A5102967945- Acute Myeloid Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- Insect and Arachnid Ecology and Behavior
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Insect Utilization and Effects
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- RNA modifications and cancer
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Renal cell carcinoma treatment
- Genomics and Phylogenetic Studies
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Reconstructive Surgery and Microvascular Techniques
- Refrigeration and Air Conditioning Technologies
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Immune cells in cancer
- Microbial Natural Products and Biosynthesis
Nanjing Medical University
2018-2025
University Medical Centre Mannheim
2019-2025
Heidelberg University
2019-2025
University Hospital Heidelberg
2019-2025
Jiangsu Cancer Hospital
2012-2025
Beijing Chao-Yang Hospital
2024-2025
Capital Medical University
2024-2025
Shanghai Ninth People's Hospital
2023-2025
Shanghai Jiao Tong University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Abstract Background Maize ( Zea mays L.) is one of the main agricultural crops with largest yield and acreage in world. However, maize germplasm very sensitive to low temperatures, mainly during germination, temperatures significantly affect plant growth crop yield. Therefore, identification genes capable increasing tolerance temperature has become necessary. Results In this study, fourteen phenotypic traits related seed germination were used assess genetic diversity through genome-wide...
Abstract Background Although the appearance of portal vein tumor thrombus (PVTT) is significantly associated with unfavorable prognosis, there insufficient evidence to confirm efficacy and safety triple combination transarterial chemoembolization (TACE), lenvatinib, programmed cell death‐1 (PD‐1) inhibitor for patients hepatocellular carcinoma (HCC) PVTT. Furthermore, it remains unclear which patient type can obtain best survival benefit from this therapy. Methods The data 160 HCC PVTT...
Abstract Background and Aim The study aims to investigate the efficacy safety of hepatic arterial infusion chemotherapy (HAIC) combined with lenvatinib immune checkpoint inhibitors (ICIs) versus ICIs for hepatocellular carcinoma (HCC) transarterial chemoembolization (TACE) refractoriness. Methods Patients intermediate or advanced TACE‐refractory HCC who received without HAIC between 2020 2022 were retrospectively reviewed. tumor response, overall survival (OS), progression‐free (PFS),...
The combination of regorafenib and immune checkpoint inhibitor (ICI) has been the most popular second-line systemic therapy for advanced hepatocellular carcinoma (HCC). However, considering good anti-tumor performance lenvatinib, combined immunotherapy on basis lenvatinib after first-line failure is also in clinical practice. This study aimed to compare efficacy safety plus ICI (TACE-R-I) versus (TACE-L-I) patients with HCC failure. In this single-center retrospective study, 164 were...
A heterodimer of two nuclear receptors, ecdysone receptor (EcR) and ultraspiracle, mediates 20-hydroxyecdysone (20E) signaling to modulate many aspects in insect life, such as molting metamorphosis, reproduction, diapause innate immunity. In the present paper, we intended determine isoform-specific roles EcR during larval-pupal-adult transition Colorado potato beetle. Double-stranded RNAs (dsRNAs) were prepared using common (dsEcR) or (dsEcRA, dsEcRB1) regions templates. Ingestion either...
Objective Camrelizumab is a newly developed program-death receptor one inhibitor; the real-world evidence about its application in hepatocellular carcinoma (HCC) treatment lacking. Therefore, this prospective, multi-center, study evaluated efficacy and safety of camrelizumab plus transarterial chemoembolization (TACE) treating intermediate-to-advanced HCC patients. Methods This consecutively enrolled 101 intermediate to advanced All patients received camrelizumab-based within 30 days...
Somatic mutations in genes coding for splicing factors, e.g. SF3B1, U2AF1, SRSF2, and others are found approximately 50% of patients with Myelodysplastic Syndromes (MDS). These have been predicted to frequently occur early the mutational hierarchy disease therefore making them particularly attractive potential therapeutic targets. Recent studies cell lines engineered carry factor revealed a strong association elevated levels DNA:RNA intermediates (R-loops) dependency on proper ATR function....
Background: The occurrence of necrotizing enterocolitis (NEC) is a common and severe disease the digestive system in neonates. This study aims to assess value intestinal tissue oxygen saturation (r int SO 2 ) combined with levels procalcitonin (PCT) mean platelet volume (MPV) predicting severity NEC preterm infants. Methods: experiment was retrospective cohort conducted Department Pediatrics, Hongqi Hospital Affiliated Mudanjiang Medical University between January 2017 July 2022. Premature...
The AML1-ETO fusion protein (A/E), which results from the t(8;21) translocation, is considered to be a leukemia-initiating event. Identifying mechanisms underlying oncogenic activity of A/E remains major challenge. In this study, we identified specific down-regulation brain acid-soluble 1 (BASP1) in acute myeloid leukemia (AML). recognized AML1-binding sites and recruited DNA methyltransferase 3a (DNMT3a) BASP1 promoter sequence, triggered methylation-mediated silencing BASP1. Ectopic...
Breast cancer is the most frequent malignant disease in women worldwide. It a heterogeneous and complex genetic with different molecular characteristics. MAPT-AS1, long non-coding RNA (lncRNA) existing at anti-sense strand of MAPT (microtubule associated protein tau) promoter region, was believed to regulate MAPT, which state Parkinson's disease. But role MAPT-AS1 breast has never been reported. In our study we found that overexpressed but not triple negative (TNBC), high expression...
Many animals exploit several niches sequentially during their life cycles, a fitness referred to as ontogenetic niche shift (ONS). To successfully accomplish ONS, transition between development stages is often coupled with changes in one or more primitive, instinctive behaviors. Yet, the underlining molecular mechanisms remain elusive. We show here that Leptinotarsa decemlineata larvae finish ONS at wandering stage by leaving plant and pupating soil. At middle phase, also switch phototactic...
Abstract The bone marrow (BM) stroma in myeloid neoplasms is altered and it hypothesized that this cell compartment may also harbor clonal somatically acquired mutations. By exome sequencing of vitro expanded mesenchymal stromal cells (MSCs) from n = 98 patients with myelodysplastic syndrome (MDS) 28 healthy controls we show these accumulate recurrent mutations genes such as ZFX (n 8/98), RANK 5/98), others. MDS derived MSCs display higher mutational burdens, increased replicative stress,...
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