A5062120072- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Enzyme function and inhibition
- RNA Research and Splicing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Lubricants and Their Additives
- Acupuncture Treatment Research Studies
- Central Venous Catheters and Hemodialysis
- Sperm and Testicular Function
- Atrial Fibrillation Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Endoplasmic Reticulum Stress and Disease
- Plant Molecular Biology Research
- Genomics and Chromatin Dynamics
- Plant Reproductive Biology
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Tribology and Wear Analysis
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
Yangzhou University
2020-2023
Anhui University of Science and Technology
2018
Chinese Academy of Sciences
2016-2017
Institute of Zoology
2016-2017
Southern Medical University
2016
Anhui University
2012
Significance The major spliceosome is required for mRNA processing and believed to be essential cell survival. Here we report that mutations affecting the are associated with nonobstructive azoospermia (NOA), a common but poorly understood cause of male infertility in humans. Specifically, dysregulation impairs differentiation spermatogonia, abolishing maturation germ cells into sperm. requirement during spermatogonial highly conserved among species. Our study has uncovered genetic causes...
Hepatocellular carcinoma (HCC) is one of the most common types cancer worldwide and its incidence continues to increase year by year. Endoplasmic reticulum stress (ERS) caused protein misfolding within secretory pathway in cells has an extensive deep impact on cell progression survival. Growing evidence suggests that genes related ERS are closely associated with occurrence HCC. This study aimed identify ERS-related signature for prospective evaluation prognosis HCC patients. RNA sequencing...
The fluctuating CDK-CYCLIN complex plays a general role in cell-cycle control. Many types of stem cells use unique features the cell cycle to facilitate asymmetric division. However, manner which these are established remains poorly understood. Drosophila female germline (GSCs) is characterized by short G1 and very long G2 phases, making it an excellent model for study control fate determination. Using GSC model, we found Gcn5, first discovered histone acetyltransferase, maintain ovaries....
Abstract Plastin‐3 plays a key role in cancer cell proliferation and invasion, but its prognostic value pancreatic (PACA) remains poorly defined. In this study, we show that PLS3 messenger RNA is overexpressed PACA tissue compared with normal tissue. We accumulated 207 cases of specimens to perform immunohistochemical analysis demonstrated levels correlate T‐classification ( p < .001) pathology .001). Furthermore, overall survival rates tumors high expression were poor, as assessed...
Due to the difficulties in early diagnosis of pancreatic adenocarcinoma (PAAD), many patients fail receive optimal therapeutic regimens. The Secretory-Carrier-Membrane-Proteins (SCAMPs) are known be dysregulated a range human diseases due their characterized roles mammalian cell exocytosis inferred from functions as integral membrane proteins. However, expression and prognostic value SCAMPs PAAD is poorly characterized. We compared cancer vs. healthy tissue found that SCAMPs1-4 was...
COL17A1 (collagen type XVII alpha 1 chain) is known to be upregulated and has a prognostic role in many malignancies, as well contributing cell proliferation, apoptosis, invasion. However, little knowledge available on the expression value of pancreatic adenocarcinoma (PDAC). In our study, we searched public database found that mRNA protein levels are commonly PDAC tissues. The immunohistochemical analysis conducted by us revealed enhanced 169 samples compared with 67 adjacent normal We also...
In order to improve the friction and wear performance of textured port plate pair, effects micropit depth on tribology is studied in paper. The relation between pair’s oil loading carrying capacity analyzed theory; with coefficient, volume surface roughness as evaluation criteria, micropits’ are investigated. conclusions shown follows: would come its peak when film thickness equal depth; optimal unrelated area ratios diameters. With same parameters, antifriction 10 μ m, while antiwear...
Background. Circulating plasma mRNAs can be analyzed to identify putative cancer biomarkers. This study was conducted in an effort detect mRNA biomarkers capable of predicting pancreatic (PACA) patient prognosis. Material and Methods. First, prognostic that were differentially expressed PACA The Cancer Genome Atlas (TCGA) established, after which microarray expression profiles from samples utilized specifically potential associated with this type. In total, then collected 79 patients 19...
A pair of degenerate primers was designed according to the conservative regions at 3' terminus floral meristem identity genes (LEAFY). 361 bp cDNA fragment LEAFY homologous gene (PcBLFY) coding for 120 amino acid residues amplified via RT-PCR from flower buds male, female and hermaphrodite plant Pistacia chinensis Bunge respectively. Furthermore, 989 genomic PcBLFY isolated by homology cloning strategy. Sequence analysis indicated that this contained a 628 intron splicing sites were similar...
When the skin barrier is damaged, surgical dressings are often used to cover wounds, sustain barrier, protect injured area, prevent bacterial infection, and promote wound healing. However, at present, traditional will be come stiffing as it absorbs exudates of sometimes cause secondary injury during application process, which aggravate pain patients without analgesic effect. For this reason, medical staff from Northern Jiangsu People's Hospital designed a new antibacterial dressing that can...