A5100448584- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related gene regulation
- Asthma and respiratory diseases
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Respiratory Support and Mechanisms
- Endometrial and Cervical Cancer Treatments
- Pregnancy-related medical research
- Extracellular vesicles in disease
- Acute Ischemic Stroke Management
- Sulfur Compounds in Biology
- Caveolin-1 and cellular processes
- Mangiferin and Mango Extracts
- Birth, Development, and Health
- Sirtuins and Resveratrol in Medicine
- Medicinal Plants and Bioactive Compounds
Hospital of Hebei Province
2024
Zhujiang Hospital
2017-2024
Qinzhou Maternity and Child Health Care Hospital
2024
Southern Medical University
2017-2024
Peking University People's Hospital
2024
Peking University
2024
Guangdong Pharmaceutical University
2024
Qilu Hospital of Shandong University
2012-2023
Chinese PLA General Hospital
2023
Hebei North University
2023
Recently, circular RNAs (circRNAs) have been reported to be microRNA sponges and play essential roles in cancer development. This study aimed evaluate whether circulating circRNAs could used as diagnostic biomarkers for lung adenocarcinoma (LUAD). The Gene Expression Omnibus (GEO) dataset was investigate differentially expressed (DEcircRNAs) paired LUAD tissues adjacent nontumor tissues. expression levels of the host genes were analyzed Cancer Genome Atlas (TCGA)-LUAD dataset, prognostic...
Abstract Background Long non-coding RNAs (lncRNAs) are increasingly recognized as the crucial mediators in regulation of ferroptosis and iron metabolism. A systematic understanding iron-metabolism related lncRNAs (FIRLs) lung adenocarcinoma (LUAD) is essential for new diagnostic therapeutic strategies. Methods FIRLs were obtained through Pearson correlation analysis between genes all lncRNAs. Univariate multivariate Cox regression used to identify optimal prognostic Next, a novel signature...
Abstract Background DNA methylation can regulate the role of long noncoding RNAs (lncRNAs) in development lung adenocarcinoma (LUAD). The present study aimed to identify methylation-driven lncRNAs and mRNAs as biomarkers prognosis LUAD using bioinformatics analysis. Methods Differentially expressed were obtained edge R package from 535 tissues 59 adjacent non-LUAD tissues. methylated genes limma 475 32 Methylation-driven mRNA lncRNA MethylMix 465 with matched RNA expression methylation. Gene...
Background: Ovarian cancer is the most lethal female genital malignancy. Although cisplatin first-line chemotherapy to treat ovarian patients along with debulking surgeries, its efficacy limited due high incidence of resistance. ATP citrate lyase (ACLY) has been shown be a key metabolic enzyme and associated poor prognosis in various cancers, including cancer. Nevertheless, no studies have probed mechanistic relationship between ACLY Methods: Survival analysis was mainly carried out online....
Chronic obstructive pulmonary disease is a kind of chronic lung characterized by persistent air flow obstruction, which was the third leading cause death in China. The incidence COPD steadily and increasing has been globally sever disease. Accordingly, it urgently needed to explore how diagnose treat timely. This study aims find key genes as soon possible avoid processing analyze immune cell infiltration between early stage late stage. Two GEO datasets were merged merge data for analyses....
Objectives MicroRNA-7 (miR-7) is highly connected to cancerous cell proliferation and metastasis. It also involved in myocardial ischemia-reperfusion (I/R) injury upregulated cardiomyocyte under simulated I/R (SI/R). We aimed investigate the role of miR-7 during vitro vivo a possible gene target. Methods Results Real-time PCR revealed that miR-7a/b expression was H9c2 cells after SI/R. Flow cytometry showed SI/R-induced apoptosis decreased with mimic transfection but increased inhibitor...
BACKGROUND:Hypoxia induces cell apoptosis in the uterosacral ligaments of patients with pelvic organ prolapse by upregulation hypoxia-inducible factor-1α (HIF-1α). This study aimed to investigate effects HIF-1α on human ligament fibroblasts (hUSLFs) following treatment chemical inducer hypoxia, cobalt chloride (CoCl2), and explore underlying mechanisms. MATERIAL AND METHODS:Ten women who underwent hysterectomy for benign disease provided tissue extraction. Following CoCl₂ treatment,...
