About
Contact & Profiles
A5072826367
Research Areas
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
ShanghaiTech University
2022
Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis (OA) "difficult-to-treat". Cartilage destruction is central to OA patho-etiology and mediated by matrix degrading enzymes. Here we report decreased expression of miR-17 in osteoarthritic chondrocytes its deficiency contributes progression. Supplementation exogenous or endogenous induction growth differentiation factor 5, effectively prevented simultaneously targeting pathological catabolic factors including...
10.1038/s41467-022-30119-8
article
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cc-by
Nature Communications
2022-05-04
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