A5101818962- Diet and metabolism studies
- Pancreatic function and diabetes
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
- Regulation of Appetite and Obesity
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- COVID-19 Clinical Research Studies
- Ginseng Biological Effects and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Diabetes and associated disorders
- Lipid metabolism and disorders
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Intraperitoneal and Appendiceal Malignancies
- Bariatric Surgery and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
First Hospital of Jilin University
2014-2025
Jilin University
2014-2025
First Affiliated Hospital of Bengbu Medical College
2025
Nanjing Medical University
2024
Yanbian University
2019-2023
Guilin University of Electronic Technology
2023
Xuzhou Medical College
2014-2021
Yanbian University of Science and Technology
2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Cancer Research Center
2020
Tamoxifen is the gold standard for breast cancer endocrinotherapy. However, drug resistance remains a major limiting factor of tamoxifen treatment. Long non‑coding (lnc) RNA serves an important role in resistance; however, molecular mechanisms endocrinotherapy are largely unclear. lncRNA urothelial associated 1 (lncRNA UCA1, UCA1) has been proven to be dysregulated human and promotes progression. In present study, it was demonstrated that UCA1 significantly upregulated tissues compared with...
To investigate the risk factors for cognitive impairment in Chinese type 2 diabetes mellitus (T2DM) patients of advanced age and to identify effective biomarkers mild (MCI) these patients. T2DM (n = 120) aged 50-70 years were divided into groups with impaired (mild, moderate, severe) normal function based on Montreal Cognitive Assessment Mini-Mental State Examination scores. Data regarding demographic characteristics, clinical features diabetes, biochemical markers, metabolomics collected....
To investigate the effect of epigallocatechin gallate (EGCG) on structural changes gut microbiota in colorectal carcinogenesis.
Diabetes mellitus is considered as an important factor for cognitive decline and dementia in recent years. However, impairment diabetic patients often underestimated kept undiagnosed, leading to thousands of suffering from worsening memory. Available reviews this field were limited not comprehensive enough. Thus, the present review aimed summarize all available clinical studies on with decline, find valuable biomarkers that might be applied diagnostic therapeutic targets diabetes. The or...
Abstract: In recent years, obesity has become one of the major diseases that affect human health and consume resources, especially when it causes comorbidities such as hypertension, diabetes, cardiovascular disease kidney disease. Many studies have demonstrated is associated with development chronic can exacerbate progression end-stage renal This review described mechanisms obesity-associated nephropathy current relevant therapeutic modalities, aim finding new targets for nephropathy. The...
Objective: Ailanthone (AIL), a medicinal component with antitumor properties, was distilled from Ailanthus altissima . The aim of this work to probe the cancer-fighting effect AIL on bladder cancer (BC) cells and molecular basis effect. Material Methods: We developed subcutaneous BC mouse model then administered treatment. effects tumor tissue integrity apoptosis were analyzed using hematoxylin eosin (H&E) staining terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)...
Abstract Aims/Introduction The aims of the present study were to evaluate diagnostic value fasting plasma glucose, 2‐h postload glucose and glycosylated hemoglobin (HbA1c) measurements in screening diabetes prediabetes, determine cut‐off point HbA1c diagnosis prediabetes a Chinese population. Materials Methods A total 7,611 individuals aged 40 years or older, who did not have prior history diabetes, randomly selected Changchun area. For each participant, questionnaire was completed, physical...
Abstract Fatty acid synthase (FASN) is vital for maintaining lipid homeostasis in prostate cancer (PCa) cells, which have an increased rate of de novo fatty (FA) synthesis. Mutations the gene encoding tumor suppressor speckle‐type POZ protein (SPOP), a E3 ubiquitin ligase, are critical feature PCa. Here, we provide evidence that FASN substrate SPOP and interaction these proteins induces ubiquitination proteasome‐dependent degradation. We showed mutants commonly found PCa cannot bind to FASN....
Plague, a Yersinia pestis infection, is fatal disease with tremendous transmission capacity. However, the mechanism of how pathogen stays in reservoir, circulates and then re-emerges an enigma.We studied plague outbreak caused by construction large reservoir southwest China followed 16-years' surveillance.The results show prevalence within natural focus closely related to stability local ecology. Before during decade on Nanpan River, no confirmed has ever emerged. With impoundment...
Cholangiocarcinoma (CCA) is a malignant tumor that arises from the epithelial cells of bile duct and notorious for its poor prognosis. The clinical outcome remains disappointing, thus more effective therapeutic options are urgently required. Cordycepin, traditional Chinese medicine, provides multiple pharmacological strategies in antitumors, but mechanisms have not been fully elucidated. In this study, we reported cordycepin inhibited viability proliferation capacity CCA time- dose-dependent...
20(S)-Ginsenoside Rg3 (20(S)-Rg3) has been shown to induce apoptosis by interfering with several signaling pathways. Furthermore, it reported have anticancer and antidiabetic effects. In order detect the protective effect of 20(S)-Rg3 on diabetic kidney disease (DKD), rat models which were established administering high-sugar, high-fat diet combined intraperitoneal injection streptozotocin (STZ), age-matched wild-type (WT) given for 12 weeks, three groups: control group (normal adult rats...