A5027686431- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Skin Protection and Aging
- Wound Healing and Treatments
- Reconstructive Facial Surgery Techniques
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Dermatologic Treatments and Research
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- FOXO transcription factor regulation
- Cancer Immunotherapy and Biomarkers
- Magnesium Alloys: Properties and Applications
- Nerve Injury and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Telomeres, Telomerase, and Senescence
- Orthopaedic implants and arthroplasty
- Facial Rejuvenation and Surgery Techniques
Northeast Normal University
2024-2025
China Medical University
2015-2025
First Hospital of China Medical University
2015-2025
First Affiliated Hospital of Hebei Medical University
2025
Hebei Medical University
2025
Qilu Hospital of Shandong University
2024-2025
Worcester Polytechnic Institute
2021-2024
Lanzhou University
2023
First Hospital of Lanzhou University
2023
Shanxi Provincial Cancer Hospital
2016-2022
Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability, and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated researches composition design, preparation processing, surface modification, degradation modes Mg alloys. Nevertheless, mechanisms by which promote bone healing remain elusive. This review gives an account specific promoting from four...
The field of bone regeneration has always been a hot and difficult research area, there is no perfect strategy at present. As new type biodegradable material, magnesium alloys have excellent mechanical properties promoting ability. Compared with other inert metals, significant advantages broad application prospects in the regeneration. By searching official Web sites databases various funds, this paper summarizes status composites introduces latest scientific achievements clinical...
We compared the health-related quality-of-life of patients with newly diagnosed multiple myeloma aged over 65 years or transplant-ineligible in pivotal, phase III FIRST trial. Patients received: i) continuous lenalidomide and low-dose dexamethasone until disease progression; ii) fixed cycles for 18 months; iii) melphalan, prednisone, thalidomide months. Data were collected using validated questionnaires (QLQ-MY20, QLQ-C30, EQ-5D). The analysis focused on EQ-5D utility value six domains...
Tissues undergo a process of degeneration as the body ages. Mesenchymal stem cells (MSCs) have been found to major potential in delaying aging tissues and organs. However, mechanism underlying anti-aging effects MSC is not clear which limits clinical applications. In this study, we used adipose-derived mesenchymal (ADSCs) perform treatments on senescent progeroid animal models. Following intervention with ADSCs, replicative senescence was delayed metabolic homeostasis transformed from...
It is of profound significance for clinical bone regeneration to clarify the specific molecular mechanism from which we found that osteogenic differentiation adipose-derived stem cells (ADSCs) will be probably promoted by exosomes.By means lentiviral transfection, miR-130a-3p overexpression and knockdown ADSCs were constructed. Alizarin Red S was used detect calcium deposits, qPCR osteogenesis-related genes, verify effect on ADSCs. CCK-8 proliferation The target binding between SIRT7...
Human adipose-derived stem cells (ADSCs) can release exosomes; however, their specific functions remain elusive. In this study, we verified that exosomes derived from osteogenically differentiated ADSCs promote osteogenic differentiation of ADSCs. Furthermore, in order to investigate the importance exosomal microRNAs (miRNAs) ADSCs, used microarray assays analyze expression profiles miRNAs undifferentiated as well ADSCs; 201 were upregulated and 33 downregulated between two types exosomes....
Adipose-derived stem cells (ADSCs) are a type of multipotent mesenchymal with immunosuppressive capacities. However, the underlying mechanisms involved in inhibitory effects ADSCs on T not completely elucidated. In this study, human peripheral blood mononuclear (PBMCs) stimulated anti-CD3/CD28 antibody-coated beads were cultured or without allogeneic (ADSC-to-PBMC ratio, 1:5). Surface marker levels, violet-labeled cell proliferation, apoptosis, interferon-gamma (IFN-gamma) production, and...
Abstract Background Human adipose-derived stem cells (hADSCs) are with the potential to differentiate in multiple directions. miR-204-5p is expressed at low levels during osteogenic differentiation of hADSCs, and its specific regulatory mechanism remains unclear. Here, we aimed explore function possible molecular hADSCs. Methods The expression patterns miR-204-5p, Runx2 , alkaline phosphatase ( ALP ), osteocalcin OCN forkhead box C1 FOXC1 ) growth factor 7 GDF7 hADSCs osteogenesis were...
Neutrophilic inflammation contributes to multiple chronic inflammatory airway diseases, including asthma and rhinosinusitis with nasal polyps (CRSwNP), is associated an unfavorable prognosis. Here, using single-cell RNA sequencing (scRNA-seq) profile human mucosa obtained from the inferior turbinates, middle of CRSwNP patients, we identify two IL-1 signaling-induced cell subsets—LY6D+ club cells IDO1+ fibroblasts—that promote neutrophil recruitment by respectively releasing S100A8/A9...
Abstract Exosomes exhibit great therapeutic potential in bone tissue engineering. The study aimed to investigate whether the exosomes derived from human adipose-derived stem cells (hADSCs-Exos) during different time-span of osteogenic differentiation could promote osteogenesis. appropriate concentrations hADSCs-Exos enhance proliferation, migration and osteogenesis were also examined. PKH67 labelled was used detect internalization ability hADSCs. abilities hADSCs after treatment with...