A5048447893- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Gallbladder and Bile Duct Disorders
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Esophageal and GI Pathology
- Hepatitis B Virus Studies
- Cancer Research and Treatments
- Gastrointestinal disorders and treatments
- Microtubule and mitosis dynamics
- Pediatric Hepatobiliary Diseases and Treatments
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Tryptophan and brain disorders
- Kawasaki Disease and Coronary Complications
- Liver Disease Diagnosis and Treatment
Nankai University
2015-2025
Liaocheng People's Hospital
2025
Henan Provincial People's Hospital
2023-2025
China Medical University
2024
First Hospital of China Medical University
2024
Tianjin Medical University General Hospital
2024
Kunming Medical University
2013-2023
Huazhong University of Science and Technology
2017-2023
Central Hospital of Wuhan
2014-2023
Zhengzhou People's Hospital
2023
Abstract Immunotherapy for cancer treatment is achieved through the activation of competent immune effector cells and inhibition immunosuppressive cells, such as myeloid-derived suppressor (MDSCs). Although MDSCs have been shown to contribute breast development, mechanism underlying MDSC-mediated immunosuppression unclear. We identified a poorly differentiated MDSC subset in cancer–suppressing T cell function STAT3-dependent IDO upregulation. In this study we investigated mechanisms aberrant...
// Tiansuo Zhao 1,* , He Ren Li Jia 2 Jing Chen 1 Wen Xin Fan Yan Xiuchao Wang Song Gao Dong Qian Chongbiao Huang and Jihui Hao Tianjin Medical University Cancer Institute Hospital, National Clinical Research Center for Cancer, Key Laboratory of Prevention Therapy, Department Pancreatic Tianjin, China Centre Haemato-Oncology, Barts Institute, Queen Mary London, UK * These authors contributed equally to this work Correspondence: Hao, email: Keywords : ductal adenocarcinoma (PDAC), Immunogenic...
A series of novel, highly potent, selective inhibitors targeting both CDK4/9 and HDAC1 have been designed synthesized. N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d] pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide (6e) was discovered. The lead compound 6e with excellent inhibitory activity IC50 = 8.8, 12, 2.2 nM, respectively, can effectively induce apoptosis cancer cell lines. kinase profiling showed selectivity specificity. Compound induces G2/M arrest in high...
Despite initial progress in preclinical models, most known histone deacetylase inhibitors (HDACis) used as a single agent have failed to show clinical benefits nearly all types of solid tumours. Hence, the efficacy HDACis tumours remains uncertain. Herein, we developed hybrid HDAC inhibitor that sensitized HDAC-targeted treatment. Methods: A molecule, Roxyl-zhc-84 was designed and synthesized with novel architecture. The pharmacokinetics toxicity were analysed. antitumour effects on...
Background Carotid artery stenosis (CAS) may cause many cerebrovascular diseases, and a biomarker for screening monitoring is needed. This study focused on the clinical significance of long-chain non-coding RNA (lncRNA) activated by DNA damage (NORAD) in patients with CAS aimed to search potential biomarkers CAS. Methods Eighty-six asymptomatic 60 healthy individuals were enrolled, corresponding data serum samples collected. The expression NORAD was detected reverse transcription-quantitive...
Abstract The low cell engraftment after transplantation limits the successful application of stem therapy and exact pathway leading to acute donor death following is still unknown. Here we investigated if processes involved in preparation could initiate downregulation adhesion-related survival signals further affect transplantation. Human embryonic cell-derived endothelial cells (hESC-ECs) were suspended PBS or Matrigel kept at 4 °C. Quantitative RT-PCR analysis was used test adhesion...
// Liang Lin 1, * , Fan Yan 3, Dandan Zhao 4, Meng Lv 2 Xiaodong 5 Hui Dai 1 Xiaodan Qin Zhang Jie Hao Xiuyuan Sun Yanhui Yin Xiaojun Huang Jun Jin Lu Qing Ge Key Laboratory of Medical Immunology, Ministry Health, Department School Basic Sciences, Peking University Health Science Center, Beijing 100191, China Institute Hematology, People's Hospital, 100044, 3 Tianjin Cancer and 300060, 4 Jining No.1 Jining, Shandong 272011, Hangzhou Hang Zhou 310002, These authors have contributed equally to...
ABSTRACT Introduction: Prior studies have shown that about half of critically ill patients in intensive care units (ICUs) abnormal blood glucose. Both hyperglycemia and hypoglycemia increase the risk death patients; therefore, controlling glucose such is crucial. There a significant gap between clinical practice current best evidence regarding glycemic control ICU. Aim: This implementation project aimed to improve for tertiary hospital China by promoting practices. Methods: was conducted...
Janus particles are emerging as structurally unique drug carriers with the potential to deliver multiple drugs and agents. Although synthesis methods have been extensively explored fabricate particles, it remains a challenge generate drug-loaded through an economical, high throughput technique. Here, we report formation of first drug-loaded, micro-scale prepared using single-step emulsion solvent evaporation approach. Our results revealed that both net charge molecules (i.e. glibenclamide,...
A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation transcription, were synthesised. systematic study enzymatic cellular assays led to identification compound X22 with a nanomolar potency against CDK4 CDK9 potent antiproliferative activities panel tumour lines. could induce arrest apoptosis cancer dose-dependently inhibits signalling pathways downstream CDKs cells. In vivo antitumor activity assays, oral...
Human embryonic stem (hES) cells have a potential use for the repair and regeneration of injured tissues. However, teratoma formation can be major obstacle hES-mediated cell therapy. Therefore, tracking fate function transplanted hES with noninvasive imaging could valuable better understanding biology physiology formation. In this study, were stably transduced double fusion reporter gene consisting firefly luciferase enhanced green fluorescent protein. Following bioluminescence histology, we...
// Tiansuo Zhao 1 , He Ren Xiuchao Wang Pengfei Liu 2 Fan Yan 3 Wenna Jiang Yang Li Jing John G. Gribben 4 Jia Jihui Hao Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Institute Hospital, National Clinical Research Center for Cancer, Tianjin, China Department Lymphoma, Immunology Biotherapy, Centre Haemato-Oncology, Barts Institute, Queen Mary London, UK Correspondence to: Hao, e-mail: haojihui@tjmuch.com Jia, L.jia@qmul.ac.uk Keywords: DLBCL, rituximab,...
Garcinia mangostana Linn. (Guttiferae) pericarp is used as a traditional medicine in South Asia to treat inflammatory diseases.This study investigates therapeutic effects of G. ethanol extract (MAN) on collagen-induced arthritis (CIA) and interactions with methotrexate vivo.Male Sprague-Dawley rats CIA were treated MAN (0.5 g/kg/day), mg/kg, bw) or combination both for 36 days, respectively (n = 8/group). Another eight healthy served normal model control, respectively. Therapeutic evaluated...