A5102912445- Spine and Intervertebral Disc Pathology
- Plant Stress Responses and Tolerance
- Advanced machining processes and optimization
- Advanced Surface Polishing Techniques
- Animal Nutrition and Physiology
- Gut microbiota and health
- Plant Toxicity and Pharmacological Properties
- Osteoarthritis Treatment and Mechanisms
- Advanced Machining and Optimization Techniques
- Augmented Reality Applications
- Probiotics and Fermented Foods
- Photosynthetic Processes and Mechanisms
- Engineering and Test Systems
- Spatial Cognition and Navigation
- Water Treatment and Disinfection
- Water Systems and Optimization
- Toxic Organic Pollutants Impact
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Art, Technology, and Culture
- Advanced Antenna and Metasurface Technologies
- Nanoparticle-Based Drug Delivery
- Ferroelectric and Negative Capacitance Devices
- Berberine and alkaloids research
- Air Quality Monitoring and Forecasting
Shenyang Agricultural University
2022-2025
Shanghai Ninth People's Hospital
2021-2023
Shanghai Jiao Tong University
2010-2023
Ministry of Agriculture and Rural Affairs
2023
Chinese Academy of Agricultural Sciences
2023
Tianjin Children's Hospital
2018-2022
Northwest A&F University
2021-2022
Affiliated Hospital of Jining Medical University
2020
China Pharmaceutical University
2017-2019
State Key Laboratory of Natural Medicine
2019
Quercetin, a well-known flavonoid, has been demonstrated to exert beneficial effects on intestinal functions and gut microbiota in birds. In this study, we investigated the of quercetin supplementation inflammatory responses, barrier microbial community LPS-challenged laying hens. A total two hundred eighty-eight 32-wk-old Jingfen No.6 hens were randomly assigned 3 groups, CON group, LC group LQ group. was fed with 0.4 mg/kg at end 12 wk, groups challenged intraperitoneally...
Salt stress is a major abiotic that interferes with plant growth and affects crop production. Dehydrin (DHN), member of the late embryogenesis abundant (LEA) protein family, was considered to be involved in protective reaction dehydration. Our previous research has shown overexpression Suaeda salsa SsDHN gene enhances tolerance salt tobacco. However, on its protection photosynthesis under remains unclear. In this study, (SsDHN-OE) tobacco plants were utilized study effect stress. findings...
The present study aimed to explore the function of NEAT1 on non-small cell lung cancer (NSCLC), as well its underlying mechanisms.Quantitative realtime PCR (qRT-PCR) was used measure expression in NSCLC tissues and cells. MTT assay transwell were performed detect proliferation, migration invasion. Potential target genes identified via luciferase reporter assay. Protein analysis through western blotting.The expressions significantly higher both cells than normal controls. High associated with...
The aim of this study was to investigate the effects different probiotic fermented diets on production performance and intestinal health laying hens. A total 360 healthy 22-wk-age Jingfen No. 6 layers were randomly divided into 4 treatments: basal diet (CON); supplemented with 6% Clostridium butyricum feed (CB); Lactobacillus crispatus (LC); salivarius (LS). experiment lasted for 8 wk. results showed that levels crude fiber, β-glucan pH decreased significantly after fermentation (P < 0.05)....
BACKGROUND:Osteoarthritis (OA) is the most common joint disease and characterized by progressive degeneration of articular cartilage. The molecular basis OA involves various factors has not been fully clarified. Autophagy a conserved catabolic process that cellular degradation through lysosomal machinery. MATERIAL AND METHODS:We found miRNA-411 regulates chondrocyte autophagy in targeting hypoxia-inducible factor 1 alpha (HIF-1α) identified related mechanism. condition C28/I2 cells was...
Enhancer of zeste homolog 2 (EZH2) is a novel oncogene that can specifically trimethylate the histone H3 lysine 27 (H3K27me3) to transcriptionally inhibit expression downstream tumor-suppressing genes. As small molecular inhibitor EZH2, 3-Deazaneplanocin (DZNep) has been widely studied due role tumor suppression. With roles epigenetic regulation bone cells emerged in past decades, property and mechanism DZNep on enhancing osteogenesis had reported attracted great deal attention recently....