N6-methyladenosine RNA modification plays a significant role in the progression of multiple tumorigenesis. Our study identified imperative m6A regulators tumor immune microenvironment, survival, stemness score, and anticancer drug sensitivity pan-cancer. The Wilcox test was to identify differential expression between 17 across 33 TCGA cancer types their normal tissues from UCSC Xena GDC Survival analysis m6A-related using “survival” “survminer” package. Spearman correlation Pearson were used...
Lung cancer is the leading cause of cancer-related mortality worldwide, and non-small cell lung (NSCLC) accounts for over 80% all cancers. Serum microRNAs (miRNAs), due to their high stability, have potential become valuable noninvasive biomarkers. This present study was aimed identify serum miRNAs expression signatures diagnosis prognosis NSCLC using bioinformatics analysis.A total 12 profiling studies been identified in Pubmed, Gene Expression Omnibus (GEO), ArreyExpress databases....
Background Vascular calcification and increased cardiovascular morbidity mortality are closely related in patients with end‐stage renal disease diabetes mellitus. Specific protein 1 (Sp1) is a transactivation molecule that plays crucial role the regulation of apoptosis, fibrosis, angiogenesis, other pathological disorders. There evidence specific directly stimulates transcription bone morphogenetic 2 ( BMP 2) key process 2–expressing F9 cell model system. Here, we investigated whether Sp1 an...
Background: Cycle ergometer training (CET) has been shown to improve exercise performance of the quadriceps muscles in patients with COPD, and inspiratory muscle (IMT) may pressure-generating capacity muscles. However, effects combined CET IMT remain unclear there is a lack comprehensive assessment. Materials methods: Eighty-one COPD were randomly allocated three groups: 28 received 8 weeks + (combined group), 27 alone (CET 26 only free walking (control group). Comprehensive assessment...
Immune-related genes (IRGs) play considerable roles in tumor immune microenvironment (IME). This research aimed to discover the differentially expressed immune-related (DEIRGs) based on Cox predictive model predict survival for lung squamous cell carcinoma (LUSC) through bioinformatics analysis. First of all, (DEGs) were acquired The Cancer Genome Atlas (TCGA) using limma R package, DEIRGs obtained from ImmPort database, whereas transcription factors (DETFs) Cistrome database. Thereafter, a...
Abstract Background Lung adenocarcinoma (LUAD) is a heavy social burden worldwide. Because the mechanisms involved in LUAD remain unclear, prognosis of remains poor. Consequently, it urgent to investigate potential LUAD. Junctional adhesion molecule-like protein (JAML), recognized as tumorigenesis molecule gastric cancer. However, role JAML still unclear. Here we aimed evaluate Methods qRT-PCR, Western blotting and immunohistochemistry were conducted expression tissues. was knocked down...
Non-small cell lung cancer (NSCLC) is currently a problem in the clinic and society. Tumor-related macrophages (TAMs) tumor microenvironment (TME) play vital role development of NSCLC.Bioinformatics was used to analyze Indoleamine 2,3-dioxygenase 1 (IDO1) NSCLC correlation its expression with CD163 expression. The IDO1 measured by immunohistochemistry, their colocalization assessed immunofluorescence. M2 macrophage polarization induced, coculture model cells established.Bioinformatics...
Epithelial ovarian cancer (EOC) is the most lethal in female genital tumors. New disease markers and novel therapeutic strategies are urgent to identify considering current status of treatment. Receptor tyrosine kinases family plays critical roles embryo development progression. However, ambivalent research conclusions ROR2 make its role tumor confused underlying mechanism far from being understood. In this study, we sought clarify effects on high-grade serous carcinoma (HGSOC) cells reveal...
Background: DNA methylation acts as a key component in epigenetic modifications of genomic function and functions disease-specific prognostic biomarkers for lung squamous cell carcinoma (LUSC).This present study aimed to identify methylation-driven genes LUSC using bioinformatics analysis.Materials Methods: Differentially expressed RNAs were obtained the edge R package from 502 tissues 49 adjacent non-LUSC tissues.Differentially methylated limma 504 69 tissues.The MethylMix 500 with matched...