A5005729051- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Radiomics and Machine Learning in Medical Imaging
- Nanoparticle-Based Drug Delivery
- Radiation Detection and Scintillator Technologies
- RFID technology advancements
- Lanthanide and Transition Metal Complexes
- Fetal and Pediatric Neurological Disorders
- Functional Brain Connectivity Studies
- Characterization and Applications of Magnetic Nanoparticles
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- IPv6, Mobility, Handover, Networks, Security
- NMR spectroscopy and applications
- RNA Interference and Gene Delivery
- Cerebral Palsy and Movement Disorders
- Neurological disorders and treatments
- Advanced NMR Techniques and Applications
- Bone and Joint Diseases
- Amyotrophic Lateral Sclerosis Research
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
Seoul National University
2009-2024
Seoul National University Hospital
2007-2023
New Generation University College
2007-2018
Zhejiang University of Technology
2017
Monash University
2015
Florey Institute of Neuroscience and Mental Health
2015
Melbourne Health
2015
The University of Melbourne
2015
Sungkyunkwan University
2012
Korea Institute of Science and Technology
2010
Abstract Various inorganic nanoparticles have been used as magnetic resonance imaging (MRI) contrast agents due to their unique properties, such large surface area and efficient contrasting effect. Since the first use of superparamagnetic iron oxide (SPIO) a liver agent, nanoparticulate MRI attracted lot attention. Magnetic extensively ability shorten T2* relaxation times in liver, spleen, bone marrow. More recently, uniform ferrite with high crystallinity successfully employed new T2...
Magnetic, fluorescent core–shell nanoparticles consist of a single Fe3O4 nanocrystal core and dye-doped mesoporous silica shell with poly(ethylene glycol) coating (see picture TEM images schematic depictions). These can be used as magnetic resonance fluorescence imaging agents, drug delivery vehicles, thus making them novel candidates for simultaneous cancer diagnosis therapy. Detailed facts importance to specialist readers are published "Supporting Information". Such documents...
Highly versatile nanocomposite nanoparticles were synthesized by decorating the surface of mesoporous dye-doped silica with multiple magnetite nanocrystals. The superparamagnetic property nanocrystals enabled to be used as a contrast agent in magnetic resonance (MR) imaging, and dye molecule framework imparted optical imaging modality. Integrating multitude on resulted remarkable enhancement MR signal due synergistic magnetism. An anticancer drug, doxorubicin (DOX), could loaded pores...
Core/shell upconverting nanoparticles (UCNPs) of NaGdF4:Er3+,Yb3+/NaGdF4 (see figure) are shown to serve as a multimodal imaging probe that works for both background-free optical and magnetic resonance (MRI). The nonblinking nonbleaching properties UCNPs can contribute minimization possible artifacts in long-term experiments. Owing Gd3+ ions the host matrix, contrast is enhanced T1-weighted MRI.
The recent advances in molecular imaging techniques, using cancer-targeting nanoparticle probes, provide noninvasive tracking information on cancer cells living subjects. Here, we report a multimodal cancer-targeted system capable of concurrent fluorescence imaging, radionuclide and MRI vivo. <b>Methods:</b> A cobalt–ferrite surrounded by fluorescent rhodamine (designated MF) within silica shell matrix was synthesized with the AS1411 aptamer (MF-AS1411) that targets nucleolin (a cellular...
To evaluate the potential of diffusion-weighted (DW) magnetic resonance (MR) imaging with an apparent diffusion coefficient (ADC) map in prediction response to neoadjuvant chemotherapy patients breast cancer.This retrospective study was approved by institutional review board, which waived informed consent requirement. Fifty-three consecutive women (mean age, 43.7 years; median 42.0 age range, 24-65 years) 53 invasive cancers diameter, 5.0 cm; 4.2 diameter 2.0-13.3 cm) who had undergone were...
OBJECTIVE: The purpose of this study was to determine the differences in signal intensity between brain abscesses and necrotic or cystic tumors on diffusion-weighted MR imaging. CONCLUSION: Five consecutive patients with proven four were prospectively evaluated On imaging, showed markedly hyperintense all five patients, whereas revealed hypointense patients. Diffusion-weighted imaging may allow differentiation abscess from tumor.
There is an apparent overlap between areas in the USA where herbicide, atrazine (ATZ), heavily used and obesity-prevalence maps of people with a BMI over 30. Given that herbicides act on photosystem II thylakoid membrane chloroplasts, which have functional structure similar to mitochondria, we investigated whether chronic exposure low concentrations ATZ might cause obesity or insulin resistance by damaging mitochondrial function. Sprague-Dawley rats (n = 48) were treated for 5 months (30 300...
We synthesized various hollow oxide nanoparticles from as-prepared MnO and iron nanocrystals. Heating metal nanocrystals dispersed in technical grade trioctylphosphine (TOPO) at 300 degrees C for hours yielded retaining the size shape uniformity of original The method was highly reproducible could be generalized to synthesize sizes, shapes, compositions. Control experiments revealed that impurities TOPO, especially alkylphosphonic acid, were responsible etching structures. Elemental mapping...
The most investigated semiconductor photosensor for MRI-compatible PET detectors is the avalanche photodiode (APD). However, silicon photomultiplier (SiPM), also called Geiger-mode APD, gaining attention in development of next generation PET/MRI systems because SiPM has much better performance than APD. We have developed an system based on multichannel arrays to allow simultaneous PET/MRI. <b>Methods:</b> scanner consists 12 detector modules with a ring diameter 13.6 cm and axial extent 3.2...
