A5103146003- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- Mitochondrial Function and Pathology
- Bone Tissue Engineering Materials
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Stress Responses and Cortisol
- RNA modifications and cancer
- Circadian rhythm and melatonin
- Heart Rate Variability and Autonomic Control
- Ion Channels and Receptors
- Neuroscience and Neuropharmacology Research
- Remote-Sensing Image Classification
- Neuroendocrine regulation and behavior
- Cell death mechanisms and regulation
- Neuroscience of respiration and sleep
- Blood transfusion and management
- Neurotransmitter Receptor Influence on Behavior
- Medical Imaging Techniques and Applications
- Space Satellite Systems and Control
- Power Line Inspection Robots
- Bone Metabolism and Diseases
Sun Yat-sen University
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Harbin Medical University
2013-2023
Second Affiliated Hospital of Harbin Medical University
2014-2023
Nanjing University of Information Science and Technology
2022-2023
China National Petroleum Corporation (China)
2022
PetroChina Southwest Oil and Gas Field Company (China)
2022
Southwest Petroleum University
2022
Weatherford College
2020-2021
North China University of Water Resources and Electric Power
2021
Circular RNAs (circRNAs) play critical regulatory roles in cancer biological processes. Nevertheless, the contributions and underlying mechanisms of circRNAs to pancreatic ductal adenocarcinoma (PDAC) remain largely unexplored. Dysregulated between cancerous tissues matched adjacent normal were identified by circRNA microarray PDAC. The effect hsa_circ_007367 both vitro vivo was demonstrated gain- loss-of-function experiments. Further, dual-luciferase reporter RNA pull-down assays performed...
Abstract Infrared imagery surpasses the limitations of visible light images and finds widespread applications in fields such as military reconnaissance security surveillance. Recent studies on infrared target detection aim to preserve local features global representations greatest extent. However, compared images, exhibit inherent challenges insufficient texture information coarse boundaries, which introduce new difficulties this research. To address these issues, paper introduces additional...
Nodose ganglia are composed of A-, Ah-and C-type neurons.Despite their important roles in regulating visceral afferent function, including cardiovascular, pulmonary, and gastrointestinal homeostasis, information about subtype-specific expression, molecular identity, function individual ion transporting proteins is scarce.Although experiments utilizing the sliced ganglion preparation have provided valuable insights into electrophysiological properties nodose neuron subtypes, detailed...
It is important to perform contraband inspections on items before they are taken into public places in order ensure the safety of people and property. At present, mainstream method judging that security inspectors observe X-ray image objects judge whether belong contraband. Unfortunately, often hidden under other normal objects. In a high-intensity working environment, very prone missed detection wrong detection. To this end, framework based computer vision technology proposed, which trained...
Hyperpolarization-activated currents (Ih) mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels modulate excitability of myelinated A- and Ah-type visceral ganglion neurons (VGN). Whether alterations in Ih underlie the previously reported reduction VGNs following ovariectomy (OVX) has remained unclear. Here we used intact nodose preparation conjunction with electrophysiological approaches to examine role remodeling altering neuron adult rats. were identified based on...
Ischemia/reperfusion (I/R) injury of skeletal muscles is common pathophysiology during surgeries and the superoxide dismutase (SOD) plays a critical role in this process. SOD-modeled coordination compound (MSODa) may simulate protective effects as SOD.Therefore, study was designed to explore underlying mechanism MSODa on malondialdehyde (MDA) integrin-β2 (CD11b/CD18) plasma, myeloperoxidase (MPO) intercellular cell adhesion molecule-1 (ICAM-1) tissue, morphological changes before after I/R...
Evidence has shown gender differences regarding the critical roles of histamine in prevalence asthma, anaphylaxis, and angina pectoris.Histamine depolarizes unmyelinated C-type neurons without any effects on myelinated A-type vagal ganglion (VGNs) male rats.However, little is known if VGNs from females react to a similar manner.Membrane depolarization inward currents were tested isolated adult rats using whole-cell patch technique.Results males consistent with literature.Surprisingly,...
