A5103239191- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Osteoarthritis Treatment and Mechanisms
- Graphene and Nanomaterials Applications
- Bone health and treatments
- Sarcoma Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Medicinal Plant Pharmacodynamics Research
- Signaling Pathways in Disease
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Bone health and osteoporosis research
- Bone Tumor Diagnosis and Treatments
- Knee injuries and reconstruction techniques
- Medicinal Plants and Bioactive Compounds
- Telomeres, Telomerase, and Senescence
- Estrogen and related hormone effects
- Phytochemical Studies and Bioactivities
- Peptidase Inhibition and Analysis
- Pharmacological Effects of Natural Compounds
Xuzhou Medical College
2015-2024
Nanjing Medical University
2016-2024
Affiliated Hospital of Xuzhou Medical College
2007-2016
Alabama Agricultural and Mechanical University
1994
Diabetes mellitus is a chronic metabolic disease with proinflammatory microenvironment, causing poor vascularization and bone regeneration. Due to the lack of effective therapy one-sided focus on direct angiogenic properties biomaterials osteogenesis stimulation, treatment diabetic defect remains challenging complex. In this study, using gelatin methacryloyl (GelMA) as template, lithium (Li) -modified bioglass-hydrogel for regeneration developed. It exhibits sustained ion release better...
Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis (OA) "difficult-to-treat". Cartilage destruction is central to OA patho-etiology and mediated by matrix degrading enzymes. Here we report decreased expression of miR-17 in osteoarthritic chondrocytes its deficiency contributes progression. Supplementation exogenous or endogenous induction growth differentiation factor 5, effectively prevented simultaneously targeting pathological catabolic factors including...
Accumulating studies have shown that oxidative stress increases with aging, which is related to the pathophysiology of postmenopausal osteoporosis.Pyrroloquinoline quinone (PQQ) a natural anti-oxidant anti-oxidative and anti-aging effects.However, it unclear whether PQQ has protective role against estrogen deficiency-induced osteoporosis.Here, we evaluated efficacy on bone mineral density, microarchitecture, turnover biomechanical strength in ovariectomy (OVX)-induced osteoporosis mouse...
Three-dimensional honeycomb porous carbon (HPC) has attracted increasing attention in bioengineering due to excellent mechanical properties and a high surface-to-volume ratio. In this paper, three-dimensional chitosan (CS)/honeycomb carbon/hydroxyapatite composite was prepared by nano-sized hydroxyapatite (nHA) on the HPC surface situ deposition, dissolved solution, vacuum freeze-dried. The structure composition of CS/HPC/nHA were characterized scanning electron microscopy, transmission...
The bone immune microenvironment (BIM) regulates regeneration and affects the prognosis of fractures. However, there is currently no effective strategy that can precisely modulate macrophage polarization to improve BIM for regeneration. Herein, a hybridized biphasic bionic periosteum, inspired by functional structure natural presented. gel phase composed genipin-crosslinked carboxymethyl chitosan collagen self-assembled hybrid hydrogels, which act as "dam" intercept IL-4 released during...
Intervertebral disc degeneration (IVDD) is commonly caused by imbalanced oxygen metabolism-triggered inflammation. Overcoming the shortcomings of antioxidants in IVDD treatment, including instability and lack targeting, remains challenging. Microfluidic surface modification technologies were combined to graft chitosan nanoparticles encapsulated with strong reductive black phosphorus quantum dots (BPQDs) onto GelMA microspheres via amide bonds construct metabolism-balanced engineered hydrogel...
Treatment resistance of the tumors to photodynamic therapy (PDT) owing O2 deficiency largely compromised therapeutic efficacy, which could be addressed via modulating oxygen levels by using self-enriched nanosystems. Here, we report on augmenting O2-evolving strategy based a biomimetic, catalytic nanovehicle (named as N/P@MCC), constructed catalase-immobilized hollow mesoporous nanospheres enveloping cancer cell membrane (CCM), acts an efficient nanocontainer accommodate nitrogen-doped...
