A5027783471- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Diabetes Management and Research
- Pancreatitis Pathology and Treatment
- IgG4-Related and Inflammatory Diseases
- RNA Interference and Gene Delivery
- Gut microbiota and health
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Congenital Ear and Nasal Anomalies
- Nasal Surgery and Airway Studies
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Cellular transport and secretion
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- Vitamin D Research Studies
- Olfactory and Sensory Function Studies
- Biotin and Related Studies
National Applied Research Laboratories
2022-2024
CHA University
2011-2012
CHA Bundang Medical Center
2011-2012
National Defense Medical Center
2010-2011
Stanford University
2009-2010
Institute of Biological Chemistry, Academia Sinica
2006
Institute of Life Sciences
2004
Decoy receptor 3 (DCR3) halts both Fas ligand– and LIGHT-induced cell deaths, which are required for pancreatic β damage in autoimmune diabetes. To directly investigate the therapeutic potential of DCR3 preventing this disease, we generated transgenic nonobese diabetic mice, overexpressed cells. Transgenic protected mice from cyclophosphamide-induced diabetes a dose-dependent manner significantly reduced severity insulitis. Local expression transgene did not alter diabetogenic properties...
Mutations in the PB1 subunit of RNA-dependent RNA polymerase (RdRp) influenza A virus can affect replication fidelity. Before A/H1N1 pandemic 2009, most human viruses contained avian-associated residue, serine, at position 216 PB1. However, near onset 2009 pandemic, began to acquire mammalian-associated glycine, PB1-216, and PB1-216G became predominant thereafter.Using entropy-based analysis algorithm, we have previously identified several host-specific amino-acid signatures that separated...
We characterized a family diagnosed with immunodeficiency disease presenting low immunoglobulin levels and skin dyskeratosis. Exome sequencing revealed compound heterozygous missense variants in SLC5A6, the gene encoding cellular sodium-dependent multivitamin transporter (SMVT) responsible for transporting vitamins, including biotin (vitamin B7). showed that deficiency was caused by SLC5A6 resulting defective B cell differentiation antibody deficiency. Altered metabolic profiles, aberrant...
Atherosclerosis is the main cause of cardiac and peripheral vessel infarction in developed countries. Recent studies have established that gut microbiota their metabolites play important roles development progression cardiovascular disease; however, underlying mechanisms remain unclear. The present study aimed to investigate endothelium plaque lesion formation ApoE-deficient rats fed a normal chow diet under germ-free (GF) specific-pathogen-free (SPF) conditions at various time points. There...
The novel allele B*40:179 showed one nucleotide difference with B*40:01:01 in exon 4.
The novel allele A*02:328 showed one nucleotide difference with A*02:06:01 in exon 3 resulting an amino acid change at codon 120 from Gly to Arg.
The novel alleles DRB1 *12:03:03 and *13:143 differ from *12:03:02 *13:02:01 by one nucleotide in exon 2, respectively.
Specific anti-CD3 treatment is deemed to be a promising therapy for allograft rejection and type 1 diabetes (T1D). Fc receptor (FcR) reduced-binding antibodies, by avoiding adverse effects of FcR interaction, have good therapeutic potential. We generated trivalent anti-mouse-CD3 Collabody, h145CSA, using triplex-forming collagen-like peptide (Gly-Pro-Pro) 10 drive the trimerization Fab fragments. Exposure but not its bivalent counterparts 145-2C11 h145chIgGAA (FcR format), upregulates FasL...
Nasal obstruction exerts considerable physiological effects on the respiratory system and craniofacial morphology during developmental stage. This study used MMP-3-LUC transgenic rats for in vivo tracking of long-term expression rat nasal region after unilateral obstruction. Skeletal changes craniofacial, nasal, sinus regions were measured through micro-computed tomography examination analysis with 3D image processing calculation. Matrix metalloproteinase-3 olfactory marker protein also...
Abstract Background Therapeutic interventions for diabetes are most effective when administered in the newly onset phase, yet determining exact moment can be elusive practice. Spontaneous autoimmune among NOD mice appears randomly between 12 and 32 weeks of age with an incidence range from 60 to 90%. Furthermore, disease often progresses rapidly severe within days, resulting a very short window that poses significant challenge early diagnosis. Conventionally, extensive blood glucose (BG)...
Abstract Determining the onset of diabetes based on blood glucose (BG) levels can be challenging in mouse models, as thresholds vary from 200 to 400 mg/dl one or two consecutive tests. Urine (UG) detected non-invasively another criterion diabetic condition, but it is considered a lagging indicator due physiological downstream BG. In this study, we demonstrate that period practically unnoticeable spontaneously model non-obese (NOD) mice which develop autoimmune randomly 12 32 weeks age. After...