Osteoarthritis (OA), a chronic degenerative disease, is major cause of pain, disability, and reduced quality life among the elderly worldwide. The key to treating it early prevention effective intervention. anti-inflammatory effects scutellarin (SCU), flavonoid derived from Erigeron breviscapus, have been increasingly reported. However, mechanism by which SCU affects OA remains unclear. This study aimed investigate therapeutic potential molecular mechanisms in development OA. Here, we found...
Intervertebral disc degeneration (IDD) is the main cause of low back pain. An increasing number studies have suggested that inflammatory response or senescence nucleus pulposus (NP) cells strongly associated with progress IDD. Eupatilin, flavonoid extracted from Artemisia , was reported to be inhibition intracellular and cells. However, relationship between eupatilin IDD still unknown. In this study, we explored role in tumor necrosis factor-α (TNF-α)-induced activation signaling pathways NP...
This experiment was conducted to investigate the effects of different compound probiotics on performance, cecal microflora, and intestinal immunity laying hens. A total 270 Jing Fen No.6 (22-week-old) were randomly divided into 3 groups: basal diet (CON); supplemented with 6% fermented feed by Bacillussubtilis,Lactobacillus, Yeast (FA); B C. butyricum L. salivarius (FB). Phytic acid, trypsin inhibitor, β-glucan concentrations, pH value in lower than CON group (p < 0.05). The conversion ratio...
Multidrug resistance (MDR) of hepatocellular carcinoma is a serious problem. Although CD13 biomarker in human liver cancer stem cells, the relationship between and MDR remains uncertain. This study uses cell model to understand role enhancing cytotoxic effect chemotherapy agents. Cytotoxic agents can induce expression. inhibitor, bestatin, enhances antitumor Meanwhile, CD13-targeting siRNA neutralizing antibody enhance 5-fluorouracil (5FU). overexpression increases survival upon treatment,...
Intervertebral disc (IVD) degeneration (IVDD) is a characteristic of the dominating pathological processes nucleus pulposus (NP) cell senescence, abnormal synthesis and irregular distribution extracellular matrix (ECM), tumor necrosis factor-α (TNF-α) induced inflammation. Nowadays, IVD acid environment variation which accelerates mentioned above arouses researchers' attention. KAN0438757 (KAN) an effective inhibitor selective metabolic kinase...
Objective Biliary atresia (BA) presents as a severe infantile cholangiopathy disease, characterized by progressive liver fibrosis and the resulting poor prognosis. Leukocyte cell-derived chemotaxin 2 (LECT2) was proposed key gene associated with hepatic in BA, but molecular mechanism is unclear. This study aims to investigate function of LECT2 BA. Methods A total 53 patients were enrolled this study; 36 17 control cholestasis, including congenital biliary dilations, hypoplasia, inspissated...
Abstract Hypertrophic ligamentum flavum (LF) is a main factor responsible for lumbar spinal stenosis (LSS); however, the exact mechanisms of pathogenesis these processes remain unknown. This study aimed to elucidate whether circular RNAs and microRNAs regulate LF LSS, especially focusing on circPDK1 (hsa_circ_0057105), circRNA targeting pyruvate dehydrogenase kinase 1 differentially expressed in tissues between disk herniation LSS patients. The circPDK1/miR‐4731 miR‐4731/TNXB (Tenascin XB)...
Flow fields, geodesics, and deformed volumes are natural sources of families space curves that can be characterized by intrinsic geometric properties such as curvature, torsion, Frenet frames. By expressing a curve's moving coordinate frame an equivalent unit quaternion, we reduce the number components must displayed from nine with six constraints to four one constraint. We then assign color each curve point dotting its quaternion 4D light vector, or plot values separately in three-sphere....
The study investigated the effects of supplementation bile acids in drinking water on antitrichomonal activity, growth performance, immunity and microbial composition pigeon. A total 180 pairs White King parent pigeons were randomly assigned to 5 treatments 6 replications with 12 squabs each replicate. control (CON) group drank without any additions. metronidazole (MTZ) 500 μg/mL for 7 d additions other days. else groups 500, 750, 1,250 acid (BAL, BAM, BAH) 28 d. results showed that...
We propose an interactive method for exploring topological spaces based on the natural local geometry of space. Examples appropriate this visualization approach occur in abundance mathematical visualization, surface and volume problems, scientific applications such as general relativity. Our is using a controller to choose direction which walk manifold along geodesic path. The automatically generates orientation changes that produce maximal viewable region with each step walk. proposed...