Heterostructured nanoparticles composed of metals and Fe3O4 or MnO were synthesized by thermal decomposition mixtures metal−oleate complexes (for the oxide component) metal−oleylamine metal component). The products included flowerlike-shaped Pt−Fe3O4 Ni−Fe3O4 snowmanlike-shaped Ag−MnO Au−MnO. Powder X-ray diffraction patterns showed that these face-centered cubic (fcc)-structured fcc-structured metals. relaxivity values Au−MnO Au−Fe3O4 similar to those nanoparticles, respectively....
Magnetische, fluoreszierende Kern-Schale-Nanopartikel, die aus einem Fe3O4-Nanokristallkern und einer farbstoffdotierten mesoporösen Kieselgelhülle mit Polyethylenglycol-Beschichtung bestehen (siehe TEM-Bilder schematische Darstellung), können als Magnetresonanz- Imaging-Agentien sowie zum Wirkstofftransport eingesetzt werden, was sie zu neuartigen Kandidaten für eine simultane Krebsdiagnose -therapie macht. Detailed facts of importance to specialist readers are published as "Supporting...
We report tumor targeting nanoparticles for optical/MR dual imaging based on self-assembled glycol chitosan to be a potential multimodal probe. To develop an probe, biocompatible and water-soluble (Mw = 50 kDa) were chemically modified with 5β-cholanic acid (CA), resulting in amphiphilic chitosan-5β-cholanic conjugates (GC-CA). For optical near-infrared fluorescence (NIRF) dye, Cy5.5, was conjugated GC-CA Cy5-labeled (Cy5.5-GC-CA). Moreover, order chelate gadolinium (Gd(III)) the Cy5.5-GC-CA...
Abstract Purpose: To investigate whether a correlation exists between perfusion parameters obtained from dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) and prognostic factors or immunohistochemical subtypes of breast cancers. Materials Methods: Quantitative (K trans , k ep v e ) 70 invasive ductal carcinomas were using DCE‐MRI as postprocessing procedure. Correlations factors, including tumor size, axillary nodal status, histologic grade, nuclear expression estrogen...
We report a novel and facile method for the synthesis of manganese oxide (Mn3O4) nanocrystals with various sizes shapes. Mn3O4 were synthesized via reaction manganese(II) acetate water in xylene presence surfactants at temperature as low 90 °C air atmosphere. Structural characterizations revealed that tetragonal structure they highly crystalline spite temperature. The size shape readily controlled by varying experimental conditions such precursors, surfactants, injection water. Nanoplates...
To evaluate the added value of diffusion-weighted imaging (DWI) in combination with T(2) weighted (T2WI) compared T2WI alone or positron emission tomography (PET)/CT for detecting viable tumour after neoadjuvant chemoradiation therapy (CRT) patients locally advanced rectal cancer.50 consecutive cancer (≥T3 lymph node positive) who underwent CRT and subsequent surgery were enrolled this retrospective study. All 3.0 T MRI PET/CT completing CRT. For qualitative analysis, two radiologists...
This study explored differences in frontal white-matter (WM) integrity between methamphetamine (MA) abusers and healthy comparison subjects using diffusion tensor imaging (DTI). Fractional anisotropy (FA) values, which indicate WM integrity, were calculated for regions-of-interest on images of 32 MA 30 subjects. Frontal executive functions also assessed by the Wisconsin Card Sorting test (WCST). had significantly lower FA values bilateral at anterior commissure–posterior commissure (AC–PC)...
Silicon photomultiplier (SiPM; also called a Geiger-mode avalanche photodiode) is promising semiconductor photosensor in PET and PET/MRI because it intrinsically MRI-compatible has internal gain timing properties comparable to those of tube. In this study, we have developed small-animal system using SiPMs lutetium gadolinium oxyorthosilicate (LGSO) crystals performed physical evaluation animal imaging studies show the feasibility system. <b>Methods:</b> The SiPM consists 8 detectors, each...
An imaging system that can be used to evaluate the expression levels of microRNAs during neuronal development provide noninvasive information for investigating a variety biological phenomena related (miRNAs, miRs). Herein, novel platform monitor intracellular miR124a differentiation is reported using rhodamine-coated cobalt ferrite magnetic fluorescent (MF) nanoparticles linked quenching molecular containing an binding sequence (MF-miR124a beacon). During differentiation, in vitro...
For attenuation correction (AC) in PET/MRI systems, segmentation-based methods are most often used. However, the standardized uptake value (SUV) of lesions bone and liver, which have higher coefficients than other organs, can be underestimated, potentially leading to misinterpretation clinical cases. Errors SUV estimation also dependent on segmentation schemes used AC. In this study, potential bias using 4 different AC was evaluated for PET/CT data cancer patients with liver lesions....
Abstract We synthesized manganese oxide (MnO and Mn 3 O 4 ) nanocrystals with various sizes shapes by the thermal reaction of a II –oleate complex through “heat‐up process”. When was thermally decomposed in non‐coordinating hydrocarbon solvents, uniformly sized MnO cubic octahedral were produced. able to synthesize anisotropic, multibranched oriented attachment truncated‐nanocube building blocks. heated 1‐hexadecene presence strongly coordinating carboxylic acid surfactants, spherical...
Visualization of biologic processes at molecular and cellular levels has revolutionized the understanding treatment human diseases. However, no single biomedical imaging modality provides complete information, resulting in emergence multimodal approaches. Combining state-of-the-art PET MRI technologies without loss system performance overall image quality can provide opportunities for new scientific clinical innovations. Here, we present a multiparametric PET/MR imager based on small-animal...