A5100427488- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- Glioma Diagnosis and Treatment
- Mesenchymal stem cell research
- Bone Tumor Diagnosis and Treatments
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Connective Tissue Growth Factor Research
- Cell Adhesion Molecules Research
- Renin-Angiotensin System Studies
- Pulsars and Gravitational Waves Research
- Colorectal Cancer Treatments and Studies
- Nanomaterials for catalytic reactions
First Hospital of Jilin University
2021-2025
Henan University of Technology
2025
Cleveland Clinic Lerner College of Medicine
2010-2025
China Medical University
1998-2025
Technical Institute of Physics and Chemistry
2025
University of Chinese Academy of Sciences
2025
Jilin University
2021-2025
Sun Yat-sen University
2021-2025
Xinxiang Medical University
2025
Harbin University of Commerce
2024
Significance An important part of the response to invading pathogens is activation transcription factor STAT3 in IL-6. This normal terminated rapidly by major negative regulator suppressor cytokine signaling 3 (SOCS3). Abnormal prolonged contributes pathology cancer and chronic inflammatory diseases. We show that results from association IL-6 receptor with epidermal growth receptor, which turn activates a way not inhibited SOCS3. Prolonged supports sustained expression subset proteins play...
Significance We describe unexpected cooperation between two cytokines that are important in regulating the growth of cancers, namely, type I interferons (IFNs) and interleukin 6 (IL6). It is well established IL6 vital for ability many tumor types to prosper, work current paper reveals signaling pathway driven by IFN, which also evident increases expression through a direct effect on gene. The findings may help identify new antitumor targets therapy.
Autoimmune hepatitis (AIH) is increasingly affecting human health but pharmacotherapies remain to be identified. Growing evidence reveals that ferroptosis, a newly recognized form of programmed cell death, critical for AIH. However, the exact mechanisms ferroptotic cascade elusive. Data in this study showed ferroptosis aggravation was associated with protectively-elevated fibroblast growth factor 4 (FGF4) expression Concanavalin A (ConA)-induced AIH liver injury, these effects being...
Epidermal growth factor receptor (EGFR) is a clinical therapeutic target to treat subset of non-small cell lung cancer (NSCLC) harboring EGFR mutants. However, some patients with similar kind mutation show intrinsic resistance tyrosine kinase inhibitors (TKI). It indicates that other key molecules are involved in the survival these cells. We showed here 2-[(aminocarbonyl)amino]-5 -(4-fluorophenyl)-3- thiophenecarboxamide (TPCA-1), previously reported inhibitor IκB kinases (IKK), blocked...
Epigenetic modifications are important mechanisms responsible for cancer progression. Accumulating data suggest that (−)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of green tea, may hamper carcinogenesis by targeting epigenetic alterations. We found signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing 2 (SCUBE2), a tumor suppressor gene, was hypermethylated in breast tumors. However, it is unknown whether EGCG...
Signal abnormalities in human cells usually cause unexpected consequences for individual health. We focus on these kinds of events involved JAK-STAT signal pathways, especially the ones triggered by aberrant activated STAT3, an oncoprotein which participates essential processes cell survival, growth and proliferation many types tumors, as well immune diseases. By establishing a STAT3 based high-throughput drug screening system lung cancer A549 cells, we have screened library from natural...
Type I interferons (IFN-I) protect us from viral infections. Signal transducer and activator of transcription 2 (STAT2) is a key component interferon-stimulated gene factor 3 (ISGF3), which drives expression in response to IFN-I. Using electron microscopy, we found that, naive cells, U-STAT2, lacking the activating tyrosine phosphorylation, forms heterodimer with U-STAT1 an inactive, anti-parallel conformation. A novel phosphorylation STAT2 on T404 promotes IFN-I signaling by disrupting...
To investigate the status of mismatch repair (MMR) and microsatellite instability (MSI) in triple-negative breast cancer (TNBC) to examine correlations between MMR/MSI clinicopathological parameters.We retrospectively collected tissue samples from 440 patients with TNBC constructed microarrays. Protein expression MLH1, MSH2, MSH6, PMS2 was detected by immunohistochemistry (IHC). We also analyzed 195 patient using MSI polymerase chain reaction (PCR) testing. Correlations parameters prognosis...
Although the Chufeng Qingpi Decoction (CQD) has demonstrated clinical effectiveness in treatment of schistosomiasis, precise active components and underlying mechanisms its therapeutic action remain elusive. To achieve a profound comprehension, we incorporate network pharmacology, bioinformatics analysis, molecular docking, dynamics simulations as investigative methodologies within our research framework.
Abstract Background GC is a highly heterogeneous tumor with different responses to immunotherapy, and the positive response depends on unique interaction between microenvironment (TME). However, currently available methods for prognostic prediction are not satisfactory. Therefore, this study aims construct novel model that integrates relevant gene sets predict clinical efficacy of immunotherapy prognosis patients based machine learning. Methods Seven datasets were collected from Gene...
Skin disease is one of the most common types human diseases, which may happen to everyone regardless age, gender or race. Due high visual diversity, diagnosis highly relies on personal experience; and there a serious shortage experienced dermatologists in many countries. To alleviate this problem, computer-aided with state-of-the-art (SOTA) machine learning techniques would be promising solution. In paper, we aim at understanding performance convolutional neural network (CNN) based...
The heterogeneity of cancer-associated fibroblasts (CAFs) in head and neck squamous cell carcinoma (HNSCC) has been widely acknowledged, but not yet elucidated. potential roles clinical relevance CAFs subclusters HNSCC progression remain obscure.In this study, we combined single-cell bulk tissue transcriptome profiles with data from Cancer Genome Atlas (TCGA). Seurat package was used to perform RNA-seq analysis distinguish distinct subtypes. Prognostic several markers assessed functional...
In cancer cells, endogenous or therapy-induced DNA damage leads to the abnormal presence of in cytoplasm, which triggers activation cGAS (cyclic GMP–AMP synthase) and STING (stimulator interferon genes). STAT2 suppresses cGAMP-induced expression IRF3-dependent genes by binding STING, blocking its intracellular trafficking, is essential for full response activation. reshapes signaling inhibiting induction IRF3-dependent, but not NF-κB–dependent genes. This noncanonical activity regulated...