A5025168962- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Organ Transplantation Techniques and Outcomes
- Renal cell carcinoma treatment
- Cardiovascular Health and Disease Prevention
- Metabolism and Genetic Disorders
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Nutritional Studies and Diet
- Erythropoietin and Anemia Treatment
- Diabetes Treatment and Management
- Mesenchymal stem cell research
- Acute Kidney Injury Research
- Renal and related cancers
- Blood Pressure and Hypertension Studies
- Hip and Femur Fractures
- Cytomegalovirus and herpesvirus research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Systemic Sclerosis and Related Diseases
- Tissue Engineering and Regenerative Medicine
Soonchunhyang University Hospital
2015-2025
Dankook University
2024
Soonchunhyang University
2008-2024
Keimyung University
2022
Keimyung University Dongsan Medical Center
2022
Yeungnam University
2022
Weatherford College
2022
Chungnam National University
2022
Asan Medical Center
2013-2015
University of Ulsan
2014-2015
Abstract Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in aged kidney, role interaction between Sirt1 hypoxia‐inducible factor (HIF)‐1α largely unknown. In this study, we investigated whether HIF‐1α could be a deacetylation target effect their on age‐associated renal injury. Five‐week‐old (young) 24‐month‐old (old) C57Bl/6J mice were assessed for changes. Kidneys from showed increased infiltration CD68‐positive macrophages, higher extracellular matrix...
Chronic kidney disease (CKD) is associated with increased risk for cardiovascular diseases (CVD). We hypothesized that inadequate angiogenic response in uremic patients could result from dysfunction of bone marrow-derived stromal cells [mesenchymal stem (MSCs)]. investigated whether MSCs are functionally competent uremia induced by partial ablation C57Bl/6J mice. Uremic showed decreased expression vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)1 and cell-derived (SDF)-1α,...
Diabetic nephropathy (DN) is associated with high risk of cardiovascular disease and mortality. Exosomal microRNAs (miRNAs) regulate gene expression in a variety tissues play important roles the pathology various diseases. We hypothesized that exosomal miRNA profile would differ between DN patients without nephropathy. prospectively enrolled 74 participants, including healthy volunteers (HVs), diabetic nephropathy, those DN. The serum profiles participants were examined using RNA sequencing....
Mesenchymal stem cells (MSCs) are promising source of cell-based regenerative therapy. In consideration the risk allosensitization, autologous MSC-based therapy is preferred over allogenic transplantation in patients with chronic kidney disease (CKD). However, it remains uncertain whether adequate cell functionality maintained under uremic conditions. As inflammation and oxidative stress CKD may lead to accumulation senescent cells, we investigated cellular senescence MSCs determined effects...
Background/Aims The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new must be validated in variety cohorts. We investigated whether these features were applicable to an adult Korean population. Methods In total, 69 patients with IgAN analyzed using the at Soonchunhyang University Hospital, Seoul, Korea. All cases categorized according Lee's classification. Renal biopsies...
Objective Exosomal microRNAs (miRNAs) are potential biomarkers for obesity, in which they regulate biological processes. Bariatric surgery has health benefits patients with obesity; however, the mechanisms of these not clear. This study attempted to identify exosomal miRNA signature associated obesity and how it changed after bariatric surgery. Methods Healthy volunteers (HVs) nondiabetic were prospectively enrolled study. The assessed serum profiles HVs using RNA sequencing. To evaluate...
Although hypertension is a well-known risk factor for chronic kidney disease (CKD), the blood pressure (BP) at which antihypertensive interventions should be initiated remains to determined. Therefore, we investigated association between BP and CKD in treatment-naïve individuals.This prospective cohort study considered 7,343 individuals Korean Genome Epidemiology Study who were not taking medications. Subjects categorized into six groups according their systolic (SBP) five diastolic (DBP)....
<h3>Objective</h3> The optimal consensus concerning treatment of incidental small paraclinoid unruptured intracranial aneurysms (UIAs) remains controversial. aim this retrospective study was to reveal the natural history UIAs with goal informing plan. <h3>Methods</h3> 524 patients harbouring 568 (≤5 mm) were retrospectively evaluated during mean follow-up 35.4 months. divided into two groups respect arterial branch: related (ophthalmic and superior hypophyseal artery), non-related. Medical...
Tubular injury and fibrosis are associated with progressive kidney dysfunction in advanced glomerular disease. Glomerulotubular crosstalk is thought to contribute tubular injury. microRNAs (miRNAs) extracellular vesicles (EVs) can modulate distant cells. We hypothesized that miRNAs EVs derived from injured podocytes lead epithelial cell damage. As proof of this concept, (HK2) cells were cultured exosomes puromycin-treated or healthy human podocytes, damage was assessed. Sequencing analysis...
Introduction Obesity is a risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease. T2DM increases the of cardiovascular-related death. We investigated changes in circulating exosomal microRNA (miRNA) profiles patients with DM obesity compared without obesity. Research design methods This prospective study involved 29 (patients DM=16, DM=13) healthy volunteers (HVs) (n=18). measured levels miRNAs by next-generation sequencing miRNA across three groups. Results The...
