A5087630822- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- Bone health and treatments
- Musculoskeletal pain and rehabilitation
- Plant Toxicity and Pharmacological Properties
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Osteoarthritis Treatment and Mechanisms
- Spinal Cord Injury Research
- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- interferon and immune responses
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Cytokine Signaling Pathways and Interactions
- Vector-borne infectious diseases
- NF-κB Signaling Pathways
- Heterotopic Ossification and Related Conditions
- Sulfur Compounds in Biology
- Selenium in Biological Systems
- Bone fractures and treatments
- Genomics, phytochemicals, and oxidative stress
- Cancer-related gene regulation
- Botulinum Toxin and Related Neurological Disorders
Shanghai Jiao Tong University
2020-2025
Shanghai Ninth People's Hospital
2020-2025
Regenerative Medicine Institute
2021
Fujian Medical University
2021
Sun Yat-sen Memorial Hospital
2021
Sun Yat-sen University
2021
Soochow University
2020
Wuxi Ninth People's Hospital
2020
Discography often destroys the hypoxic environment in intervertebral disc and accelerates degeneration (IVDD). Therefore, it fails to meet requirements for application clinical practice. This technology mainly increases reactive oxygen species (ROS) IVD. As so, is particularly critical develop strategies avoid this mechanism. Prussian blue nanoparticles (PBNPs) are found enhance development under magnetic resonance T1 have antioxidant enzyme activity. The key results of present study confirm...
Breast cancer metastases to bone poses a significant challenge for the administration of treatment strategies. The microenvironment, metastatic tumor cells, osteoclasts, and tumor-associated macrophages (TAMs) all play crucial synergistic roles in creating favorable environment proliferation, progression, survival tumor, which turn induces osteoclast-mediated destruction. In this study, we functionalized immunostimulatory cytosine-phosphate-guanosine (CpG)-loaded metal-organic framework...
Abstract Chemoresistance is the main obstacle in osteosarcoma (OS) treatment; however, underlying mechanism remains unclear. In this study, it discovered that DDRGK domain‐containing protein 1 (DDRGK1) plays a fundamental role chemoresistance induced OS. Bioinformatic and tissue analyses indicate higher expression of DDRGK1 correlates with advanced tumor stage poor clinical prognosis Quantitative proteomic suggest critical mitochondrial oxidative phosphorylation. knockout trigger...
RANKL and SCLEROSTIN antibodies have provided a strong effective choice for treating osteoporosis in the past years, which suggested novel molecular target identification therapeutic strategies development are important treatment of osteoporosis. The effect verapamil, drug previously used cardiovascular diseases, on diabetes was due to inhibition TXNIP expression, has also been reported as mice Whether verapamil-inhibited expression is related how it works level worthy be explored....
N-CDs inhibited osteoclast formation and overactivation<italic>via</italic>downregulating ROS.
Abstract Background Smart nanoscale drug delivery systems that target acidic tumor microenvironments (TME) could offer controlled release of drugs and modulate the hypoxic TME to enhance cancer therapy. The majority previously reported MnO 2 nanostructures are nanoparticles, nanosheets, or nanocomposites incorporated with other types which may not most effective method for loading therapeutic payloads. Previous studies have designed nanoshells achieve tumor-specific enhanced combination...
Rationale: Inflammatory macrophages and osteoclasts (OCs) play critical roles in joint inflammation, which feature the excessive production of reactive oxygen species (ROS), resulting synovial inflammation bone erosion.Scavenging ROS, especially by modulating mitochondrial metabolic activity, could be a desirable strategy for management inflammatory joints.This study aimed to develop mitochondria-targeted supramolecular drug delivery system with exogenous endogenous ROS-scavenging activities...
Hypophosphatasia (HPP) is a metabolic bone disease that manifests as developmental abnormalities in and dental tissues. HPP patients exhibit hypo-mineralization osteopenia due to the deficiency or malfunction of tissue non-specific alkaline phosphatase (TNAP), which catalyzes hydrolysis phosphate-containing molecules outside cells, promoting deposition hydroxyapatite extracellular matrix. Despite identification hundreds pathogenic TNAP mutations, detailed molecular pathology remains unclear....
Bone homeostasis between osteoclast bone resorption and osteoblastic formation is tightly regulated by a series of factors such as the receptor activator nuclear factor-κB ligand (RANKL). Denosumab that neutralizes RANKL effective widely applied in treatment postmenopausal osteoporosis. However, participated RANKL-related remodeling process primary secondary osteoporosis are less known. Revealing novel transcriptional regulatory mechanism great significance for After differential expression...
