A5102984297- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Horticultural and Viticultural Research
- Genetic diversity and population structure
- Vasculitis and related conditions
- Plant Physiology and Cultivation Studies
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Bacterial biofilms and quorum sensing
- Cancer, Lipids, and Metabolism
- Plant Pathogens and Fungal Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Antimicrobial Resistance in Staphylococcus
- Plant Gene Expression Analysis
- Mycobacterium research and diagnosis
- Plant Disease Resistance and Genetics
- Urticaria and Related Conditions
- Chronic Kidney Disease and Diabetes
- Effects of Vibration on Health
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
- Renal Diseases and Glomerulopathies
- Antimicrobial Peptides and Activities
- Cancer, Hypoxia, and Metabolism
First Hospital of China Medical University
2018-2025
South China Normal University
2025
China Medical University
2010-2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Dalhousie University
2021-2024
First Affiliated Hospital Zhejiang University
2024
Institute of Pomology
2017-2023
Capital Institute of Pediatrics
2023
Izaak Walton Killam Health Centre
2021-2022
ABSTRACT We have previously shown that a thickened cell wall is responsible for the vancomycin resistance of vancomycin-resistant Staphylococcus aureus (VRSA) (equivalent to vancomycin-intermediate S. and glycopeptide-intermediate ) strain Mu50 (L. Cui, H. Murakami, K. Kuwahara-Arai, Hanaki, Hiramatsu, Antimicrob. Agents Chemother. 44:2276-2285, 2000). However, mechanism in other VRSA strains remained unclear. In this study, 16 clinical from seven countries were subjected serial daily...
The purpose of this study was to elucidate the mechanism action baricitinib on JAK/STAT signaling, which involves in human innate and adaptive immune system. effects were evaluated using monocyte-derived dendritic cells (MoDCs), plasmacytoid (pDCs), B T cells. Baricitinib concentration-dependently suppressed expression CD80/CD86 MoDCs production type-I IFN by pDCs. also differentiation into plasmablasts cell receptor stimuli, inhibited IL-6 from Human CD4+ proliferated after stimulation with...
T follicular helper (Tfh) cells are critical in the development and progression of systemic lupus erythematosus (SLE). To assess characteristics mechanisms differentiation Tfh cells, we investigated phenotype patients with SLE underlying epigenetic modifications by cytokine-induced signal transducer activators transcription (STAT) family factors.Peripheral blood mononuclear from healthy donors were analysed flow cytometry. CD4+ isolated cultured under various stimulations. Expression...
T helper (Th) cells can differentiate into functionally distinct subsets and play a pivotal role in inflammatory autoimmune diseases such as rheumatoid arthritis (RA). Th22 have been identified new subset secreting interleukin (IL)-22. Although elevated levels of IL-22 the synovial fluids RA patients were reported, its pathological roles remain unclear. Here, we demonstrated that was characteristically produced from CD3+CD4+CC-chemokine receptor (CCR)4+CCR6+CCR10+ their ability production...
Background: Ovarian cancer is the most lethal female genital malignancy. Although cisplatin first-line chemotherapy to treat ovarian patients along with debulking surgeries, its efficacy limited due high incidence of resistance. ATP citrate lyase (ACLY) has been shown be a key metabolic enzyme and associated poor prognosis in various cancers, including cancer. Nevertheless, no studies have probed mechanistic relationship between ACLY Methods: Survival analysis was mainly carried out online....
Abstract The genetic diversity of germplasm is critical for exploring and phenotypic resources has important implications crop-breeding sustainability improvement. However, little known about the factors that shape maintain diversity. Here, we assembled a high-quality chromosome-level reference Chinese common apricot ‘Yinxiangbai’, resequenced 180 accessions cover four major ecogeographical groups in China other from occidental countries. We concluded Chinese-cultivated germplasms possessed...
