A5006232455- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- MicroRNA in disease regulation
- melanin and skin pigmentation
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Biochemical Analysis and Sensing Techniques
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- Ovarian function and disorders
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
- Ferroptosis and cancer prognosis
- Diabetes Management and Research
- Gynecological conditions and treatments
- Galectins and Cancer Biology
- Endometriosis Research and Treatment
- Genetic diversity and population structure
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2019-2025
Obstetrics and Gynecology Hospital of Fudan University
2016-2025
State Key Laboratory of Oncogene and Related Genes
2023
Union Hospital
2022
Huazhong University of Science and Technology
2018-2022
Wuhan Third Hospital
2019-2022
Shandong Academy of Sciences
2022
Qilu University of Technology
2022
Fuyang Second People's Hospital
2021
Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via lysosomal pathway. During autophagic process, cells form double-membraned vesicles called autophagosomes that sequester disposable materials in cytoplasm finally fuse with lysosomes. In present study, we investigated inhibition autophagy by synthesized compound, MHY1485, culture system using Ac2F rat hepatocytes. Autophagic flux was measured to evaluate activity....
Abstract Background Intercellular communication is crucial for breast cancer progression and metastasis. However, the role of cancer-derived exosomes their microRNA (miRNA) cargoes mediating intercellular requires further investigation. Methods Cancer-derived were isolated using differential centrifugation differentially expressed miRNAs determined by microarrays qRT-PCR analysis. Cell proliferation, wound-healing, Transwell invasion, tumor xenograft assays used functional research. Plasma...
Abstract Background The mechanism underlying cervical carcinogenesis that is mediated by persistent human papillomavirus (HPV) infection remains elusive. Aims Here, for the first time, we deciphered both temporal transition and spatial distribution of cellular subsets during disease progression from normal cervix tissues to precursor lesions cancer. Materials & Methods We generated scRNA‐seq profiles transcriptomics data nine patient samples, including two HPV‐negative normal,...
To investigate the status of mismatch repair (MMR) and microsatellite instability (MSI) in triple-negative breast cancer (TNBC) to examine correlations between MMR/MSI clinicopathological parameters.We retrospectively collected tissue samples from 440 patients with TNBC constructed microarrays. Protein expression MLH1, MSH2, MSH6, PMS2 was detected by immunohistochemistry (IHC). We also analyzed 195 patient using MSI polymerase chain reaction (PCR) testing. Correlations parameters prognosis...
This study aimed to evaluate the expression status and prognostic role of various immunoregulatory cells test in triple-negative breast cancer (TNBC).The five markers (CD3/CD4/CD8/CD19/CD163) tumor immune was evaluated retrospectively sections from 68 consecutive cases TNBC by immunohistochemistry. Computational image analysis used quantify density distribution each marker within region, invasive margin, hotspots. Immunoscores were calculated using an automated approach. Other clinical...
Background Vascular calcification and increased cardiovascular morbidity mortality are closely related in patients with end‐stage renal disease diabetes mellitus. Specific protein 1 (Sp1) is a transactivation molecule that plays crucial role the regulation of apoptosis, fibrosis, angiogenesis, other pathological disorders. There evidence specific directly stimulates transcription bone morphogenetic 2 ( BMP 2) key process 2–expressing F9 cell model system. Here, we investigated whether Sp1 an...
Abstract Background Previous studies have shown that branched-chain amino acid transferase 1 (BCAT1) is associated with tumour progression in triple-negative breast cancer (TNBC). Furthermore, CD133 has emerged as a novel stem cell marker for indicating progression. However, the prognostic significance of these two markers remains to be verified. This study was conducted investigate correlation between BCAT1 and expression clinicopathological features, well prognosis patients TNBC. Methods...
Calreticulin (CALR) preserves reticular homeostasis by maintaining correct protein folding within the endoplasmic reticulum. Immunogenic cell death (ICD) is a regulated form of and could activate adaptive immune response. As one damage-associated molecular patterns during ICD process, surface-exposed CALR resulted in activation Here, we evaluated expression cohort 231 untreated triple-negative breast cancer (TNBC) determined correlations between clinicopathologic parameters, programmed...
Abstract Approximately 20% of HER2 positive breast cancer develops disease recurrence after adjuvant trastuzumab treatment. This study aimed to develop a molecular prognostic model that can reliably stratify patients by risk developing recurrence. Using miRNA microarrays, nine miRNAs differentially expressed between the recurrent and non-recurrent were identified. Then, we validated expression these using qRT-PCR in training set (n = 101), generated 2-miRNA (miR-4734 miR-150-5p) based...
<b><i>Introduction:</i></b> The adverse effect of fractures by different aromatase inhibitor (AI) drugs has not been thoroughly assessed in real-world studies. <b><i>Objective:</i></b> To assess the events breast cancer patients caused AI therapy through Food and Drug Administration Adverse Event Reporting System (FAERS) database. <b><i>Methods:</i></b> FAERS data from January 2004 to December 2018 were sorted out...
Introduction: The role and underlying mechanisms of miR-27b-3p in triple-negative breast cancer (TNBC) remains unclear. Methods: expression level was evaluated 99 TNBC patients with a median follow-up time 133 months. biological functions by targeting PPARG were assessed luciferase reporter assay, CCK-8 Transwell wound healing western blot analysis xenograft models. Results: High found to confer poor prognosis patients. MiR-27b-3p overexpression increased cell proliferation, migration,...
Postmenopausal women are faced with difficulties in colposcopy, such as easy bleeding from epithelial atrophy, and thinning, atypical colposcopy images, unsatisfactory exposure, decreased sensitivity of colposcopy. We aimed to improve the satisfaction postmenopausal evaluate clinical efficacy compound sea-buckthorn oil suppository on topical vaginal pretreatment prior patients who underwent Obstetrics Gynecology Hospital Fudan University April 2023 July 2024 were randomly assigned three...
Paraneoplastic dermatomyositis (DM) is a rare autoimmune condition that primarily affects the skin and muscles; it associated with various malignancies, including breast cancer. The present case report investigates clinical presentation, therapeutic considerations relevant literature regarding DM in context of locally advanced triple-negative cancer (TNBC). A 43-year-old female patient presented progressive myalgia, dysphagia characteristic rashes. Subsequent investigations confirmed TNBC...
There is currently no large sample data of cytology, high-risk human papillomavirus (hrHPV), and colposcopy results vaginal intraepithelial neoplasia (VaIN) in women who underwent hysterectomy those did not. We aim to explore the values hrHPV, reports detecting VaIN. A retrospective study diagnosed with VaIN by colposcopy-directed biopsy was performed at Obstetrics Gynecology Hospital Fudan University, China, between January 1, 2014, December 31, 2014. total 529 cases were diagnosed,...