A5101855003- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Chronic Kidney Disease and Diabetes
- Gastrointestinal motility and disorders
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Lymphatic System and Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Chromatin Remodeling and Cancer
- Acute Kidney Injury Research
- Inflammatory Biomarkers in Disease Prognosis
- Acute Ischemic Stroke Management
Harbin Medical University
2013-2024
Guangxi Medical University
2023
Southern Medical University
2012-2021
Sun Yat-sen University
2021
Beijing Jishuitan Hospital
2016
Peking University
2016
Nanfang Hospital
2012
Central South University
2012
China Medical University
2010
Abstract Protein degradation is essential for maintaining protein homeostasis. The ubiquitin‒proteasome system (UPS) and autophagy–lysosome are the two primary pathways responsible directly related to cell survival. In malignant tumors, UPS plays a critical role in managing excessive load caused by cancer cells hyperproliferation. this review, we provide comprehensive overview of dual roles played autolysosome colorectal (CRC), elucidating their impact on initiation progression disease while...
The DNA damage response (DDR) is one of the most important mechanisms platinum resistance in ovarian cancer. Some miRNAs have been identified to be involved regulatory network DDR, thus abnormal expression might affect chemosensitivity In this study, by assessing simultaneously targeting a set DDR genes that exhibited platinum, we found miR-211 inhibited those genes, and proposed sensitivity cancer cells multiple thereby determine prognosis To verify hypothesis, analyzed association between...
Abstract Colorectal cancer (CRC) is one of the most common malignant tumours, and its morbidity mortality rates are relatively high. However, aetiology pathogenesis CRC have not been clearly elucidated to date. AT-rich interaction domain 3A (ARID3A) a member ARID3 family transcription factor that can bind specific DNA sites regulate gene expression. It was reported ARID3A involved in various biological processes may be related carcinogenesis. In this study, by assessing mRNA level TCGA...
Abstract Background Environmental factors-induced dysfunction of esophageal squamous epithelium, including genomic DNA impairment and apoptosis, play an important role in the pathogenesis cell cancer. damage-induced 45α (GADD45α) has been found promoting repair removing methylation marker, Therefore, this study we will investigate whether GADD45α expression is induced its mechanism Methods Two human lines (ESCC), ECA109 KYSE510 were cultured RPMI-1640 medium supplemented with 10% fetal...
Many studies have provided valuable information about genomic and transcriptomic changes that occur in colorectal cancer. However, protein abundance cannot be reliably predicted by DNA alteration or mRNA expression, which can partially attributed to posttranscriptional and/or translational regulation of gene expression. In this study, we identified increased efficiency (TE) as a hallmark cancer evaluating the proteomic features patients with cancer, along comparative ribosome-protected...
Ovarian cancer is often accompanied by the production of ascites, and patients with repeated ascites are associated chemotherapy resistance. The previous study confirmed that ovarian who developed after had elevated autophagy levels in precipitated cells, which was positively correlated MDR1 expression blood patients.In order to explore correlation between chemoresistant, we searched TCGA GEO database analyze LC3B MDR1, identified targeting miRNA LC3B. It verified dual luciferase miR-204 can...
ARID3A is upregulated in colorectal cancer and can promote the proliferation metastasis of cells. However, patients with higher level have a better prognosis. This study aimed to uncover mechanism by which benefits prognosis colon cancer. Our results indicated that upregulation enhanced chemosensitivity cells 5-fluorouracil (5-FU), whereas downregulation inhibited 5-FU. Through database analysis, we found AKR1C3, drug resistance-related gene, was target ARID3A. Moreover, AKR1C3 downregulated...
Abstract As the major and preferred treatment for ovarian cancer ascites, chemotherapy can reduce or inhibit recurrent ascites (hereafter re-ascites); however, some patients still experience re-ascites. Therefore, this study investigated cases in which epithelial (EOC) experienced In re-ascites cases, CA125, MDR1, LC-3, Beclin-1 were highly expressed. addition, CASP-9 c-CASP-3 expression levels decreased, serum CA125 (highest 4348 U/ml) increased compared to chemosensitive cases. The results...
Breast cancer is a heterogeneous malignant disease with different prognoses and has been divided into four molecular subtypes. It believed that events occurring in breast stem/progenitor cells contribute to the carcinogenesis development of However, these subtype-specific characteristics are largely unknown. In this study, we employed 1217 samples from The Cancer Genome Atlas (TCGA) database for multiomics analysis subtypes based on PAM50 algorithms. We detected expression changes genes...
Intestinal dysmotility is a frequent complication during sepsis and plays an important role in the development of secondary infections multiple organ failure. However, central mechanisms underlying this process have not been well elucidated. Currently, effective therapies are still lacking for treatment sepsis-induced intestinal dysmotility. In study, we found that activation IL-17 signaling within muscularis propria might be associated with small intestine polymicrobial sepsis. Furthermore,...
Papillary thyroid cancer (PTC) is the most common type of malignancy, and it often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain‑containing 1 (EHD1) associated with EGFR‑mediated endocytotic recycling in multiple tumor types. The objective present study was determine protein expression levels clinical significance EHD1, EGFR, caveolin‑1 (CAV‑1) RAB11 family interacting 3 (RAB11FIP3) PTC. PTC specimens were analyzed for CAV‑1...
INTRODUCTION Cerebral fat embolism (CFE) is a rare but potentially lethal disease that usually complicated by long bone fracture, which can develop over 12–72 h. Since the main form of treatment for CFE supportive, early diagnosis, prevention, and appropriate reduce mortality development complications. However, due to symptom heterogeneity imprecise diagnostic methods, may be masked other clinical conditions make detection challenging. Given its low incidence, most studies are single cases...
IgA nephropathy (IgAN) is an immune complex glomerulonephritis that characterized by recurrent hematuria as the main clinical manifestation. In this study, we used IgAN mouse model which was previously established to investigate possible mechanism fibrosis correlates with decreased plasma gelsolin (pGSN) levels. We investigated levels of pGSN, transforming growth factor β1 (TGFβ1), and oxidative stress markers including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH),...
We report the crystal structures of enzyme GSDA in various forms at high resolutions, which reveal its recognition and catalytic mechanism may potentially aid development novel deaminase-based gene-editing tools.
<div>Abstract<p>Many studies have provided valuable information about genomic and transcriptomic changes that occur in colorectal cancer. However, protein abundance cannot be reliably predicted by DNA alteration or mRNA expression, which can partially attributed to posttranscriptional and/or translational regulation of gene expression. In this study, we identified increased efficiency (TE) as a hallmark cancer evaluating the proteomic features patients with cancer, along...
<p>Supplementary Figures</p>
<div>Abstract<p>Many studies have provided valuable information about genomic and transcriptomic changes that occur in colorectal cancer (CRC). However, protein abundance cannot be reliably predicted by DNA alteration or mRNA expression, which can partially attributed to post-transcriptional and/or translational regulation of gene expression. In this study, we identified increased efficiency (TE) as a hallmark CRC evaluating the proteomic features patients, along with comparative...
<p>Supplementary Figures</p>