A5072771186- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Tryptophan and brain disorders
- Calcium Carbonate Crystallization and Inhibition
- Immune Response and Inflammation
- Bone Tissue Engineering Materials
- Cancer, Hypoxia, and Metabolism
- Luminescence Properties of Advanced Materials
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Neuroscience and Neuropharmacology Research
- Advanced Photocatalysis Techniques
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Advanced ceramic materials synthesis
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- ZnO doping and properties
- Circular RNAs in diseases
- Microtubule and mitosis dynamics
- Lung Cancer Treatments and Mutations
Affiliated Hospital of Guizhou Medical University
2016-2025
Guiyang Medical University
2016-2025
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Nankai University
2017-2022
Southwest Jiaotong University
2022
Louisiana State University Health Sciences Center New Orleans
2022
Hefei Institutes of Physical Science
2022
Chinese Academy of Sciences
2022
Wuhan Institute of Technology
2007-2021
BACKGROUND Primary hepatocellular carcinoma (HCC) is a malignant tumor that common China. Early diagnosis of great significance for improving treatment efficiency. GPC3 level closely related to HCC occurrence. This study investigated expression in patient serum and tissue, assessed the combined AFP detection diagnosis. MATERIAL AND METHODS A total 76 patients our hospital were enrolled. Immunohistochemistry was applied test cancer tissue para-carcinoma tissue. ELISA RT-PCR used detect serum....
BACKGROUND Hepatocellular carcinoma (HCC) is the most important cause of cancer-related deaths worldwide. Pirfenidone an orally available small molecule with therapeutic potential for fibrotic diseases. MATERIAL AND METHODS In this study, we analyzed effects different pirfenidone concentrations on proliferation HepG2 HCC cells using Cell Counting Kit-8 (CCK-8) and colony formation assays. Flow cytometry was performed to measure apoptotic cells. Western blot analysis detect expression...
BACKGROUND Shikonin is a component of Chinese herbal medicine. The aim this study was to investigate the effects shikonin on cell migration papillary thyroid cancer cells TPC-1 line in vitro and expression levels phosphate tensin homolog deleted chromosome 10 (PTEN) DNA methyltransferase 1 (DNMT1) genes. MATERIAL AND METHODS Cell Counting Kit-8 (CCK-8) assay performed evaluate proliferation cells, normal HTori-3, vitro. A transwell motility used analyze cells. Western blot determine PTEN...
Background/Objective: Topoisomerases type IIA (TOP2A) was identified to present with a high-expression pattern in cervical cancer. However, TOP2A role the progression of cancer remains unknown. Here, we aimed explore effect and reveal underlying mechanism migration, invasion epithelial–mesenchymal transition (EMT) Materials Methods: The expression profiles 20 paired tissues paracancerous normal were detected by using Western blotting assay. Transwell chambers used test cell migration...
Background：Aloe-emodin, an anthraquinone present in aloe latex, has been shown to have anti-proliferative properties cervical cancer disease, all cases of which are almost caused by human papillomavirus (HPV), with the products E6/E7. It is suggested that aloe-emodin may play important role HPV-induced cells. Methods：Hela and SiHa cells were treated various concentrations aloe-emodin. MTT assay flow cytometry used identify cell growth apoptosis. The expressions HPV E6, E7 GLUT1 (glucose...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high morbidity and mortality worldwide. Angiogenesis essential for HCC progression metastasis. Some angiogenesis-related genes promote this process, whereas other antiangiogenic inhibit growth Therefore, finding new potential biomarkers prognosis prediction treatment essential. Public RNAseq clinical data from TCGA GEO database, download GeneCards, MSigDB through single factor analysis Cox, LASSO build risk...
ABSTRACT Recombinase activation gene 1 (RAG-1) function is essential for V(D)J recombination in T-cell-receptor and immunoglobulin rearrangements whereby the immune system may encode memories of a vast array antigens. The RAG-1 also localized to neurons hippocampal formation related limbic regions that are involved spatial learning memory as well other parameters neurobehavioral performance. Since unique ability shared by brain, we tested hypothesis loss brain would influence performance...
A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation transcription, were synthesised. systematic study enzymatic cellular assays led to identification compound X22 with a nanomolar potency against CDK4 CDK9 potent antiproliferative activities panel tumour lines. could induce arrest apoptosis cancer dose-dependently inhibits signalling pathways downstream CDKs cells. In vivo antitumor activity assays, oral...
Low-grade gliomas (LGG) account for 20-25% of all gliomas. In this study, we assessed whether metabolic status was correlated with clinical outcomes in LGG patients using data from The Cancer Genome Atlas (TCGA).
Abstract Na + was incorporated into red‐emitting CaMoO 4 :Eu 3+ phosphor to form solid solutions and reduce the crystal symmetry. For a fixed Eu concentration, luminescent properties as function of concentrations were systematically studied under near‐ultraviolet (UV) excitation. Enhanced red emission at 613 nm observed strongest intensity 4.5 times that sample without . Differing from charge‐compensation mechanism, this enhancement related structural distortion decreasing centrosymmetry....
Accumulated evidence has demonstrated that aerobic glycolysis serves as a regulator of tumor cell growth, invasion, and angiogenesis. Herein, we explored the role protein disulfide isomerase family 6 (PDIA6) in progression oral squamous carcinoma (OSCC).The expression pattern PDIA6 OSCC tissues was determined by qPCR western blotting. Lentivirus small interfering RNAs (siRNAs) were introduced into cells to upregulate downregulate expression. CCK-8, flow cytometry, transwell,...
On the basis of novel pyrazino[2,3-c]quinolin-2(1H)-one scaffold, we designed and identified a highly selective, potent oral mTOR inhibitor, 9m. Compound 9m showed low nanomolar activity against (IC50 = 7 nM) greater selectivity over related PIKK family kinases, which demonstrated only modest 3 out 409 protein kinases. In vitro assays, compound exhibited high potency human breast cervical cancer cells induced tumor cell cycle arrest autophagy. inhibited cellular phosphorylation mTORC1 (pS6...