Background. It is well established that the survival rate of diabetic end-stage renal disease patients remains lowest among all primary diagnoses probably because higher prevalence cardiovascular diseases (CVD) associated with diabetes. This study was designed to evaluate impact CVD and other risk factors individually or in combination on mortality peritoneal dialysis (PD) patients.
A 65-year-old man was transferred from the Department of Vascular Surgery to Nephrology because cardiac arrest during hemodialysis. He underwent incision and drainage for treatment a buttock abscess. Nafamostat mesilate used as an anticoagulant hemodialysis address bleeding site. Sudden occurred after 15 minutes dialysis. The patient treated in intensive care unit 5 days. Continuous veno-venous hemodiafiltration started without any unit. Conventional reinitiated, nafamostat again small...
Introduction We previously reported the significant upregulation of eight circulating exosomal microRNAs (miRNAs) in patients with diabetic kidney disease (DKD). However, their specific roles and molecular mechanisms remain unknown. Among miRNAs, we evaluated effects miR-5010-5p on renal tubular epithelial cells under conditions this study. Research design methods transfected cell line, HK-2, an mimic using recombinant plasmids. The target gene hsa-miR-5010-5p was identified a...
Cytomegalovirus (CMV) infection is a frequent complication after kidney transplantation (KT) and has various effects on recipient graft survival. Although guidelines recommend anti-viral prophylaxis with ganciclovir or valganciclovir, there demand for alternative regimen CMV prevention. We investigated the of 3-month valacyclovir-based clinical outcomes in KT recipients using nationwide cohort. Overall, 2,584 from 20 transplant centers registered Korean Organ Transplantation Registry between...
Background Proton pump inhibitor use is associated with incident chronic kidney disease, disease progression and end-stage renal disease. However, the extent of proton prescriptions to patients still unclear. Method In a retrospective study, we enrolled (>18 years old) who received in out-patient setting from 2014 through 2015. All data was obtained electronical medical records Soonchunhyang Medical Center. The prescription patterns characteristics inhibitors were analyzed according...
Abstract Background Extracellular vesicle (EV)-microRNAs (miRNAs) are potential biomarkers for various renal diseases. This study attempted to identify the circulating EV-miRNA signature not only discriminating idiopathic membranous nephropathy (IMN) from nephrotic syndrome (INS), but also predict treatment response of patients with IMN. Methods We prospectively enrolled 60 participants, including those IMN (n = 19) and INS 21) healthy volunteers (HVs; n 20) in this study. Using RNA...
The beneficial effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors in patients with chronic kidney disease (CKD) low albuminuria levels have not been established. This study aimed to compare the dapagliflozin on injury biomarkers CKD stratified by level. We prospectively enrolled healthy volunteers (HVs; n = 20) and ( 54) without diabetes mellitus. Patients were divided into two age‐matched sex‐matched subgroups according urinary albumin–creatinine ratio (uACR) (<300 mg/g ≥300...
Abstract Anemia is a common complication of chronic kidney disease (CKD), impacting long-term outcomes such as mortality and morbidity. Analyzing NHANES data from 1999 through 2016 for adults aged ≥ 20 years, we assessed the mediating effects anemia biomarkers (hemoglobin, hematocrit, red cell distribution width [RDW], mean corpuscular hemoglobin concentration [MCHC]) on CKD-related by using hazard ratios biomarker-adjusted model. Of 44,099 participants, 7463 experienced all-cause death. Cox...
Abstract Mitochondrial injury plays important roles in the pathogenesis of various kidney diseases. However, mitochondrial IgA nephropathy (IgAN) remains largely unexplored. Here, we examined associations among injury, IgAN, and treatment outcomes. We prospectively enrolled patients with IgAN age-/sex-matched healthy volunteers (HVs) as controls ( n = 31 each). Urinary copy numbers DNA (mtDNA) genes cytochrome-c oxidase-3 COX3 ) nicotinamide adenine dinucleotide dehydrogenase subunit-1 ND1...
Abstract Background Kidney injury molecule-1 (KIM-1) is a biomarker useful for detecting early tubular damage and has been recently reported as marker evaluating kidney in IgA nephropathy (IgAN). We therefore investigated whether treatment decreases urinary KIM-1 excretion IgAN. Methods prospectively enrolled 37 patients with biopsy-proven Urinary was assessed before after treatment, which included low salt diet, blood pressure control, pharmacotherapy angiotensin receptor blockers and/or...
Background The elevation of serum creatinine (SCr), acute kidney injury (AKI), is associated with an increase mortality in critically ill patients. However, it uncertain whether a decrease SCr the intensive care unit (ICU) has effect on outcomes. Methods In retrospective study, we enrolled 486 patients who had been admitted to urban tertiary center ICU between Jan 2014 and Dec 2014. changes after admission 90 day was analyzed. Patients were classified into 3 groups based change admission:...
We reported a functional incompetence in mesenchymal stem cells (MSCs) under uremia, but the mechanisms have not been explored. To study of dysfunctional MSCs induced by we characterized insulin signaling and investigated effect uremic toxin, p-cresol, on proangiogenic actions insulin. In MSCs, hypoxia-inducible factor (HIF)-1α, vascular endothelial growth factor, stromal cell-derived 1α expressions via PI3K/Akt-dependent pathway. treated with p-cresol exhibited altered selective manner for...