A5044879882- Cancer-related molecular mechanisms research
- Aortic aneurysm repair treatments
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Biomarkers in Disease Mechanisms
- Parathyroid Disorders and Treatments
- Connective tissue disorders research
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Diabetes Treatment and Management
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Diet and metabolism studies
- Protease and Inhibitor Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Lipids, and Metabolism
- Bone and Joint Diseases
- Cell Adhesion Molecules Research
Zhujiang Hospital
2021-2025
Southern Medical University
2021-2025
Guangdong Provincial Center for Disease Control and Prevention
2021-2022
Key Laboratory of Guangdong Province
2021-2022
Abstract Vascular calcification is a common pathologic condition in patients with chronic kidney disease (CKD) and aging individuals. It has been established that vascular gene‐regulated biological process resembling osteogenesis involving osteogenic differentiation. However, there no efficient treatment available for so far. The natural polyamine spermidine demonstrated to increase life span protect against cardiovascular disease. unclear whether supplementation inhibits CKD. Alizarin red...
Vascular calcification (VC) is prevalent in pathological processes such as diabetes, chronic kidney disease (CKD), and atherosclerosis, but effective therapies are still lacking by far. Canagliflozin (CANA), a sodium-glucose cotransporter 2 inhibitor, has been approved for the treatment of type diabetes mellitus exhibits beneficial effects against cardiovascular disease. However, effect CANA on VC remains unknown. In this study, we hypothesize that protects VC.Micro-computed tomography...
Abstract Vascular calcification is an actively regulated process resembling bone formation and contributes to the cardiovascular morbidity mortality of chronic kidney disease (CKD). However, effective therapy for vascular still lacking. The ketone body β‐hydroxybutyrate (BHB) has been demonstrated have health‐promoting effects including anti‐inflammation protective effects. whether BHB protects against in CKD remains unclear. In this study, Alizarin Red staining calcium content assay showed...
Abstract Vascular calcification is an actively regulated biological process resembling bone formation, and osteogenic differentiation of vascular smooth muscle cells (VSMCs) plays a crucial role in this process. 1‐Palmitoyl‐2‐(5′‐oxo‐valeroyl)‐sn‐glycero‐3‐phosphocholine (POVPC), oxidized phospholipid, found atherosclerotic plaques has been shown to induce oxidative stress. However, the effects POVPC on VSMCs have yet be studied. In present study, we investigated using vitro ex vivo models....
Abstract Vascular calcification is an important risk factor related to all‐cause mortality of cardiovascular events in patients with chronic kidney disease (CKD). extracellular matrix (ECM) proteins have been demonstrated regulate vascular calcification. ECM protein thrombospondin 1 (THBS1/TSP‐1) plays a critical role the regulation diseases. However, whether THBS1 involved CKD remains unclear. In this study, RNA sequencing datasets from Gene Expression Omnibus (GEO) database GSE146638...
ABSTRACT Vascular calcification is an independent predictor of cardiovascular mortality in patients with chronic kidney disease (CKD), yet no approved treatment exists. The cGAS‐STING signaling participates various diseases. Notably, DNA damage, important regulator vascular calcification, activates the signaling. However, it remains poorly understood whether STING regulates under CKD conditions. In current study, we showed that expression was elevated during calcification. knockdown or...
ABSTRACT Vascular calcification, an age‐associated disorder, is a highly regulated biological process similar to bone formation. Growth differentiation factor 11 (GDF11), secreted member of the transforming growth beta (TGF‐β) superfamily, has been shown act as anti‐aging in brain, heart, skin, and skeletal muscle. Nevertheless, whether GDF11 affects vascular calcification underlying mechanisms remain unclear. In present study, beta‐glycerophosphate calcium chloride‐induced smooth muscle...