A5101643720- Dental Implant Techniques and Outcomes
- Spine and Intervertebral Disc Pathology
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Bone Tissue Engineering Materials
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Musculoskeletal pain and rehabilitation
- Periodontal Regeneration and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Peptidase Inhibition and Analysis
- Intensive Care Unit Cognitive Disorders
- Fungal and yeast genetics research
- Phytochemical Studies and Bioactivities
- Veterinary Orthopedics and Neurology
- CNS Lymphoma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Inflammatory mediators and NSAID effects
- Tendon Structure and Treatment
- Acupuncture Treatment Research Studies
Harbin Medical University
2012-2024
Second Affiliated Hospital of Harbin Medical University
2002-2024
Health Sciences Centre
2018
University of Alberta
2018
Yunnan Agricultural University
2015
First Affiliated Hospital of Harbin Medical University
2006-2014
A prospective molecular mechanism of macrophages infiltration in experimental disc herniation.To investigate the mechanisms into dorsal root ganglion (DRG) a rat model herniation.Macrophages infiltrate DRG after application nucleus pulposus (NP) on DRG, and may play an important role radiculopathy. However, NP remain poorly understood.After herniation this study, we investigated changes expression ED1 (a marker macrophages) vascular cell adhesion molecule-1 (VCAM-1) using immunofluorescence....
Intestinal dysmotility is a frequent complication during sepsis and plays an important role in the development of secondary infections multiple organ failure. However, central mechanisms underlying this process have not been well elucidated. Currently, effective therapies are still lacking for treatment sepsis-induced intestinal dysmotility. In study, we found that activation IL-17 signaling within muscularis propria might be associated with small intestine polymicrobial sepsis. Furthermore,...
Focal adhesion kinase (FAK), a non-receptor tyrosine protein, acts as an early modulator of integrin signaling cascade, regulating basic cellular functions. In transformed cells, unopposed FAK has been considered to promote tumor growth, progression, and metastasis. The aim this study was assess the role focal in human osteosarcoma SAOS-2 cells. cells were transfected with PGPU6/GFP/shNC, PGPU6/GFP/FAK-334 (shRNA-334), respectively. Expression detected by real-time PCR western blots. MTT...
In Brief Study Design. Retrospective analysis. Objective. To determine the prognostic indicators in patients with solitary plasmacytoma of bone (SPB) spine. Summary Background Data. Population-level estimates for prognosis among SPB spine are still lacking. Sociodemographic and clinical predictors outcome have not been well characterized. Methods. The Surveillance, Epidemiology, End Results Registry was used to identify all from 1995 through 2014. Associated population data were annual...
Study Design. Retrospective analysis. Objective. To determine the prognostic indicators in patients with bone lymphoma of spine. Summary Background Data. date, prognosis for spinal is based on results from small series. Large population-based observational studies are lacking. Methods. The Surveillance, Epidemiology, and End Results Registry was used to identify all spine 1995 through 2014. Overall survival (OS) disease-specific (DSS) estimates were obtained using Kaplan-Meier method...
In Brief Study Design. Vaccination of spinal cord injury (SCI) mice with myelin basic protein-derived peptide (A91) pulsed dendritic cells (DC) to enhance brain-derived neurotrophic factor and neurotrophin-3 (NT-3) expression in injured cord. Objective. To investigate the effect A91-pulsed DC (A91-DC) on Summary Background Data. SCI leads progressive secondary tissue degeneration, no satisfactory treatment is currently available. Accumulating evidence indicates that administration factors...
With the emerging role of umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) for bone regeneration and delivery therapeutic proteins, there is an increasing need effective gene systems to modify such cells. mTAT, a TAT peptide sequence bearing histidine cysteine residues, has been successfully used intracellular delivery. Using gWiz-GFP plasmid, we demonstrated that polyethylenimine combined with mTAT (mTAT/PEI) displayed good transfection efficacy in hUCB-MSC. hUCB-MSC...
Background/Aims: Promyelocytic leukemia (PML) protein is a tumor suppressor that fuses with retinoic acid receptor-α (PML-RARα) to contribute the initiation of acute promyelocytic (APL). Arsenic trioxide (ATO) upregulates expression TGF-β1, promoting collagen synthesis in osteoblasts, and ATO binds directly PML induce oligomerization, sumoylation, ubiquitination. However, how TGF-β1 uncertain. Thus, we suggested sumoylation responsible for regulation expression. Methods: Kunming mice were...
The pathogenesis of osteoarthritis (OA) is still unclear, leading to the lack targeted treatment. We aimed probe into effect apolipoprotein D (APOD), key gene from our previous study through bioinformatics analysis, on fibroblast-like synoviocyte (FLS) and chondrocytes in vitro confirm its potential roles delay OA progression. Primary FLS were extracted synovium cartilage patients stimulated with interleukin 1β (IL-1β) vitro. After APOD intervention, viability proliferation detected....
The aim of the current study was to investigate prokaryotic expression Magnaporthe oryzae effector genes BAS1 and BAS4 fused fluorescent protein mCherry.Based on previous polymorphic analysis in rice blast strains using PCR, containing PCR products were selected for liquid culture total RNA extraction.For analysis, cDNA as a template amplify coding region BAS4, plasmid pXY201 mCherry sequence, three sequences cloned into pMD ® 19-T vectors.Positive recombinant plasmids digested two...