Abstract: Chondrosarcoma is the second most common type of primary bone malignancy in United States after osteosarcoma. Surgical resections these tumors are only effective treatment to chondrosarcoma patients due their resistance conventional chemo- and radiotherapy. In this study, miR-125b was found perform its tumor-suppressor function inhibit glucose metabolism via direct targeting oncogene, ErbB2. We report downregulated both patient samples cell lines. The total 20 Asian showed...
Nanocomposite scaffold materials have shown great prospect in promoting bone integration and regeneration. A three-dimensional graphene oxide foam/polydimethylsiloxane/zinc silicate (GF/PDMS/ZS) for tissue engineering was synthesized via dip coating hydrothermal synthesis processes, resulting the interconnected macroporous structure. The characterized with scanning electron microscopy (SEM), X-ray diffraction (XRD), photoelectron spectroscopy (XPS), thermogravimetric (TG) analysis. result...
The overall objective of this study was to investigate the mechanism inflammation on chondrocyte injury and protective effect catalpol chondrocytes in an inflammatory environment. Chondrocytes were isolated cultured from knee joints three-day-old newborn mice. Alcian Blue staining immunocytochemistry type II collagen used identify purity chondrocytes. Primary stimulated by IL-1β (10 ng/mL) subjected transcriptome analysis. Differentially expressed genes (DEGs) further analyzed based Gene...
This study was aimed to reveal the changes in survival rates and prognostic factors of chondroblastic osteosarcoma (COS). Patients from Surveillance, Epidemiology, End Results (SEER) database were retrieved. Kaplan–Meier analysis Cox proportional hazard model used during analysis. There significant differences on overall between subtypes (P < .001*). Overall COS did not change significantly last forty years = .610), cancer-specific increased a plateau 1980s then remained stable .058)....
Abstract Background Biological composite scaffolds are increasingly being used in abdominal wall reconstruction but still have certain shortcomings. The present study describes here a novel three-dimensional (3D) scaffold fabricated by combining 3D printing (3DP) and electrospinning (ESP). Methods composed of integrated 3DP interconnected macrofiber random ESP microfiber networks. retains intact architecture mechanical properties, while the network serves as cell entrapment system at...
Peripheral nerve injury (PNI) is a common and incurable disease in the clinic, but effects of available treatments are still not satisfactory. Therefore, it necessary to explore new treatment methods. To effect mechanism melatonin peripheral regeneration, we administered mice with PNI by intraperitoneal injection. We applied microarray analysis detect differentially expressed genes sciatic after application. Then, conducted gene ontology protein-protein interactions screen out key related...
Objective: The overall objective of this study was to investigate the effects catalpol on bone remodeling diabetic osteoporosis by regulating osteoblast differentiation and migration. Method: Using a murine model osteoporosis, detect protective loss, architectural deterioration trabecular metabolism biomarkers were tested. A MC3T3-E1 cells established treatment with high glucose; regulatory role in migration tested Western blot, ALP staining, Alizarin Red staining. Results: Catalpol markedly...
Osteoarthritis (OA) is a major health problem in the increasingly elderly population. Therefore, it crucial to prevent and treat OA at an early stage. The present study investigated whether pamidronate disodium (PAM), bone-loss inhibitor, can significantly or reverse progression of anterior cruciate ligament transection (ACLT)-induced OA. Whether therapeutic intervention associated with regulation expression osteoprotegerin (OPG), receptor activator nuclear factor-κB ligand (RANKL),...
Fractures are difficult to treat because of individual differences in bone morphology and fracture types. Compared serialized plates, the use customized plates significantly improves healing process. However, designing custom often requires extraction skeletal morphology, which is a complex time-consuming procedure. This study proposes method for extracting morphological features facilitate plate designs. The design involves three major steps: bone, representing undersurface plate,...
As a worldwide medical problem, spinal cord injury has no clear and effective treatment to improve its prognosis. Hence, new strategies for with good therapeutic efficacy have been actively pursued. drug loading system, acetal dextran nanoparticles (SAD) biocompatibility biodegradability. Therefore, we designed spermine-functionalized acetal-dextran encapsulated paclitaxel (PCL) into them. This design can ensure the sustained release of in injured area 4 days promote extension nerve processes