Cell disruption plays a vital role in detection of intracellular components which contain information about genetic and disease characteristics. In this paper, we demonstrate novel microfluidic platform based on an on-chip micropump for mechanical cell sample transport. A 50 μl can be effectively lysed through multi-disruption 36 s without introducing any chemical agent suffering from clogging by cellular debris. After 30 cycles circulating disruption, 80.6% 90.5% rates were achieved the...
A non-receptor protein kinase Src plays a crucial role in fundamental cell functions such as proliferation, migration, and differentiation. While inhibition of is reported to contribute chondrocyte homeostasis, its regulation at subcellular level by chemical inhibitors mechanical stimulation has not been fully understood. In response inflammatory cytokines stress the endoplasmic reticulum (ER) that increase proteolytic activities chondrocytes, we addressed two questions: Do interleukin 1...
Although autogenous bone grafts as well several graft substitute material have been used for some time, there is high demand more efficient and less costly bone-substitute materials. Silicon-substituted calcium phosphates (Si-CaP) fine particulate powder (FPBP) preparations previously shown to individually possess many of the required features a scaffold. However, when applied individually, these two materials fall short an ideal material. We investigated new concept combining Si-CaP with...
Autogenous bone graft is the best for spinal fusion in clinics, however, lacking sources, bleeding and infection are limited its practice. Seeking alternative materials urgent orthopaedic surgeon. Here, we evaluated osteoblast-oriented differentiation of rabbit BMSCs by co-culturing with composite scaffolds constructed using silicon-substituted-CaP-fine particulate powder-alginate. Using CCk8-kit, biocompatibility was testing proliferation; morphology survival osteoblasts within were...
Abstract Aim To study the dominant role of parasympathetic inputs at cellular level baroreflex afferent pathway and underlying mechanism in neurocontrol blood pressure regulation. Methods Whole‐cell patch‐clamp animal were conducted. Results For first time, we demonstrated spontaneous activities from resting membrane potential myelinated A‐ Ah‐type baroreceptor neurons (BRNs, 1st‐order), but not unmyelinated C‐types, using vagus‐nodose slice adult female rats. These data further supported by...
Background/Aims: Promyelocytic leukemia (PML) protein is a tumor suppressor that fuses with retinoic acid receptor-α (PML-RARα) to contribute the initiation of acute promyelocytic (APL). Arsenic trioxide (ATO) upregulates expression TGF-β1, promoting collagen synthesis in osteoblasts, and ATO binds directly PML induce oligomerization, sumoylation, ubiquitination. However, how TGF-β1 uncertain. Thus, we suggested sumoylation responsible for regulation expression. Methods: Kunming mice were...
Abstract Pancreatic cancer (PC) is mainly derived from the exocrine pancreatic ductal epithelial cells, and it strongly aggressive malignant tumor. Due to its insidious onset lack of effective diagnostic biomarkers, PC currently remains one main causes cancer-related mortality worldwide. Recent studies have found that hsa_circ_0001846 involved in progression multiple cancers has potential become but function mechanism unclear. We by qRT-PCR experiments was upregulated cells tissues, while...
Objective: This study aimed to investigate how early A-waves could occur in type II diabetes, and what it implied functionally. Methods: We performed conduction velocity distribution (CVD) test peroneal nerves of 37 diabetic patients with normal nerve (NCS) 22 age-matched controls. The electrophysiological data clinical information were analyzed. Results: observed 45.9% only 1 person healthy controls, all detected the tibial nerves. showed faster quartiles motor compared without A-waves,...
Value and correlation analysis between ultrasound mammography in the diagnosis other risk factors related to breast cancer were explored. A total of 1,473 patients who underwent color ultrasonography molybdenum target X-ray examination Binzhou Medical University Hospital from March 2017 August 2018 collected, patient's results compared, also pathological biopsy was used as reference golden criteria calculate value both test methods combined cancer. The associated with analyzed. Among...
Nowadays, the gas chromatography (GC) method is vastly used in natural energy measurement but suffers from slow analysis, high capital investment, and maintenance costs. With advent of commercial calorimeters using new principles, calorimeter (CM) has ability to overcome shortcomings GC hoping be an alternative for measurement. To realize accurate metering by CM method, standard GERG-88 viral equation (denote hereafter as SGERG-88 algorithm) needed calculate compressibility factors...