A5067637611- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Full-Duplex Wireless Communications
- Polyomavirus and related diseases
- Pancreatic function and diabetes
- Ferroptosis and cancer prognosis
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Pancreatic and Hepatic Oncology Research
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Antenna Design and Analysis
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Molecular Biology Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Phytochemical Studies and Bioactivities
- Connexins and lens biology
- Parkinson's Disease Mechanisms and Treatments
- Nephrotoxicity and Medicinal Plants
The People's Hospital of Guangxi Zhuang Autonomous Region
2025
University of International Business and Economics
2025
Guangxi Medicinal Botanical Garden
2025
University of California, San Diego
2017-2024
Weatherford College
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Zhongnan Hospital of Wuhan University
2021-2023
Wuhan University
2021-2023
University of Montana
2020-2023
Shanghai Jiao Tong University
2021
Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of tumor. Metastasis reflects most adverse outcome prostate cancer, and to date there are no reliable or serum biomarkers can reliably predict which patients at higher risk developing metastatic disease. Understanding differences biology organ confined primary tumors essential for new prognostic markers therapeutic targets.Using Affymetrix oligonucleotide arrays,...
Abstract Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible generating most of the energy needed to sustain contraction. Dysfunctional mitochondria normally degraded via intracellular degradation pathways that converge on lysosome. Here, we identified an alternative mechanism eliminate when lysosomal function compromised. We show inhibition leads increased secretion in large extracellular vesicles (EVs). The EVs produced multivesicular...
The microenvironment of pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma (desmoplasia) generated cancer-associated fibroblasts (CAFs) derived from stellate cells (PSCs) and (PFs). Using an unbiased GPCRomic array approach, we identified 82 G-protein-coupled receptors (GPCRs) commonly expressed CAFs 5 primary PDAC tumors. Compared with PSCs PFs, have increased expression GPR68 (a proton-sensing GPCR), the results confirmed immunoblotting, Cancer Genome Atlas...
The degradation of macromolecules and organelles by the process autophagy is critical for cellular homeostasis often compromised during aging disease. Beclin1 Beclin2 are implicated in induction, these homologs share a high degree amino acid sequence similarity but have divergent N-terminal regions. Here, we investigated functions Beclin regulating mitophagy, specialized form that targets mitochondria. Both contributed to autophagosome formation, mechanism formation independent either...
Purpose Cystatin 2 (CST2) is a cysteine protease inhibitor, and recent research suggests its potential involvement in cancer development. However, role the occurrence, progression, prognosis of pan-cancer has not been systematically investigated. Materials methods This study comprehensively analyzes differential expression CST2 pan-cancer. The distribution patterns were examined using single-cell datasets. Furthermore, we conducted comprehensive evaluation correlation between various...
Abstract Advancing age is a major risk factor for developing heart disease, and the biological processes contributing to aging are currently under intense investigation. Autophagy an important cellular quality control mechanism that reduced in tissues with but molecular mechanisms underlying age‐associated defects autophagy remain poorly characterized. Here, we have investigated how autophagic process altered aged mouse hearts. We report activity hearts due reduction autophagosome formation....
Aims Numerous studies have suggested that transfusion of red blood cells (RBCs) stored over a long period time may induce harmful effects due to storage-induced lesions. However, the underlying mechanisms responsible for this damage not been identified. Furthermore, it is unclear why and how up 30% long-stored RBCs disappear from circulation within 24 hours after transfusion. The aim study was determine cell number different ages changes during storage these undergo cumulative structural...
// Fu Wang 1 , Hui Ma Wen-Jing Liang Jing-Jing Yang Xue-Qing Mei-Rong Shan Yuan Chen Min Jia 2 Ya-Ling Yin 3 Xue-Ying Sun 4 Jia-Ning Zhang 5 Qi-Sheng Peng 6 Yu-Guo Li-Ying Liu Li Tao Guo and Shuang-Xi The Key Laboratory of Cardiovascular Remodeling Function Research, Qilu Hospital, Shandong University School Medicine, Jinan, China Department Rehabilitation Jinan Municipal Hospital Traditional Chinese Pharmacology, College Pharmacy, Xinxiang Medical University, Xinxiang, Pharmaceutical...
Aspirin has been used for the secondary prevention and treatment of cardiovascular disease several decades. We investigated roles transcriptional factor activator protein 2α (AP-2α) in beneficial effects aspirin growth vulnerability atherosclerotic plaque.In mice deficient apolipoprotein E (Apoe-/-), (20, 50 mg/kg/day) suppressed progression atherosclerosis aortic roots increased plaque stability carotid plaques induced by collar-placement. In vivo lentivirus-mediated RNA interference AP-2α...
// Hui Ma 1, 2 , Jing Kong 3 Yu-Lin Wang Jun-Long Li Nai-Hao Hei Xin-Ran Cao Jing-Jing Yang Wen-Jiang Yan Wen-Jing Liang Hong-Yan Dai 4 Bo Dong 1 Department of Pediatrics, Shandong Provincial Hospital Affiliated to University, Jinan, China Cardiology, Key Laboratory Cardiovascular Remodeling and Function Research, Qilu Hospital, department, Qingdao Municipal Qingdao, Correspondence to: Dong, email: dongbo1@medmail.com.cn Keywords: angiotensin-converting enzyme 2, cilazapril,...
Uncaria rhynchophylla is listed in the Chinese pharmacopoeia as one of five botanical sources traditional medicine Gou-Teng, which has been utilized for treatment mental and cardiovascular disorders. This particular species well-known China its hook-like structures originating from leaf axils. Despite available reports on chloroplast genome, there persists a notable lack understanding concerning structural variations evolution mitochondrial genome. knowledge gap hinders our ability to fully...
Background: Smilax glabra (S. glabra) and zeylanica zeylanica), two medicinally important species within the genus Smilax, have been widely used in Traditional Chinese Medicine (TCM) for treatment of rheumatism, traumatic injuries, related ailments. Despite their medicinal significance, research on mitochondrial DNA (mtDNA) remains limited. Methods: We utilized NovaSeq 6000 PromethION sequencing platforms to assemble complete genomes zeylanica, conducted in-depth comparative genomic...
To investigate the impact of human papillomavirus (HPV) status on head and neck squamous cell carcinoma (HNSCC) arising from different anatomic subsites.HNSCC patients with known HPV Surveillance, Epidemiology, End Results (SEER) database between 2010-2015 were included in our analysis. Patients classified into three categories HNSCC according to Site recode ICD-O-3/WHO 2008 Primary Site-labeled, namely, oropharynx, hypopharynx, nasopharynx. Logistic regression model was conducted evaluate...
Background/Aims: Fibroblast growth factor 2 (FGF2) plays a predominant role during angiogenesis in the adventitia and atherosclerotic plaque. A dilemma exists, however, as to whether angiogenic stimulation by FGF2 for prevention treatment of atherogenesis is feasible. The aim this study investigate effect 18-kDa FGF-2 isoform on atherosclerosis progression high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice. Methods: We established model using ApoE gene double They were randomly...
Myeloid cell leukemia-1 (Mcl-1) is a unique antiapoptotic Bcl-2 member that critical for mitochondrial homeostasis. Recent studies have demonstrated Mcl-1's functions extend beyond its traditional role in preventing apoptotic death. Specifically, data suggest Mcl-1 plays regulatory autophagy, an essential degradation pathway involved recycling and eliminating dysfunctional organelles. Here, we investigated whether regulates autophagy the heart. We found cardiac-specific overexpression of had...