In the central nervous system, formation of fibrotic scar after injury inhibits axon regeneration and promotes repair. However, mechanism underlying regulation remains poorly understood. M2 macrophages regulate to heart, lung, kidney, system. it be clarified whether how cerebral ischemia injury. this study, we found that, in a rat model induced by middle artery occlusion/reperfusion, fibrosis macrophage infiltration were apparent ischemic core early stage (within 14 days injury). The number...

Aircraft cargo compartments are confined spaces during flight and require fire detection systems to alarm within seconds of the occurring, so these aviation need have a high degree real-time performance. This paper proposes an improved version MobileOne-YOLO object algorithm for detection. lightweight model is designed promptly efficiently detect occurrence fires. Firstly, MobileOne module integrated into backbone YOLOv5 model, which reduces algorithm’s parameters quantity. Secondly,...

Background/Aims: Neurite outgrowth and synaptogenesis are critical steps for functional recovery after stroke. Resveratrol promotes neurite synaptogenesis, but the underlying mechanism is not well understood, although Sonic hedgehog (Shh) signaling pathway may be involved. Given that resveratrol activates sirtuin (Sirt)1, present study examined whether this mediated by Shh signaling. Methods: Primary cortical neuron cultures were pretreated with drugs before oxygen-glucose...

To evaluate the prevalence of abnormal vitamin B12, folate, total homocysteine (tHcy), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) levels, to analyze relationship between these parameters and severity anxiety or depressive symptoms, explore possible factors associated with levels in adolescents symptoms.Adolescent (aged 12-18 years) outpatients symptoms were recruited. The patient health questionnaire-9 generalized disorder scale-7 used measure depression...

Background/Aims: There is interest in drugs and rehabilitation methods to enhance neurogenesis improve neurological function after brain injury or degeneration. Resveratrol may hippocampal atrophy chronic fatigue mice prenatally stressed rats. However, its effect mechanism of stroke less well understood. Sonic hedgehog (Shh) signaling crucial for the embryonic adult brain, but relatively little known about role Shh resveratrol-enhanced stroke. Methods: Neural stem cells (NSCs) before...

This study aimed to identify and quantify the association investigate whether serum vitamin B12 alone or combined with folate plasma total homocysteine (tHcy) levels could be used predict risk of acute ischemic stroke.

Journal Article Nanoformulation of d-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) diblock copolymer for breast cancer therapy Get access Laiqiang Huang, Huang School Life Sciences, Tsinghua University, Beijing 100084, P.R. China. Fax: +86 755 26036736; Tel: 26036736The Shenzhen Key Lab Gene and Antibody Therapy Division Graduate at Shenzhen, Guangdong 518055, China Search other works by this author on: Oxford Academic Google Scholar Hongbo Chen, Chen...

Abstract Cervical cancer remains a major problem in women's health worldwide. In this research, novel biodegradable d-α-tocopheryl polyethylene glycol 1000 succinate- b -poly(ε-caprolactone- ran- glycolide) (TPGS- -(PCL- ran -PGA)) nanoparticle (NP) was developed as co-delivery system of docetaxel and endostatin for the synergistic treatment cervical cancer. Docetaxel-loaded TPGS- -PGA) NPs were prepared further modified by polyethyleneimine coating plasmid pShuttle2-endostatin. All...

Heterotrimeric G-proteins, including Galpha(i2), have been implicated in modulating glucose disposal and insulin signaling. This cross-talk between G-protein-coupled tyrosine kinase-coupled signaling pathways is a focal point for the study of integration cell Herein we role Galpha(i2) transport, focusing upon linkages to Utilizing mice harboring transgene that directs expression constitutively activated, GTPase-deficient mutant (Q205L) adipose tissue, skeletal muscle, liver, demonstrate...

Background and purpose: Clinically, the ability to identify individuals at risk of ischemic stroke remains limited. This study aimed develop a nomogram model for predicting acute stroke. Methods: In this study, we conducted retrospective analysis on patients who visited Department Neurology, collecting important information including clinical records, demographic characteristics, complete hematological tests. Participants were randomly divided into training internal validation sets in 7:3...

Ischemic stroke is a leading cause of mortality and disability globally, necessitating accurate prediction intra-hospital (IHM) for improved patient care. This study aimed to develop practical nomogram personalized IHM risk in ischemic patients.

During flight, aircraft cargo compartments are in a confined state. If fire occurs, it will seriously affect flight safety. Therefore, detection systems must issue alarms within seconds of breaking out, necessitating high real-time performance for aviation systems. In addressing the target detection, YOLO series models demonstrate superior striking balance between computational efficiency and recognition accuracy when compared with alternative models. Consequently, this paper opts to...

ObjectiveThis study aimed to determine the characteristics and risk factors of adult new-onset seizure patients with tuberculous meningitis (TBM) during long-term follow-up.MethodsPatients TBM who were seen between June 2012 January 2018 retrospectively reviewed categorized into two groups based on presence or absence seizures. Seizure characteristics, functional outcomes assessed.ResultsA total 223 enrolled, including 20.6% (46/223) In all, 39.1% (18/46) seizures 14.1% (25/177) without died...

Insulin stimulates a rapid phosphorylation and sequestration of the β 2 -adrenergic receptor. Analysis signaling downstream insulin receptor with enzyme inhibitors revealed roles for both phosphatidylinositol 3-kinase pp60Src. Inhibition Src PP2, like inhibition LY294002 [2-(4-morpholynyl)-8-phenyl-4H-1-benzopyran-4-one], blocked activation as well insulin-stimulated Depletion antisense morpholinos also suppressed sequestration. is shown to be phosphorylated/activated in response human...

Studies have found that BH3 interacting domain death agonist (BID) is closely related to the occurrence and development of many kinds tumors. However, little attention has been paid situation BID in clear cell renal carcinoma (ccRCC). So, our aim was explore effect ccRCC.

As an important research direction of the energy system, integrated system a park plays role in field optimization and sustainable economic operation. In this study, low-carbon optimal operation model industrial is proposed, considering controllable flexible load response. First, typical structure each subsystem are introduced; then, under premise that electrical thermal loads can be used for adjustment utilization, complete dispatch scheme constructed according to consumption...

Farmer's credit is significant to growing the farmer's revenue and progression of rural economy. Several scholars have focused on impact social capital farmers' availability, but research deduction still not combined. In addition, behavior an important element that researchers pay attention to. However, study mainly focuses effects farmer households its large positive effect, a scientific approach for measuring households' was presented. The strategy attempted develop empirical model loan...