL/min/1.73 m2...
Further investigation of the causal effects psychologic wellbeing on kidney function is warranted.In this Mendelian randomization (MR) study, genetic instruments for positive affect, life satisfaction, depressive symptoms, and neuroticism were introduced from a previous genome-wide association study meta-analysis European individuals. Summary-level MR was performed using CKDGen data ancestry (n=567,460), additional allele score-based in individual-level White British UK Biobank participants...
South Korea stands out as a prominent nation relying heavily on living-donor transplants, with high incidence of kidney transplants. This study aimed to obtain objective data the psychological, social, and mental health status living donors in Korea. A questionnaire was administered at two tertiary hospitals between June 2020 November 2020. The survey covered demographic information, motives for donation, concerns during medical socioeconomic evaluation, pain assessment, quality life using...
<title>Abstract</title> Objective Smoking is a leading preventable cause of disease and death worldwide, with severe implications for individuals chronic kidney (CKD). Although smoking at younger age linked to higher mortality risk, the specific effects early on all-cause cardio-cerebrovascular diseases (CCVDs)-specific in CKD patients are not well established. This study aims examine association between smoking, intensity, CKD. Methods nationwide, population-based cohort utilized data from...
Background/Objectives: Although a healthy dietary pattern is modifiable lifestyle factor in the prevention of chronic kidney disease (CKD), studies that investigate association between diet and prevalent CKD patients with diabetes, using Korean Healthy Eating Index (KHEI), are lacking. Methods: This cross-sectional study included 1991 diabetes from eighth National Health Nutrition Examination Survey 2019–2021. A higher KHEI indicated healthier eating habits. was defined as an estimated...
ABSTRACT Aim Patients with autosomal dominant polycystic kidney disease (ADPKD) are at increased risk of premature mortality, morbidities and complications, which severely impair quality life. However, patient‐centered outcomes not consistently reported in trials ADPKD, can limit shared decision‐making. We aimed to identify important patients caregivers the reasons for their priorities. Methods Nominal group technique was adopted involving ADPKD who were purposively selected from eight...
The incidence and risk of Mycobacterium tuberculosis in people with predialysis CKD has rarely been studied, although prevalence is increasing certain countries where endemic. We aimed to investigate the association between active risks a nation moderate risk.In this nationwide retrospective cohort study, we reviewed National Health Insurance Database Korea, screening 17,020,339 who received national health two or more times from 2012 2016. Predialysis was identified consecutive laboratory...
The effects of specific macronutrients on kidney function independent total calorie intake have rarely been studied, although the composition macronutrient has reported to affect health outcomes. We aimed investigate ratios risk chronic disease (CKD) by Mendelian randomization (MR) analysis. study was an observational cohort mainly based UK Biobank and including MR First, we evaluated relative baseline composition—that is, number calories from each divided intake—of diets participants, used...
Objective To investigate the risk of major adverse cardiac and cerebrovascular events (MACCEs) all-cause death patients with controlled hypertension suggest benefits physical activity in their prognosis. Methods People aged 40–69 years from prospective UK Biobank cohort (UKB, n=220 026) retrospective Korean National Health Insurance Service (KNHIS, n=3 593 202) were included this observational study, excluding those previous cerebrocardiovascular diseases or without treatment. The study...
Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance-based metabolomic profiling and identified 26 metabolites in urine samples. collected samples from 201, 77, 47, 36 136 patients IgAN, membranous nephropathy, minimal change disease, lupus nephritis healthy controls, respectively. determined whether level associated the prognosis IgAN through Cox regression...
Objective Evidence related to the risk of kidney damage by proton pump inhibitor (PPI) initiation in patients with ‘underlying’ chronic disease (CKD) remains scarce, although PPI use is generally associated acute interstitial nephritis or incident CKD. We aimed investigate association between and adverse outcomes CKD absence any deterministic indications for usage. Design Retrospective observational study. Setting Korea National Health Insurance Service database from 2009 2017. Participants...
Abstract Anemia is a common complication of chronic kidney disease (CKD), impacting long-term outcomes such as mortality and morbidity. Analyzing NHANES data from 1999 through 2016 for adults aged ≥ 20 years, we assessed the mediating effects anemia biomarkers (hemoglobin, hematocrit, red cell distribution width [RDW], mean corpuscular hemoglobin concentration [MCHC]) on CKD-related by using hazard ratios biomarker-adjusted model. Of 44,099 participants, 7463 experienced all-cause death. Cox...