Low back pain is usually caused by intervertebral disc degeneration (IVDD), during which the involvement of oxidation system imbalance and inflammasome activation cannot be neglected. In this study, we aimed to validate expression level TXNIP in IVDD investigate function potential mechanism action verapamil. upregulated degenerate nucleus pulposus both humans rats, as well tert-butyl hydroperoxide (TBHP)-stimulated cells. Administration verapamil, a classic clinical drug, mitigated...
Rationale: Inflammatory osteolysis, characterized by abundant immune cell infiltration and osteoclast (OC) formation, is a common complication induced bacterial products and/or wear particles at the bone-prosthesis interface that severely reduces long-term stability after implantation.Molecular nanoclusters are ultrasmall with unique physicochemical biological properties have great potential as theranostic agents for treating inflammatory diseases.Methods: In this study, heterometallic PtAu2...
The pathogenesis of Intervertebral Disc Degeneration (IDD) is complex and multifactorial, with cellular senescence nucleus pulposus (NP) cells inflammation playing major roles in the progression IDD.The stimulator interferon genes (STING) axis a key mediator during infection, stress, tissue damage.Here, we present progressive increase STING senescent NP degradation disorder.The function normal can prevent IDD.However, dysfunction through autophagy causes accumulation high expression as well...
The progression of intervertebral disc degeneration (IDD) is multifactorial with the senescence nucleus pulposus (NP) cells and closely related to inflammation in NP cells. Dehydrocostus lactone (DHE) a natural sesquiterpene isolated from medicinal plants that has anti-inflammatory properties. Thus, DHE may have therapeutic effect on IDD. In this study, were used determine appropriate concentration vitro . role tumor necrosis factor-α (TNF-α)–induced activation inflammatory signaling...
Low back pain (LBP) induced by intervertebral disc degeneration (IDD) brings progressively painful status and impairs the normal daily living. Engeletin is a plant-derived medicine with anti-inflammation antioxidant functions. Therefore, we aim to confirm its protective effects against in vivo vitro.The cytotoxicity of engeletin was validated CCK-8 tests. Using TNF-α simulate inflammation vitro, expression inflammatory mediators MMP families were determined qPCR, Western blotting confocal...
With the clinical prevalence of drug-resistant pathogenic bacteria, developing non-antibiotic strategies to treat multi-drug-resistant bacterial infections is urgent yet challenging. Ferroptosis a non-apoptotic form regulated cell death that can overcome drug resistance. Emerging evidence shows potential triggering ferroptosis-like for anti-infection therapy, but direct delivery iron species inefficient and may cause detrimental effects. Herein, CuFeS2 nanozyme revealed as initiator...
Enhancer of zeste homolog 2 (EZH2) is a novel oncogene that can specifically trimethylate the histone H3 lysine 27 (H3K27me3) to transcriptionally inhibit expression downstream tumor-suppressing genes. As small molecular inhibitor EZH2, 3-Deazaneplanocin (DZNep) has been widely studied due role tumor suppression. With roles epigenetic regulation bone cells emerged in past decades, property and mechanism DZNep on enhancing osteogenesis had reported attracted great deal attention recently....
Intervertebral disc degeneration (IVDD) is a chronic musculoskeletal disorder causing lower back pain, imposing considerable burden on global health. Hyperglycemia resulting from diabetes mellitus induces advanced glycation end products (AGEs) accumulation in nucleus pulposus cells, leading to IVDD. Mitigating AGEs novel promising strategy for IVDD management. In our study, palladium nanoparticles (Pd NPs) preferentially colocalized within the endoplasmic reticulum and efficiently degraded...
Abstract Osteoarthritis (OA) inflammatory microenvironment triggered glucose metabolism and mitochondrial dysfunction in chondrocytes, leading to a shift of metabolic tendency between oxidative phosphorylation anaerobic glycolysis. Thioredoxin-interacting protein (Txnip) increased production reactive oxygen species (ROS), which exacerbates stress, inflammation further accelerates cartilage degeneration extracellular matrix (ECM) degradation. Txnip expression is also positively correlated...
The incidence of intervertebral disc degeneration (IDD) is increasing year by year, while the age onset IDD decreasing year. For individuals affected IDD, an alternative treatment to surgery required. thought be related nucleus pulposus (NP) cell senescence and inflammation. Therefore, inhibition NP inflammation may counteract IDD. We screened 20 small-molecule drugs compare their anti-inflammatory effects, finally selected homoplantaginin (HPG) as a regimen. HPG extract Salvia miltiorrhiza...
Breast cancer bone metastasis poses significant challenge for therapeutic strategies. Inside the metastatic environment, osteoclasts and tumor cells interact synergistically to promote progression. In this study, proprotein convertase furin is targeted due its critical roles in both cell invasion osteoclast function. Importantly, inhibitor specifically delivered by targeting superparamagnetic iron oxide (SPIO) nanoparticles. Our vitro vivo data demonstrate that system can effectively inhibit...