Chronic kidney disease (CKD) is characterized by high morbidity and mortality difficult to cure. Renal interstitial fibrosis (RIF) a major determinant of, commonly occurs within, CKD progression. Epithelial mesenchymal transition (EMT) has been identified as crucial process in triggering renal (RIF). Interleukin-like EMT inducer (ILEI) an important promotor of EMT; this study aims elucidate the mechanisms involved.Male C57BL6/J mouse were randomly divided into 6 groups: sham (n = 10), with...
Exposure to environmental noise is an inevitable factor and may pose a risk health conditions, even potentially affecting the immune system. However, relationship between exposure autoimmune diseases has not been well explored. This study aimed investigate whether associated with increased of in South Korea. We analyzed data from National Health Insurance Service (NHIS) cohort 2013 2019. Environmental were provided by Noise Information System (NNIS) spatially interpolated using empirical...
Abstract Chinese plum ( Prunus salicina L.), also known as Japanese plum, is gaining importance because of its extensive genetic diversity and nutritional attributes that are beneficial for human health. Single-nucleotide polymorphisms (SNPs) the most abundant form genomic widely used in population genetics research. In this study, we constructed high-quality SNPs through whole-genome resequencing 67 accessions with a depth ~20× to evaluate genome-level structure. Phylogenetic analysis,...
Abstract Objective Peripheral helper T (Tph) cells interact with B and promote immune responses at sites of ectopic lymphoid structures (ELSs). To assess the characteristics Tph cells, we investigated phenotype (Th) in patients SLE underlying competitive binding mechanisms using cytokine-mediated signal transducer activator transcription (STAT) factors. Methods blood mononuclear from healthy controls were analysed for phenotypic identification. Serum cytokine levels detected Luminex assays....
Improving fruit quality is one of the main tasks in modern commercial apricot breeding. Because lack high-density linkage maps and fine mapping, it difficult to obtain molecular markers that can assist breeding for quantitative inheritance traits. In this study, specific-locus amplified fragment sequencing was used genotype 169 seedlings F1 (Prunus armeniaca L.) progenies derived from crossing "Chuanzhihong" (H) with "Saimaiti" (S). After aligning Prunus reference genome filtering out...
Background IgAV, the most common systemic vasculitis in childhood, is an immunoglobulin A-associated immune complex-mediated disease and its underlying molecular mechanisms are not fully understood. This study attempted to identify differentially expressed genes (DEGs) find dysregulated cell types IgAV pathogenesis for IgAVN. Methods GSE102114 datasets were obtained from Gene Expression Omnibus (GEO) database DEGs. Then, protein-protein interaction (PPI) network of DEGs was constructed using...
The etiology of autoimmune disease pathogeneses remains obscure, and the impact general environmental or occupational exposure to external airborne agents (EAA) on diseases understudied. This study was conducted elucidate association between EAA risk according type. From NHIS-NSC (2002-2019), 17,984,963 person-years were included in data analysis. Autoimmune categorized based InterLymph classification. We estimated incidence rate ratio exposure. Association investigated using logistic...
Abstract Objectives T peripheral helper (Tph) cells have major roles in pathological processes SLE. We sought to clarify the mechanisms of Tph cell differentiation and their relevance clinical features patients with Method Phenotypes functions cell-related markers human CD4+ purified from volunteers or were analysed using flow cytometry quantitative PCR. Renal biopsy specimens LN probed by multicolour immunofluorescence staining. Results Among multiple cytokines, transforming growth factor...
Abstract Objectives The induction direction of interferon (IFN)-α in T-cell phenotype and function varies depending on the activation state cell time stimulation. To assess effects elevated IFN-α regulatory T cells (Tregs) systemic lupus erythematosus (SLE) patients, we investigated differentiation Th1-like Tregs under in-sequence out-of-sequence conditions reversal effect activating TIGIT immune suppression. Methods Phenotypes levels from SLE patients healthy controls were analyzed using...