A5049023406- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Synthesis and biological activity
- Ubiquitin and proteasome pathways
- Synthesis and Biological Evaluation
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Intraocular Surgery and Lenses
- Congenital Diaphragmatic Hernia Studies
- Nausea and vomiting management
- Spine and Intervertebral Disc Pathology
- Cancer therapeutics and mechanisms
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Maternal and fetal healthcare
- Ocular Surface and Contact Lens
- Maternal and Perinatal Health Interventions
- Protein Degradation and Inhibitors
- Corneal Surgery and Treatments
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Neurosurgical Procedures and Complications
- Dialysis and Renal Disease Management
- Tracheal and airway disorders
Sichuan University
2009-2025
West China Second University Hospital of Sichuan University
2015-2025
Zhejiang Chinese Medical University
2025
First Hospital of China Medical University
2007-2024
First Affiliated Hospital of Wannan Medical College
2023
Tongji Hospital
2022
Hubei Provincial Women and Children's Hospital
2021
Creative Commons
2018-2020
China Medical University
2007-2019
Guangdong Provincial People's Hospital
2019
Abstract More than 14,000 people die from invasive transitional cell carcinoma (TCC) of the urinary bladder yearly in United States. Cyclooxygenase (COX)-inhibiting drugs are emerging as potential antitumor agents TCC. The optimal vitro or vivo systems to investigate COX inhibitor effects have not been defined. purpose this study was determine COX-1 and COX-2 expression inhibitors human TCC lines (HT1376, RT4, UMUC3 cells) xenografts derived those lines. (Western blot, immunocytochemistry)...
Androgenetic alopecia (AGA) is a type of hair loss. Our previous study showed AGA ameliorating capability water extract an herbal prescription, "Jiawei Erzhiwan" (WJWE), which was derived from the traditional formula "Erzhiwan". However, underlying mechanisms still unknown. In this study, phytochemical ingredients in WJWE were characterized via UPLC‒MS/MS analysis. The dihydrotestosterone (DHT)-induced murine model and dermal papilla cells (DPCs) assays used to evaluate elucidate beneficial...
Tracheobronchial foreign body aspiration in children is a life-threatening, emergent situation. Currently, the use of fiberoptic bronchoscopy for removing bodies attracting increasing attention. Oxygen desaturation, movement, laryngospasm, bronchospasm, and breath-holding are common adverse events during removal. Dexmedetomidine, as highly selective α2-adrenergic agonist, produces sedative analgesic effects, does not induce respiratory depression. We hypothesized that intranasal...
Epithelial-mesenchymal transition (EMT) has been recognized to accelerate peritoneal membrane dysfunction. 1,25(OH)2D3/vitamin D receptor (VDR) is important for preventing various types of EMT in vivo. However, its function on and inflammation human mesothelial cells (HPMCs) remains be elucidated. Therefore, the present study investigated effects 1,25(OH)2D3/VDR high glucose (HG)‑induced HPMCs underlying molecular mechanism. It was determined that HG reduced VDR expression, increased...
The regulation of cell proliferation, differentiation and immunomodulation are affected by 1,25(OH)2D3. However, its function during apoptosis oxidative stress in human peritoneal mesothelial cells (HPMCs) remains unknown. aim the present study was to investigate whether have therapeutic relevance dialysis (PD) therapy. investigated effects 1,25(OH)2D3 on high glucose (HG)-induced reactive oxygen species (ROS) production HPMCs, examined underlying molecular mechanisms. Flow cytometry western...
To elucidate the immunomodulatory mechanisms of macrolides, we investigated here effects erythromycin (EM) and its derivatives, 1 2, which show no antibacterial activity, on proliferation activation transcription factor nuclear factor-kappaB (NF-kappaB) in Jurkat T cells. MTT assay revealed that EM, 2 could inhibit lymphocyte markedly. Flow cytometry TUNEL analysis showed EM (30 microg/mL-100 microg/mL) (3 microg/mL-30 induce apoptosis, induced a cell cycle arrest G(2)/M. RT-PCR Western...
Abstract The cognitive dysfunction caused by prediabetes causes great difficulties in human life, and the terrible thing is that means to prevent occurrence of this disease are very limited at present, Berberine has shown potential treat diabetes dysfunction, but it still needs be further explored clarify mechanism its therapeutic effect. Therefore, aim study was investigate effects mechanisms on prediabetes‐induced dysfunction. Prediabetes rat model induced a high‐fat diet normal used as...
Introduction: Splenic ectopic pregnancy (SEP), a special abdominal pregnancy, is extremely rare but carries high risk of potentially uncontrollable, life-threatening intraperitoneal bleeding at early gestation, which equivalent to the spontaneous rupture spleen. Therefore, diagnosis SEP crucial and may avoid situation. Case presentation: A 29-year-old G3P2 woman presented with 50 days amenorrhea positive serum β-human gonadotropin (β-HCG) was enrolled into hospital due absence gestational...
Abstract The common tokay gecko ( G ekko ) is widely distributed across southern C hina, V ietnam and other countries in S outheast A sia. It includes two distinct morphological forms with largely allopatric distributions, which are referred to as the black‐spotted red‐spotted tokay. Considering their different features a question has been proposed by taxonomists still not resolved: do these belong one subspecies? Previous studies indicated high genetic variability between them, but did give...
Atorvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitor and inhibits cholesterol synthesis. Recently, atorvastatin also showed anti-inflammatory effect in acute lung injury, ameliorating pulmonary gas-blood exchanging function. Sphingosine kinase 1 plays central role endothelial (EC) cytoskeleton rearrangement EC barrier integrity regulation. In this study, the of sphingosine against injury was investigated. Both wild-type (WT) SphK1-/- mice were...
Mouse double minute 2 homolog (MDM2) binds to p53 through the 1-52 amino acid region of p53, in order ubiquitinate p53. MDM2 thus destabilises and inhibits effect on cell cycle arrest apoptosis. In present study, wild-type (wt) protein was stably expressed H1299 cells. The lysate transfected cells then analysed using co-immunoprecipitation. A specific fraction precipitate subjected mass spectrometry analysis, which revealed that bound inhibitor activated STAT3 (PIAS3). To best our knowledge,...
Anesthetic management of patients with preexisting diseases is challenging and individualized approaches need to be determined based on patients' complications. We report here a case ultrasound-guided epidural anesthesia in combination low-dose ketamine during cesarean delivery parturient severe malformations the skeletal system airway problems. The was performed L1-L2 space, followed by an intravenous administration (0.5 mg/kg) for sedation analgesia. Satisfactory provided patient...
Cancer cells differ from normal body in their ability to divide indefinitely and evade programmed cell death. Crosstalk between apoptosis cycle processes promotes balance proliferation death, limits population growth survival of cells. However, intricate relationships them how they are able manipulate the fate cancer still remain be clarified. Identification key factors involved both regulation may help address this problem.Identification such proteins was carried out, using a series...