A5005809729- Diet and metabolism studies
- Healthcare and Venom Research
- Circadian rhythm and melatonin
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Complications and Syndromes
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- Cancer-related gene regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Barrier Structure and Function Studies
- Acupuncture Treatment Research Studies
- Bioactive Compounds in Plants
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Amino Acid Enzymes and Metabolism
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Gastric Cancer Management and Outcomes
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Shoulder Injury and Treatment
Keimyung University
2016-2025
Keimyung University Dongsan Medical Center
2013-2023
Severance Hospital
2023
Ajou University
2014
Kyung Hee University
2006-2010
Kyung Hee University Medical Center
2004-2007
Abstract: The prevalence of diabetes has exponentially increased in recent decades due to environmental factors such as nocturnal lifestyle and aging, both which influence the amount melatonin produced pineal gland. present study investigated effect on signaling pathways glucose transport C 2 12 mouse skeletal muscle cells. Intriguingly, treatment cells with (1 n m ) stimulated uptake twofold increase. Melatonin‐stimulated was inhibited co‐treatment receptor antagonist luzindole....
Methamphetamine (METH) is a powerful addictive psychostimulant that gives rise to severe abusers worldwide. While many studies have reported on the neurotoxicity of METH, blood–brain barrier (BBB) dysfunction has recently attracted attention as an essential target in METH-induced pathological changes brain. However, its mechanism not been fully understood. We found METH increased paracellular permeability and decreased vascular integrity through FITC–dextran trans-endothelial electrical...
The pandemic outbreak of COVID-19 in the year 2020 that drastically changed everyone's life has raised urgent and intense need for development more efficacious antiviral material. This study was designed to develop copper nanoparticles (Cu NPs) as an agent validate activities developed NP. Cu NPs were synthesized using a high energy electron beam, characteristic morphologies evaluated. We found are spherical shape uniformly distributed, with diameter around 100 nm, opposed irregular...
The objective of this study was to investigate serial changes for histology joint capsule and range motion the glenohumeral after immobilization in rats. We hypothesized that a rat shoulder contracture model using would be capable producing effects on similar those seen patients with frozen shoulder. Sixty-four Sprague-Dawley rats were randomly divided into one control group (n = 8) seven groups 8 per group) immobilized molding plaster 3 days, or 1, 2, 3, 4, 5, 6 weeks. At each time point,...
β-hydroxybutyrate (β-OHB) has been shown to exert an anti-inflammatory activity. Apolipoprotein-E (ApoE) is strongly associated with atherosclerosis and Alzheimer's disease (AD). This study aimed explore the therapeutic effect of β-OHB in brain aorta high-fat diet (HFD)-fed ApoE-deficient mice. We found Apo-E deficient mice that attenuated lipid deposition choroid plexus (ChP) decreased amyloid plaque substantia nigra pars compacta. also CD68-positive macroglia infiltration ChP β-OHB-treated...
Abstract: Vitiligo is an acquired pigmentary disorder characterized by well‐circumscribed depigmented patches. Autoimmune, self‐destruction, neural, and genetic theories have been proposed for the pathogenesis of vitiligo. Reactive oxygen species play important role in physiology cell damage, catalase known to regulate oxidative stress. Reduced enzyme activity accumulation excessive hydrogen peroxide were observed To examine whether gene polymorphisms are associated with vitiligo patients...
The excessive proliferation and migration of synoviocytes are well-characterized phenomena that play key roles in the pathophysiology rheumatoid arthritis (RA). Melatonin has been shown to have potent anti-proliferative effect various cancer cells such as breast prostate cells. In this study, we examined role melatonin on synoviocyte primary cultured human fibroblast-like (FLSs) by analyzing protein expression P21(CIP1) (P21) P27(KIP1) (P27), cyclin-dependent kinase inhibitors important cell...
Nocturnal pain is commonly observed in patients with shoulder disorders such as a rotator cuff tear or frozen shoulder. This study was conducted to explore the possibility that melatonin plays role mediator of nocturnal shoulder.Subacromial bursa and joint capsule samples were collected from sixty-three patients: twenty-one tear, twenty-two shoulder, twenty instability (control group). The expression receptor 1A (MTNR1A) 1B (MTNR1B) acid-sensing ion channel 3 (ASIC3) subacromial determined...